Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Shanna, Hamilton"'
Autor:
Kelsey M. Pinckard, Elisa Félix-Soriano, Shanna Hamilton, Radmila Terentyeva, Lisa A. Baer, Katherine R. Wright, Drew Nassal, Joao Victor Esteves, Eaman Abay, Vikram K. Shettigar, Mark T. Ziolo, Thomas J. Hund, Loren E. Wold, Dmitry Terentyev, Kristin I. Stanford
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101914- (2024)
Objective: The intrauterine environment during pregnancy is a critical factor in the development of obesity, diabetes, and cardiovascular disease in offspring. Maternal exercise prevents the detrimental effects of a maternal high fat diet on the meta
Externí odkaz:
https://doaj.org/article/43233158c48a4f618c81e1532dc8152a
Autor:
Shanna Hamilton, Dmitry Terentyev
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The sarcoplasmic reticulum (SR) plays the key role in cardiac function as the major source of Ca2+ that activates cardiomyocyte contractile machinery. Disturbances in finely-tuned SR Ca2+ release by SR Ca2+ channel ryanodine receptor (RyR2) and SR Ca
Externí odkaz:
https://doaj.org/article/7541720cf8224e95906f3131f7fdd947
Autor:
Richard T. Clements, Radmila Terentyeva, Shanna Hamilton, Paul M. L. Janssen, Karim Roder, Benjamin Y. Martin, Fruzsina Perger, Timothy Schneider, Zuzana Nichtova, Anindhya S. Das, Roland Veress, Beth S. Lee, Do-Gyoon Kim, Gideon Koren, Matthew S. Stratton, Gyorgy Csordas, Federica Accornero, Andriy E. Belevych, Sandor Gyorke, Dmitry Terentyev
Publikováno v:
Basic Research in Cardiology. 118
Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca2+ release is essential to boost energy production in ventricular cardiomyocytes (VCMs) and match increased metabolic demand. Mitochondria from female hearts exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbc16c7193cf2b8cedadcf67efa7dafc
https://doi.org/10.1007/s00395-023-00988-1
https://doi.org/10.1007/s00395-023-00988-1
Autor:
Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T. Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca2+ uptake, an important regulator of cellular ATP homeostas
Externí odkaz:
https://doaj.org/article/afd9fd2a470d40ac8bbdb50a6b5dfb09
Autor:
Shanna Hamilton, Dmitry Terentyev
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
A rapid growth in the incidence of diabetes and obesity has transpired to a major heath issue and economic burden in the postindustrial world, with more than 29 million patients affected in the United States alone. Cardiovascular defects have been es
Externí odkaz:
https://doaj.org/article/95584b7544084b3dbc5167bd1b6e07a7
Autor:
Benjamin Martin, Matthew W. Gorr, Richard T. Clements, Fruzsina Perger, Sandor Gyorke, Benjamin Hernandez Orengo, Dmitry Terentyev, Andriy E. Belevych, Radmila Terentyeva, Shanna Hamilton
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 321:H615-H632
Defective intracellular Ca2+ homeostasis and aberrant mitochondrial function are common features in cardiac disease. Here, we directly compared potential benefits of mito-ROS scavenging and restoration of mito-Ca2+ uptake by overexpressing MCU in ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb9530054661e309d66567bb924a2cb
https://doi.org/10.1152/ajpheart.00126.2021
https://doi.org/10.1152/ajpheart.00126.2021
Autor:
Devasena Ponnalagu, Shanna Hamilton, Shridhar Sanghvi, Diego Antelo, Neill Schwieterman, Inderjot Hansra, Xianyao Xu, Erhe Gao, John C. Edwards, Shyam S. Bansal, Loren E. Wold, Dmitry Terentyev, Paul M. L. Janssen, Thomas J. Hund, Mahmood Khan, Andrew R. Kohut, Walter J. Koch, Harpreet Singh
Publikováno v:
Science Advances. 8
Mitochondrial-associated membranes (MAMs) are known to modulate organellar and cellular functions and can subsequently affect pathophysiology including myocardial ischemia-reperfusion (IR) injury. Thus, identifying molecular targets in MAMs that regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33578b0d632c84af1f3697f03be2210
https://doi.org/10.1126/sciadv.abo1244
https://doi.org/10.1126/sciadv.abo1244
Autor:
Shanna Hamilton, Radmila Terentyeva, Roland Veress, Fruzsina Perger, Zuzana Nichtova, Benjamin Martin, Sandor Gyorke, Andriy Belevych, Gyorgy Csordas, Dmitry Terentyev
Publikováno v:
Circulation Research. 131
Intracellular Ca 2+ cycling in ventricular myocytes (VMs) is tightly linked to mitochondrial metabolic output, and disturbances in this coupling contribute to cardiac arrhythmias. We recently demonstrated in the heritable arrhythmia syndrome catechol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e082521adb52c46df41c68c16318a4e4
https://doi.org/10.1161/res.131.suppl_1.p1083
https://doi.org/10.1161/res.131.suppl_1.p1083
Autor:
Richard T. Clements, Shanna Hamilton, Dmitry Terentyev, Andriy E. Belevych, Radmila Terentyeva
Publikováno v:
J Mol Cell Cardiol
Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88bc40c855ee063c21fe5ce2214f4d1
https://doi.org/10.1016/j.yjmcc.2021.04.002
https://doi.org/10.1016/j.yjmcc.2021.04.002
Publikováno v:
Pflugers Archiv
Sudden cardiac death due to malignant ventricular arrhythmias remains the major cause of mortality in the postindustrial world. Defective intracellular Ca2+ homeostasis has been well established as a key contributing factor to the enhanced propensity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3394a3c6fda937c05a1dc3625a9d1051
https://doi.org/10.1007/s00424-020-02505-y
https://doi.org/10.1007/s00424-020-02505-y