Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shanli Tsui"'
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162071 (2016)
BACKGROUND:The purpose of the study is to elicit the epigenetic mechanism involving CCCTC binding factor (CTCF)-mediated chromatin remodeling that regulates PAX6 gene interaction with differentiation-associated genes to control corneal epithelial dif
Externí odkaz:
https://doaj.org/article/e6580cc8263c422aa37090229430defa
Autor:
Neil Hoa, Shanli Tsui, Nikoo F Afifiyan, Amiya Sinha Hikim, Bin Li, Raymond S Douglas, Terry J Smith
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34173 (2012)
Insulin-like growth factor-1 receptor (IGF-1R) comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ. IGF-1R is over-expressed by orbital fibroblasts in the autoi
Externí odkaz:
https://doaj.org/article/051ac3add0bf4b06b94429bd217a6900
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162071 (2016)
PLoS ONE
PLoS ONE
Background The purpose of the study is to elicit the epigenetic mechanism involving CCCTC binding factor (CTCF)-mediated chromatin remodeling that regulates PAX6 gene interaction with differentiation-associated genes to control corneal epithelial dif
Publikováno v:
Journal of Biological Chemistry. 286:24487-24499
UDP-glucose dehydrogenase (UGDH) catalyzes the formation of UDP-glucuronate. Glucuronate represents an integral component of the glycosaminoglycan, hyaluronan, which accumulates in orbital Graves disease. Here we report that orbital fibroblasts expre
Autor:
Neil Hoa, Shanli Tsui, Nikoo F. Afifiyan, Raymond S. Douglas, Catherine J. Hwang, Vibha Naik, Terry J. Smith, Andrew G. Gianoukakis, Amiya P. Sinha Hikim
Publikováno v:
The Journal of Immunology. 181:4397-4405
Thyroid-stimulating hormone receptor (TSHR) plays a central role in regulating thyroid function and is targeted by IgGs in Graves’ disease (GD-IgG). Whether TSHR is involved in the pathogenesis of thyroid-associated ophthalmopathy (TAO), the orbita
Autor:
Raymond S. Douglas, Beiling Chen, Terry J. Smith, Shanli Tsui, William E. Boeglin, Alan R. Brash
Publikováno v:
Journal of Biological Chemistry. 281:18296-18306
Orbital fibroblasts orchestrate tissue remodeling in Graves disease, at least in part, because they exhibit exaggerated responses to proinflammatory cytokines. A hallmark of late stage orbital disease is vision-threatening fibrosis, the molecular bas
Publikováno v:
Biology of Reproduction. 62:1655-1660
The DAZ (Deleted in AZoospermia) gene family was isolated from a region of the human Y chromosome long arm that is deleted in about 10% of infertile men with idiopathic azoospermia. DAZ and an autosomal DAZ-like gene, DAZL1, are expressed in germ cel
Publikováno v:
Genomics. 65:266-273
The human DAZ (deleted in azoospermia) gene family on the Y chromosome and an autosomal DAZ-like gene, DAZL1, encode RNA-binding proteins that are expressed exclusively in germ cells. Their role in spermatogenesis is supported by their homology with
Publikováno v:
Cell proliferation. 47(1)
Objectives Pancreatic islet β-cell survival is paramount for regulation of insulin activity and for maintaining glucose homeostasis. Recently, Pax6 has been shown to be essential for many vital functions in β-cells, although many molecular mechanis
Pancreatic islet α-cell development and glucagon production are mainly regulated by Pax6 in the homeobox gene families. However, the molecular mechanism fine-tuning the regulation of these events in α-cell still remains unclear. In ocular cells, Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4e69d55a9b4d5d4437ce05f0ede3d8
https://europepmc.org/articles/PMC3875169/
https://europepmc.org/articles/PMC3875169/