Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shankar Manyem"'
Autor:
Vladimir Bartus, Gregory R. Cook, Viera Lukacova, Xiaomin Jin, Mukund P. Sibi, Shankar Manyem, Sandeep R. Ghorpade, Yufen Zhang, Ethirajan Manivannan, Xiaoping Nie, Guorong Sun, Stefan Balaz
Publikováno v:
Chemical Biology & Drug Design. 72:237-248
Binding to the extracellular matrix, one of the most abundant human protein complexes, significantly affects drug disposition. Specifically, the interactions with extracellular matrix determine the free concentrations of small molecules acting in tis
Publikováno v:
ARKIVOC, Vol 2006, Iss 4, Pp 189-199 (2006)
Scopus-Elsevier
Scopus-Elsevier
Treatment of an oxaziridine with low-valent iron or copper salts generates a carbon-centered radical able to cyclize onto an appended olefin.
Publikováno v:
Tetrahedron. 59:10575-10580
Radical additions to oxazolidinone acrylate followed by allyl trapping were studied with chiral Lewis acids derived from lanthanide salts. Chiral ligands were evaluated to establish the α-stereocenter. Ligands with a prolinol framework along with ac
Autor:
Mukund P. Sibi, Shankar Manyem
Publikováno v:
Tetrahedron. 56:8033-8061
Autor:
Benjamin Neuenswander, Frank J. Schoenen, Jeffrey Aubé, Mukund P. Sibi, Shankar Manyem, Gerald H. Lushington
Publikováno v:
ChemInform. 38
A parallel synthesis of a library (80 members) of 2-pyrazolines in solution phase is described. The 2-pyrazoline core was accessed through the [3 + 2] cycloaddition of nitrilimines with enoyl oxazolidinones. The cycloaddition provided two regioisomer
Publikováno v:
Journal of the American Chemical Society. 128(42)
The concept of "fluxional additives", additives that can adopt enantiomeric conformations depending on the chiral information in the ligand, is demonstrated in enantioselective Diels-Alder and nitrone cycloaddition reactions. The additive design is m
Publikováno v:
ChemInform. 35
Publikováno v:
ChemInform. 35
Publikováno v:
ChemInform. 34
In ligand design for asymmetric catalysis, the usual norm is to derive the face shielding elements from a chiral source. New ligands in which the face shielding is determined by fluxional groups are introduced. Their design, modular synthesis, and ex
Publikováno v:
Chemical reviews. 103(8)