Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Shankar P. Parajuli"'
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141950 (2015)
Estrogen replacement therapies have been suggested to be beneficial in alleviating symptoms of overactive bladder. However, the precise regulatory mechanisms of estrogen in urinary bladder smooth muscle (UBSM) at the cellular level remain unknown. La
Externí odkaz:
https://doaj.org/article/eb1f34b2d23646bca35d287a1c219268
Autor:
Kiril L Hristov, Serge A Y Afeli, Shankar P Parajuli, Qiuping Cheng, Eric S Rovner, Georgi V Petkov
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68052 (2013)
Patients suffering from a variety of neurological diseases such as spinal cord injury, Parkinson's disease, and multiple sclerosis often develop neurogenic detrusor overactivity (NDO), which currently lacks a universally effective therapy. Here, we t
Externí odkaz:
https://doaj.org/article/3b036dc0e57e46bea377384bc04de2e0
Autor:
Shankar P. Parajuli, J. Kevin Donahue
Current treatment for ventricular arrhythmias with antiarrhythmic drugs, implantable cardioverter defibrillators, or radiofrequency ablation has limited efficacy and detrimental impact on the quality of life. Gene and cell therapy have promising prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77906cc4ba30446efa0738e3ff91a57b
https://doi.org/10.1016/b978-0-12-813704-8.00032-2
https://doi.org/10.1016/b978-0-12-813704-8.00032-2
Autor:
Amir AbdelWahab, Kedar K. Aras, Rishi Arora, Latib Azeem, Ronald D. Berger, James C. Blankenship, Gerard J.J. Boink, Davide Bolignano, Dana Boucek, Tobias Brügmann, Doron Bushi, Sheena W. Chen, Vincent M. Christoffels, Michel Corban, Regazzoli Damiano, Debabrata Dash, Robert David, Antoine A.F. de Vries, Harsha D. Devalla, J. Kevin Donahue, Igor R. Efimov, Abdallah El-Sabbagh, Giannini Francesco, Ponticelli Francesco, Paul Friedman, Dirk Geerts, M. Imran Ghare, Kashish Goel, Marie José T.H. Goumans, Robert Gray, Gallone Guglielmo, Stephanie El Hajj, Jacob A Hoffman, David R. Holmes, Jr, Erik W. Holy, Richard P. Jones, II, Johanna P. Laakkonen, Alexandra Lansky, K. Benjamin Lee, Mark S Link, Baldetti Luca, Gramegna Mario, Bernhard Meier, Dr Rohit Mody, Christine L Mummery, Fabian Nietlispach, Udi Nussinovitch, Emile Nyns, Jeffrey S. Panting, Shankar P. Parajuli, Nimesh Patel, Daniël A. Pijnappels, Abhiram Prasad, T. Alexander Quinn, Claire E. Raphael, Elon Reshef, Avi Sabbag, John Sapp, Philipp Sasse, Mark J. Schneider, Hanno L. Tan, Daniela Tirziu, Amar Trivedi, Anna M.D. Végh, Chance Witt, Rose T. Yin, Seppo Ylä-Herttuala, Shanshan Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049488fd5097a89d1e16ce9f528e0dfe
https://doi.org/10.1016/b978-0-12-813704-8.00050-4
https://doi.org/10.1016/b978-0-12-813704-8.00050-4
Publikováno v:
Channels. 10:355-364
Contraction and relaxation of urinary bladder smooth muscle cells (UBSMCs) represent the important physiological functions of the bladder. Contractile responses in UBSMCs are regulated by a number of ion channels including big-conductance Ca2+- activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19086e800963806b26646cac5bb7072f
https://doi.org/10.1080/19336950.2016.1180488
https://doi.org/10.1080/19336950.2016.1180488
Autor:
Georgi V. Petkov, Shankar P. Parajuli, Amy C. Smith, Kiril L. Hristov, John Malysz, Eric S. Rovner
Publikováno v:
American Journal of Physiology-Cell Physiology. 310:C600-C611
Transient receptor potential melastatin 4 (TRPM4) channels are Ca2+-activated nonselective cation channels that have been recently identified as regulators of detrusor smooth muscle (DSM) function in rodents. However, their expression and function in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc9d077280340668a4641d516437ce1
https://doi.org/10.1152/ajpcell.00270.2015
https://doi.org/10.1152/ajpcell.00270.2015
Autor:
Chan Guk Park, Chansik Hong, Jae Yeoul Jun, Il Koo Park, Seok Choi, Jin Ho Kim, Man Yoo Kim, Shankar P. Parajuli
Publikováno v:
Chonnam Medical Journal
Purinergic receptors play an important role in regulating gastrointestinal (GI) motility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate GI smooth muscle activity. We studied the functional roles of external adenosine 5'-triphos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e9bcf6fe090a3cf48ed5576f975755
https://pubmed.ncbi.nlm.nih.gov/29399568
https://pubmed.ncbi.nlm.nih.gov/29399568
Publikováno v:
Physiological Reports
Estrogens have an important role in regulating detrusor smooth muscle (DSM) function. However, the underlying molecular and cellular mechanisms by which estrogens control human DSM excitability and contractility are not well known. Here, we used huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f02105bb64e8b505cf831ad6d8916e9d
https://pubmed.ncbi.nlm.nih.gov/28754781
https://pubmed.ncbi.nlm.nih.gov/28754781
Publikováno v:
European Journal of Pharmacology. 738:179-185
Prostaglandin E2 (PGE2) is an essential signaling molecule involved in the regulation of detrusor smooth muscle (DSM) function. However, the underlying regulatory mechanism by which PGE2 augments DSM cell excitability and contractility is not well un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c504dfcd850814ff2176b10058caee
https://doi.org/10.1016/j.ejphar.2014.05.042
https://doi.org/10.1016/j.ejphar.2014.05.042
Autor:
Kiril L. Hristov, Eric S. Rovner, Georgi V. Petkov, Qiuping Cheng, Shankar P. Parajuli, John Malysz
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 467:665-675
Activation of muscarinic acetylcholine receptors (mAChRs) constitutes the primary mechanism for enhancing excitability and contractility of human detrusor smooth muscle (DSM). Since the large-conductance Ca(2+)-activated K(+) (KCa1.1) channels are ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ddc5d04936cb8a45dd3d7de3d00790
https://doi.org/10.1007/s00424-014-1537-8
https://doi.org/10.1007/s00424-014-1537-8