Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shankar Varadarajan"'
Autor:
Daric J. Wible, Zalak Parikh, Eun Jeong Cho, Miao-Der Chen, Collene R. Jeter, Somshuvra Mukhopadhyay, Kevin N. Dalby, Shankar Varadarajan, Shawn B. Bratton
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract p38 mitogen-activated protein kinases (MAPKs) participate in autophagic signaling; and previous reports suggest that pyridinyl imidazole p38 MAPK inhibitors, including SB203580 and SB202190, induce cell death in some cancer cell-types throug
Externí odkaz:
https://doaj.org/article/d44578e962124c259e90c2981820c4c4
Autor:
Koustubh Ranade, Laura Collins, Adel Benlahrech, Aleksandra Raczka, Sophie Khakoo, Shankar Varadarajan, James Clubley
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/de7b50c3ad4547f694063e4691b6118a
Autor:
Rachel J. Carter, Mateus Milani, Alison J. Beckett, Shiyu Liu, Ian A. Prior, Gerald M. Cohen, Shankar Varadarajan
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-13 (2022)
Abstract The recruitment of DRP1 to mitochondrial membranes prior to fission is facilitated by the wrapping of endoplasmic reticulum (ER) membranes around the mitochondria. To investigate the complex interplay between the ER membranes and DRP1 in the
Externí odkaz:
https://doaj.org/article/18a54fa33ee1436389ec7df75e673145
Autor:
Fern Baedyananda, Thanayod Sasivimolrattana, Arkom Chaiwongkot, Shankar Varadarajan, Parvapan Bhattarakosol
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Cervical cancer is the fourth most common cancer in women worldwide. More than 90% of cases are caused by the human papillomavirus (HPV). Vaccines developed only guard against a few HPV types and do not protect people who have already been infected.
Externí odkaz:
https://doaj.org/article/86f3071602da488bacd83ce08fffc6d3
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260841 (2021)
HPV16 is the most prominent cause of cervical cancer. HPV16 E1, a helicase required for HPV replication exhibits increased expression in association with cervical cancer progression, suggesting that E1 has a similar effect on the host as the HPV16 E6
Externí odkaz:
https://doaj.org/article/6d9ec0d1ccc44155be92fd8e7653d1cb
Autor:
Aoula Al-Zebeeby, Meike Vogler, Mateus Milani, Caitlin Richards, Ahoud Alotibi, Georgia Greaves, Martin J.S. Dyer, Gerald M. Cohen, Shankar Varadarajan
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
BH3 mimetics are novel targeted drugs with remarkable specificity, potency and enormous potential to improve cancer therapy. However, acquired resistance is an emerging problem. We report the rapid development of resistance in chronic lymphocytic leu
Externí odkaz:
https://doaj.org/article/c27b4222c74a400291931a6b41c79ee2
Autor:
Shankar Varadarajan, Michael Butterworth, Jun Wei, Maurizio Pellecchia, David Dinsdale, Gerald M Cohen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 5, Pp 568-578 (2013)
Owing to the high levels of antiapoptotic B-cell lymphoma 2 (BCL-2) family members observed in several cancers, there has been a major effort to develop inhibitors of the BCL2-family as chemotherapeutic agents. Of the different members in the BCL-2 f
Externí odkaz:
https://doaj.org/article/f2f4ef9c6a7048408511dabd5360a6e6
Autor:
Shankar Varadarajan, Kayoko Tanaka, Joshua L Smalley, Edward T W Bampton, Maurizio Pellecchia, David Dinsdale, Gary B Willars, Gerald M Cohen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56603 (2013)
Recently we described a new, evolutionarily conserved cellular stress response characterized by a reversible reorganization of endoplasmic reticulum (ER) membranes that is distinct from canonical ER stress and the unfolded protein response (UPR). Apo
Externí odkaz:
https://doaj.org/article/f2f1af8d7f7742d48a94c649482d40f4
It has now become increasingly clear that viruses, which may not be directly oncogenic, can affect the biology of tumors as well as immune behavior against tumors. This has led to a fundamental question: Should tumors associated with viral infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36577e6d2c59157a6ae3c233f422412d
https://doi.org/10.1158/0008-5472.c.6513438.v1
https://doi.org/10.1158/0008-5472.c.6513438.v1
Supplemental Figure 1. TMEM173 gene encoding STING expression across HPV+ and HPV- HNSCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23725f47ebb032f4d4ae1c781f158b55
https://doi.org/10.1158/0008-5472.22429704.v1
https://doi.org/10.1158/0008-5472.22429704.v1