Výsledky vyhledávání - "Shankley, N. P."

Akademický článek

Interpretation of Agonist Affinity Estimations: The Question of Distributed Receptor States

Publikováno v: Proceedings of the Royal Society of London. Series B, Biological Sciences, 1990 Jun . 240(1299), 503-518.

Externí odkaz: https://www.jstor.org/stable/49476

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Akademický článek

Correlation of apparent affinity values from H3-receptor binding assays with apparent affinity (pKapp) and intrinsic activity (α) from functional bioassays.

Autor: Harper, E. A.¹ elaine.harper@kcl.ac.uk, Shankley, N. P.¹, Black, J. W.¹

Publikováno v: British Journal of Pharmacology. May2007, Vol. 151 Issue 1, p128-143. 16p. 2 Diagrams, 5 Charts.

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Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction

Autor: Barrett, T D, Yan, W, Freedman, J M, Lagaud, G J, Breitenbucher, J G, Shankley, N P

Cholecystokinin (CCK) stimulates the release of amylase and lipase from the normal pancreas. However, it is not clear to what extent this occurs in the early stages of pancreatitis induced by biliary tract obstruction in the rat and whether CCK initi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f45d66013b4f11eb9116e6f8c59f471
https://europepmc.org/articles/PMC2438255/

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Correlation of apparent affinity values from H3-receptor binding assays with apparent affinity (pKapp) and intrinsic activity (α) from functional bioassays

Autor: Harper, E A, Shankley, N P, Black, J W

Agonist apparent affinities (pK(I)') in histamine H(3)-receptor binding assays were higher than expected from apparent affinity values (pK(app)) estimated in bioassay. Here, we investigate whether the degree of pK(I)' overestimation is related to ago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9e153db7b05afa131c06d41cc1711d2
https://europepmc.org/articles/PMC2012978/

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Pharmacological comparison of the alternatively spliced short and long CCK2 receptors

Autor: Morton, M F, Harper, E A, Tavares, I A, Shankley, N P

(1) The alternatively spliced, short and long cholecystokinin receptors (CCK2S and CCK2L) were expressed in NIH3T3 cells, and compared using radioligand-binding assays with identical buffer and incubation conditions. (2) As judged by a saturation ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c7b2c3f878a5ef3bee63f8fef801df6
https://europepmc.org/articles/PMC1574017/

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Pharmacological evidence for putative CCK1 receptor heterogeneity in human colon smooth muscle

Autor: Morton, M F, Harper, E A, Tavares, I A, Shankley, N P

1. The pharmacology of the cholecystokinin CCK(1) receptors endogenously expressed in human gallbladder and human ascending colon smooth muscle tissue was compared using radioligand binding assays. 2. Saturation analysis of the interaction between th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d19d9961b9621e01f7ca8234fd641c3
https://europepmc.org/articles/PMC1573423/

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Characterization of the binding of [3H]-clobenpropit to histamine H3-receptors in guinea-pig cerebral cortex membranes

Autor: Harper, E A, Shankley, N P, Black, J W

1 We have investigated the binding of a novel histamine H3-receptor antagonist radioligand, [3H]- clobenpropit ([3H]-VUF9153), to guinea-pig cerebral cortex membranes. 2 Saturation isotherms for [3H]-clobenpropit appeared biphasic. Scatchard plots we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2f7181016e294685e162bde726703a5
https://europepmc.org/articles/PMC1571704/

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International union of pharmacology. XIII. Classification of histamine receptors

Autor: Stephen Hill, Ganellin, C. R., Timmerman, H., Schwartz, J. C., Shankley, N. P., Young, J. M., Schunack, W., Levi, R., Haas, H. L.

Publikováno v: Pharmacological Reviews, 49, 253-278. American Society for Pharmacology and Experimental Therapeutics
Hill, S J, Ganellin, C R, Timmerman, H, Schwartz, J C, Shankley, N P, Young, J M, Schunack, W, Levi, R & Haas, H L 1997, ' International union of pharmacology. XIII. Classification of histamine receptors. ', Pharmacological Reviews, vol. 49, pp. 253-278 .
Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b7ffb3b5bb09065d4b78912e20af145c
https://research.vu.nl/en/publications/cf6fd5de-6c6f-4228-9aa1-1b353ac991c4

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