Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Shankari, Nair"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1467 (2024)
Background: Since the discovery that Histone deacetylase inhibitors (HDCAi) could enhance radiation response, a number of HDACi, mainly pan-HDAC inhibitors, have been studied either as monotherapy or in combination with X-ray irradiation or chemother
Externí odkaz:
https://doaj.org/article/bb96c7c5a6604a32ba72fbf2dcbd4fd0
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 602 (2024)
Histone deacetylases inhibitors (HDACis) have shown promising therapeutic outcomes in haematological malignancies such as leukaemia, multiple myeloma, and lymphoma, with disappointing results in solid tumours when used as monotherapy. As a result, co
Externí odkaz:
https://doaj.org/article/c2a5501dd85d40829b33f3e84711008d
Autor:
Monique Engelbrecht, Roya Ndimba, Xanthene Miles, Shankari Nair, Matthys Hendrik Botha, Elbie Zwanepoel, Evan de Kock, Maryna de Kock, Charlot Vandevoorde
Publikováno v:
Radiation, Vol 2, Iss 1, Pp 1-16 (2021)
Children have an increased risk of developing radiation-induced secondary malignancies compared to adults, due to their high radiosensitivity and longer life expectancy. In contrast to the epidemiological evidence, there is only a handful of radiobio
Externí odkaz:
https://doaj.org/article/e88b972220c34f1e93cf83f8cf1b109f
Autor:
Monique Engelbrecht, Roya Ndimba, Maryna de Kock, Xanthene Miles, Shankari Nair, Randall Fisher, Peter du Plessis, Julie Bolcaen, Matthys Hendrik Botha, Elbie Zwanepoel, Simon Sioen, Ans Baeyens, Jaime Nieto-Camero, Evan de Kock, Charlot Vandevoorde
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The radiosensitivity of haematopoietic stem and progenitor cells (HSPCs) to neutron radiation remains largely underexplored, notwithstanding their potential role as target cells for radiation-induced leukemogenesis. New insights are required
Externí odkaz:
https://doaj.org/article/cca29adbc16941058100fd83ea8d1a73
Autor:
Randall Fisher, Bjorn Baselet, Randy Vermeesen, Marjan Moreels, Sarah Baatout, Farzana Rahiman, Xanthene Miles, Shankari Nair, Peter du Plessis, Monique Engelbrecht, Roya J. Ndimba, Julie Bolcaen, Jaime Nieto-Camero, Evan de Kock, Charlot Vandevoorde
Publikováno v:
Frontiers in Physics, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/764b38a939614df693584ce64ce3a232
Estimating the Relative Biological Effectiveness of Auger Electron Emitter 123I in Human Lymphocytes
Autor:
Hein Fourie, Shankari Nair, Xanthene Miles, Daniel Rossouw, Philip Beukes, Richard T. Newman, Jan Rijn Zeevaart, Charlot Vandevoorde, Jacobus Slabbert
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
Auger electron emitters are considered to be a promising strategy for targeted radionuclide therapy of metastatic diseases, given their high linear energy transfer (LET) and short range in tissue which could potentially limit normal tissue toxicity.
Externí odkaz:
https://doaj.org/article/375f13f1512b4b59af7030300521cbfb
Autor:
Randall Fisher, Bjorn Baselet, Randy Vermeesen, Marjan Moreels, Sarah Baatout, Farzana Rahiman, Xanthene Miles, Shankari Nair, Peter du Plessis, Monique Engelbrecht, Roya J. Ndimba, Julie Bolcaen, Jaime Nieto-Camero, Evan de Kock, Charlot Vandevoorde
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
A better understanding of the combined impact of different space stressors on human health is urgently warranted, considering the upcoming long-duration missions beyond lower Earth orbit. Therefore, a growing number of particle accelerator facilities
Externí odkaz:
https://doaj.org/article/fdc72cce3b9f4267831a85494dfd18d6
Autor:
Julie Bolcaen, Shankari Nair, Cathryn H. S. Driver, Tebatso M. G. Boshomane, Thomas Ebenhan, Charlot Vandevoorde
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 626 (2021)
Glioblastoma (GB) remains the most fatal brain tumor characterized by a high infiltration rate and treatment resistance. Overexpression and/or mutation of receptor tyrosine kinases is common in GB, which subsequently leads to the activation of many d
Externí odkaz:
https://doaj.org/article/ab889b251d824d3b8fa44e854c2cc74a
Autor:
Mamoalosi A. Selepe, Phaladi Kunyane, Pule Seboletswe, Shankari Nair, Nosipho Cele, Monique Engelbrecht, Daniël F. Joubert, Charlot Vandevoorde, Parvesh Singh, Molahlehi S. Sonopo
Publikováno v:
Bioorganic chemistry. 128
Isoflavone derivatives were prepared from benzoylbenzofuran precursors. The synthesized compounds were analyzed by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, as well as high-resolution mass spectrometry (HRMS) to confirm their structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4451661adb0860a620f1b6f900cb0727
https://pubmed.ncbi.nlm.nih.gov/35998518
https://pubmed.ncbi.nlm.nih.gov/35998518
Publikováno v:
Arkivoc. 2020:90-102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10546a9fa6c95abfaa96a9693169ab26
https://doi.org/10.24820/ark.5550190.p011.260
https://doi.org/10.24820/ark.5550190.p011.260