Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Shankar BB"'
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6
Akademický článek
Development of a prodrug of hydantoin based TACE inhibitor.
Autor: Tong L; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: ling.tong@merck.com., Kim SH; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Chen L; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Kosinski A; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Shankar BB; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Girijavallabhan V; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Yang DY; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Yu W; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Zhou G; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Shih NY; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Chen S; Department of PPDM, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Hu M; Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Lundell D; Department of Immunology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Niu X; Department of Immunology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Umland S; Department of Immunology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Kozlowski JA; Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Aug 15; Vol. 27 (16), pp. 3704-3708. Date of Electronic Publication: 2017 Jul 03.
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7
Akademický článek
Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.
Autor: Tong L; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: ling.tong@merck.com., Kim SH; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Rosner K; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Yu W; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Shankar BB; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Chen L; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Li D; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Dai C; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Girijavallabhan V; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Popovici-Muller J; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Yang L; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Zhou G; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Kosinski A; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Siddiqui MA; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Shih NY; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Guo Z; Department of Chemistry, Modeling and Informatics, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Orth P; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Chen S; Department of Pharmacokinetics, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Lundell D; Department of Immunology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Niu X; Department of Immunology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Umland S; Department of Immunology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Kozlowski JA; Department of Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA; Department of Chemistry, Modeling and Informatics, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA; Department of Pharmacokinetics, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA; Department of Immunology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jul 15; Vol. 27 (14), pp. 3037-3042. Date of Electronic Publication: 2017 May 22.
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8
Akademický článek
Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors.
Autor: Tong L; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA. Electronic address: ling.tong@merck.com., Yu W; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Coburn CA; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Chen L; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Selyutin O; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Zeng Q; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Dwyer MP; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Nair AG; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Shankar BB; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Kim SH; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Yang DY; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Rosenblum SB; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Ruck RT; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Davies IW; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Hu B; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, China., Zhong B; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, China., Hao J; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, China., Ji T; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, China., Zan S; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, China., Liu R; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Agrawal S; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Carr D; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Curry S; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., McMonagle P; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Bystol K; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Lahser F; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Ingravallo P; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Chen S; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Asante-Appiah E; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA., Kozlowski JA; Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Nov 01; Vol. 26 (21), pp. 5354-5360. Date of Electronic Publication: 2016 Sep 02.
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9
Akademický článek
Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.
Autor: Dwyer MP; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA. Electronic address: michael.dwyer@merck.com., Keertikar KM; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Chen L; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Tong L; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Selyutin O; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Nair AG; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Yu W; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Zhou G; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Lavey BJ; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Yang DY; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Wong M; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Kim SH; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Coburn CA; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Rosenblum SB; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Zeng Q; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Jiang Y; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Shankar BB; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Rizvi R; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Nomeir AA; Drug Metabolism, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Liu R; Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Agrawal S; Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Xia E; Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Kong R; Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Zhai Y; Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Ingravallo P; Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Asante-Appiah E; Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Kozlowski JA; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 15; Vol. 26 (16), pp. 4106-11. Date of Electronic Publication: 2016 Jun 25.
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10
Akademický článek
Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.
Autor: Yu W; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: wensheng.yu@merck.com., Coburn CA; Department of Medicinal Chemistry, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA., Nair AG; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Wong M; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Tong L; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Dwyer MP; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Hu B; WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China., Zhong B; WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China., Hao J; WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China., Yang DY; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Selyutin O; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Jiang Y; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Rosenblum SB; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Kim SH; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Lavey BJ; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Zhou G; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Rizvi R; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Shankar BB; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Zeng Q; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Chen L; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Agrawal S; Department of In Vitro Pharmacology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Carr D; Department of In Vitro Pharmacology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Rokosz L; Department of In Vitro Pharmacology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Liu R; Department of Infectious Diseases, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Curry S; Department of Infectious Diseases, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., McMonagle P; Department of Infectious Diseases, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Ingravallo P; Department of Infectious Diseases, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Lahser F; Department of Infectious Diseases, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Asante-Appiah E; Department of Infectious Diseases, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Nomeir A; Department of PPDM, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Kozlowski JA; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 01; Vol. 26 (15), pp. 3800-5. Date of Electronic Publication: 2016 May 14.
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