Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.

Autor: Baran N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lodi A; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Dhungana Y; St. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Herbrich S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Collins M; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Sweeney S; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Pandey R; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Skwarska A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Patel S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tremblay M; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Kuruvilla VM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cavazos A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kaplan M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Warmoes MO; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Veiga DT; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Furudate K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan., Rojas-Sutterin S; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Haman A; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Gareau Y; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Marinier A; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Ma H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Harutyunyan K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Daher M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Garcia LM; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Al-Atrash G; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Piya S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ruvolo V; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yang W; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Shanmugavelandy SS; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; TRACTION Platform, Therapeutics Discovery Division, University of Texas M. D. Anderson Cancer Center, Houston, USA., Gay J; TRACTION Platform, Therapeutics Discovery Division, University of Texas M. D. Anderson Cancer Center, Houston, USA., Du D; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yang JJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Hoff FW; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kaminski M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Tomczak K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Eric Davis R; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Herranz D; Rutgers Robert Wood Johnson Medical School, Cancer Institute of New Jersey, New Brunswick, NJ, USA., Ferrando A; Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY, USA., Jabbour EJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Emilia Di Francesco M; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Teachey DT; Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA., Horton TM; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA., Kornblau S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rezvani K; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sauvageau G; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Gagea M; Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Takahashi K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Marszalek JR; TRACTION Platform, Therapeutics Discovery Division, University of Texas M. D. Anderson Cancer Center, Houston, USA., Lorenzi PL; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Tiziani S; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Hoang T; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada.; Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada., Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. mkonople@mdanderson.org.

Publikováno v: Nature communications [Nat Commun] 2022 May 19; Vol. 13 (1), pp. 2801. Date of Electronic Publication: 2022 May 19.

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH.

Autor: Zanieri F; Department of Experimental and Clinical Medicine and Center of Excellence 'DENOthe', University of Florence, 50134 Florence, Italy., Levi A; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK., Montefusco D; Virginia Commonwealth University, Richmond, VA 23219, USA., Longato L; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK., De Chiara F; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK., Frenguelli L; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK., Omenetti S; Department of Experimental and Clinical Medicine and Center of Excellence 'DENOthe', University of Florence, 50134 Florence, Italy., Andreola F; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK., Luong TV; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK.; Department of Cellular Pathology, Royal Free Hospital, London NW3 2PF, UK., Massey V; Division of Hepatology and Gastroenterology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Caballeria J; Hepatology, Hospital Clínic, IDIBAPS, CIBERehd, 08036 Barcelona, Spain., Fondevila C; Liver Transplant Unit, Department of Surgery, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain., Shanmugavelandy SS; Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA., Fox T; Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA., Mazza G; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK., Argemi J; Department of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA., Bataller R; Division of Hepatology and Gastroenterology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA., Cowart LA; Virginia Commonwealth University, Richmond, VA 23219, USA.; Hunter Holmes McGuire VA Medical Center, Richmond, VA 23219, USA., Kester M; Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA.; Department of Pharmacology, University of Virginia School of Medicine, P.O. Box 800735, Charlottesville, VA 22908, USA., Pinzani M; Department of Experimental and Clinical Medicine and Center of Excellence 'DENOthe', University of Florence, 50134 Florence, Italy.; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK.; Sheila Sherlock Liver Centre, Royal Free London NHS Foundation Trust, London NW3 2PF, UK., Rombouts K; Department of Experimental and Clinical Medicine and Center of Excellence 'DENOthe', University of Florence, 50134 Florence, Italy.; Institute for Liver & Digestive Health, Royal Free, University College London UCL, London NW3 2PF, UK.

Publikováno v: Cells [Cells] 2020 May 16; Vol. 9 (5). Date of Electronic Publication: 2020 May 16.

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia.

Autor: Barth BM; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH.; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Wang W; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Toran PT; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Fox TE; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA., Annageldiyev C; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Ondrasik RM; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Keasey NR; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Brown TJ; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Devine VG; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Sullivan EC; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Cote AL; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Papakotsi V; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Tan SF; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Shanmugavelandy SS; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA., Deering TG; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA., Needle DB; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Stern ST; Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick National Laboratory for Cancer Research, Frederick, MD., Zhu J; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA., Liao J; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA., Viny AD; Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Feith DJ; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Levine RL; Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Wang HG; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Pediatric Molecular Oncology Program, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA; and., Loughran TP Jr; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Sharma A; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA., Kester M; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA.; nanoSTAR Institute, University of Virginia, Charlottesville, VA., Claxton DF; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.

Publikováno v: Blood advances [Blood Adv] 2019 Sep 10; Vol. 3 (17), pp. 2598-2603.

Engraftment of Human Primary Acute Myeloid Leukemia Defined by Integrated Genetic Profiling in NOD/SCID/IL2rγnull Mice for Preclinical Ceramide-Based Therapeutic Evaluation.

Autor: Barth BM; Department of Medicine, Penn State College of Medicine, Hershey, USA; Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, USA., Keasey NR; Department of Medicine, Penn State College of Medicine, Hershey, USA; Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, USA., Wang X; Department of Medicine, Penn State College of Medicine, Hershey, USA; Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, USA., Shanmugavelandy SS; Department of Pharmacology, Penn State College of Medicine, Hershey, USA., Rampal R; Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, USA; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, USA., Hricik T; Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, USA; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, USA., Cabot MC; Department of Biochemistry and Molecular Biology, East Carolina University, Greenville, USA., Kester M; University of Virginia Cancer Center, Charlottesville, USA., Wang HG; Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, USA; Department of Pharmacology, Penn State College of Medicine, Hershey, USA; Department of Pediatrics, Penn State College of Medicine, Hershey, USA., Shultz LD; The Jackson Laboratory, Bar Harbor, USA., Tallman MS; Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, USA., Levine RL; Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, USA; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, USA., Loughran TP Jr; University of Virginia Cancer Center, Charlottesville, USA., Claxton DF; Department of Medicine, Penn State College of Medicine, Hershey, USA; Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, USA.

Publikováno v: Journal of leukemia (Los Angeles, Calif.) [J Leuk (Los Angel)] 2014 Sep; Vol. 2 (3). Date of Electronic Publication: 2014 Jul 25.

Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models.

Autor: Adiseshaiah PP; Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States., Clogston JD, McLeland CB, Rodriguez J, Potter TM, Neun BW, Skoczen SL, Shanmugavelandy SS, Kester M, Stern ST, McNeil SE

Publikováno v: Cancer letters [Cancer Lett] 2013 Sep 01; Vol. 337 (2), pp. 254-65. Date of Electronic Publication: 2013 May 07.