Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Shanmugam Nagarajan"'
Autor:
Crescentia Cho, Uma M. Nagarajan, Ian Huntress, Hayden N. Brochu, Erin Harrell, J. Ashley Ezzell, Shanmugam Nagarajan, Clare E. Gyorke, Xinxia Peng
Publikováno v:
J Infect Dis
Chlamydia trachomatis-genital infection in women can be modeled in mice using Chlamydia muridarum. Using this model, it has been shown that the cytokines tumor necrosis factor (TNF)α and interleukin (IL)-1α lead to irreversible tissue damage in the
Akademický článek
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Autor:
Branimir Popovic, Pamelia E. Fraungruber, Uma M. Nagarajan, Ramona L. Burris, Catherine L. Haggerty, James D. Sikes, Rajneesh Jha, Shanmugam Nagarajan, Leah Hennings
Publikováno v:
Atherosclerosis
Background and aims Atherosclerosis is a chronic inflammatory disease, and recent studies have shown that infection at remote sites can contribute to the progression of atherosclerosis in hyperlipidemic mouse models. In this report, we tested the hyp
Akademický článek
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Autor:
Branimir Popovic, Sarah C. Vick, Pamelia E. Fraungruber, Ramona L. Burris, Shanmugam Nagarajan
Publikováno v:
Atherosclerosis
BACKGROUND AND AIMS. Maternal hypercholesterolemia has been implicated in the earlier onset of atherosclerotic lesions in neonatal offspring. In this study, we investigated whether maternal exposure to soy protein isolate (SPI) diet attenuated the pr
Autor:
Alexander Kikuchi, Shanmugam Nagarajan, Satdarshan P.S. Monga, Nick Loizos, Tirthadipa Pradhan-Sundd, Sucha Singh
Publikováno v:
The American Journal of Pathology. 187:2273-2287
Platelet-derived growth factor receptor α (PDGFRα), a tyrosine kinase receptor, is up-regulated in hepatic stellate cells (HSCs) during chronic liver injury. HSCs mediate hepatic fibrosis through their activation from a quiescent state partially in
Autor:
Satdarshan P.S. Monga, Akshata Moghe, Pamela K. Cornuet, Kari Nejak-Bowen, Shanmugam Nagarajan, Morgan Preziosi
Publikováno v:
Gene Expression. 17:219-235
An important role for β-catenin in regulating p65 (a subunit of NF-κB) during acute liver injury has recently been elucidated through use of conditional β-catenin knockout mice, which show protection from apoptosis through increased activation of
Autor:
Patrick J. Pagano, Bhupesh Singla, Huiping Lin, Simon C. Watkins, Eric E. Kelley, Pushpankur Ghoshal, Douglas M. Feck, Nadiezhda Cantu-Medellin, Shanmugam Nagarajan, Lukasz Mateuszuk, Daniel N. Meijles, Gabor Csanyi, Jeffrey S. Isenberg, Imad Al Ghouleh
Publikováno v:
Antioxidants & Redox Signaling. 26:886-901
AIMS: Macropinocytosis has been implicated in cardiovascular and other disorders, yet physiological factors that initiate fluid-phase internalization and the signaling mechanisms involved remain poorly identified. The present study was designed to ex
Autor:
Yoshitaka Miyagawa, Hideo Baba, Kyle Sylakowski, Jing Yang, Satdarshan P.S. Monga, Mladen I. Yovchev, Kari Nejak-Bowen, Michael D. Thompson, Hirohisa Okabe, Shanmugam Nagarajan, Maria Chikina, Michael Oertel
Publikováno v:
Hepatology. 64:1652-1666
Hepatic repair is directed chiefly by the proliferation of resident mature epithelial cells. Furthermore, if predominant injury is to cholangiocytes, the hepatocytes can transdifferentiate to cholangiocytes to assist in the repair and vice versa, as
Autor:
Satdarshan P.S. Monga, An Jiang, Tirthadipa Pradhan-Sundd, Sucha Singh, Minakshi Poddar, Morgan Preziosi, Shanmugam Nagarajan, Steven G. England, Aaron Bell, Hirohisa Okabe, Branimir Popovic
Publikováno v:
The American journal of pathology. 189(3)
Exposure of mice to a diet containing 3,5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) induces porphyrin accumulation, cholestasis, immune response, and hepatobiliary damage mimicking hepatic porphyria and sclerosing cholangitis. Although β-catenin