Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shankang Qi"'
Autor:
Runhua Du, Yanmei Gao, Cong Yan, Xuelian Ren, Shankang Qi, Guobin Liu, Xinlong Guo, Xiaohan Song, Hanmin Wang, Jingxin Rao, Yi Zang, Mingyue Zheng, Jia Li, He Huang
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110911- (2024)
Summary: Lysine lactylation (Kla), an epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, bridges metabolism and gene regulation. Enzymes such as p300 and HDAC1/3 have been pivotal in deciphering the regulatory dynam
Externí odkaz:
https://doaj.org/article/147e508e14044b2993e031fe035dec72
Autor:
Jian Li, Xiaoyu Li, Ming Li, Hong Qiu, Christian Saad, Bo Zhao, Fan Li, Xiaowei Wu, Dong Kuang, Fengjuan Tang, Yaobing Chen, Hongge Shu, Jing Zhang, Qiuxia Wang, He Huang, Shankang Qi, Changkun Ye, Amy Bryant, Xianglin Yuan, Christian Kurts, Guangyuan Hu, Weiting Cheng, Qi Mei
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Early diagnosis of lung cancer is critically important to reduce disease severity and improve overall survival. Newer, minimally invasive biopsy procedures often fail to provide adequate specimens for accurate tumor subtyping or staging whic
Externí odkaz:
https://doaj.org/article/a3efc8e3513544b98aa4f210f115aad6
Autor:
Doudou Tan, Wei Wei, Zhen Han, Xuelian Ren, Cong Yan, Shankang Qi, Xiaohan Song, Y. George Zheng, Jiemin Wong, He Huang
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105443- (2022)
Summary: Lysine benzoylation (Kbz) is a newly discovered protein post-translational modification (PTM). This PTM can be stimulated by benzoate and contributes to gene expression. However, its regulatory enzymes and substrate proteins remain largely u
Externí odkaz:
https://doaj.org/article/deb5b92a693a475c8c2f0fe0529a482d
Autor:
Jiang, Wang, Jing, Zhao, Cong, Yan, Cong, Xi, Chenglin, Wu, Jingxiang, Zhao, Fengwei, Li, Yanhua, Ding, Rui, Zhang, Shankang, Qi, Xingjun, Li, Chao, Liu, Wanting, Hou, Hong, Chen, Yiping, Wang, Dalei, Wu, Kaixian, Chen, Hualiang, Jiang, He, Huang, Hong, Liu
Publikováno v:
Yearbook of Paediatric Endocrinology.
Developing non-statin-based small compounds to battle the global epidemic of hyperlipidemia remains challenging. Here, we report the discovery of DC371739, an indole-containing tetrahydroisoquinoline compound with promising lipid-lowering effects, bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7346f7f73151589c1e2e7f8391665fb1
https://doi.org/10.1530/ey.19.12.11
https://doi.org/10.1530/ey.19.12.11
Publikováno v:
Oxidative medicine and cellular longevity. 2022
Lysine 2-hydroxyisobutyrylation (Khib) is a new type of posttranslational modifications (PTMs) extensively reported on eukaryotic cell histones. It is evolutionarily conserved and participates in diverse important biological processes, such as transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cbf885a8d263400860fd5250f2c7ea
https://pubmed.ncbi.nlm.nih.gov/35178156
https://pubmed.ncbi.nlm.nih.gov/35178156
Autor:
Chao Peng, Kyle Delaney, Philip A. Cole, Shankang Qi, He Huang, Robert G. Roeder, Di Zhang, Yingming Zhao, Yejing Weng, Zhanyun Tang, Cong Yan
Publikováno v:
Science Advances
Widespread lysine β-hydroxybutyrylation plays diverse regulatory roles and is reversibly regulated by p300 and HDAC1/2.
Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular signaling, in which lysine acetylation an
Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular signaling, in which lysine acetylation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f7f1d3a446c90bb2f34fcba704242a
https://doi.org/10.1126/sciadv.abe2771
https://doi.org/10.1126/sciadv.abe2771
Autor:
Shangming Du, Yingxia Li, He Huang, Guokun Zhang, Jian Li, Qi Mei, Kathrin Halfter, Shankang Qi, Guangyuan Hu, Xiaoyu Li, Christian Saad, Ulrich Mansmann, Weiting Cheng
Background: Currently, predicting treatment efficacy to immunotherapy has been under extensive investigation. However, a putative biomarker for immunotherapy in melanoma remains to be found.Methods: Utilizing genetic data from two independent melanom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad81dbcac7720f0edbb702e0447d5382
https://doi.org/10.21203/rs.3.rs-18122/v1
https://doi.org/10.21203/rs.3.rs-18122/v1
Autor:
Di Zhang, Zhanyun Tang, Saadi Khochbin, Zhongyi Cheng, Guillaume Charbonnier, Carlo Petosa, Sophie Barral, Anne-Laure Vitte, Sophie Rousseaux, Robert G. Roeder, Thierry Buchou, Yingming Zhao, Tieming He, Shankang Qi, Daniel Panne, Sandrine Curtet, Afsaneh Goudarzi, Emilie Montellier, Jonathan Gaucher, Alexandra Debernardi, Denis Puthier, He Huang, Oh Kwang Kwon
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2016, 62 (2), pp.169-80. ⟨10.1016/j.molcel.2016.03.014⟩
Molecular Cell, 2016, 62 (2), pp.169-80. ⟨10.1016/j.molcel.2016.03.014⟩
Molecular Cell, Elsevier, 2016, 62 (2), pp.169-80. ⟨10.1016/j.molcel.2016.03.014⟩
Molecular Cell, 2016, 62 (2), pp.169-80. ⟨10.1016/j.molcel.2016.03.014⟩
Summary Recently discovered histone lysine acylation marks increase the functional diversity of nucleosomes well beyond acetylation. Here, we focus on histone butyrylation in the context of sperm cell differentiation. Specifically, we investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cb886d8e824fe3bf09d65b4d3a15fa
Autor:
Xiaoyong Yang, Yue Chen, Scott D. Pletcher, Hai Bin Ruan, Zhanyun Tang, Lunzhi Dai, Chao Peng, Sangkyu Lee, Dan-Li Wang, Robert G. Roeder, Hongyu Zhao, Dongjun Chung, Di Zhang, Kevin P. White, Shankang Qi, Zhongyu Xie, David B. Lombard, Yingming Zhao, Matt Kirkey, Chunmei Xia, Minjia Tan, Gozde Colak, Jing-Ya Li, Lindy Jensen, He Huang, Jia Li, Oh Kwang Kwon
Publikováno v:
Molecular Cell. 62:194-206
Here we report the identification and verification of a β-hydroxybutyrate-derived protein modification, lysine β-hydroxybutyrylation (Kbhb), as a new type of histone mark. Histone Kbhb marks are dramatically induced in response to elevated β-hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4d2df3d959b10d008e5ded1008a3f5
https://doi.org/10.1016/j.molcel.2016.03.036
https://doi.org/10.1016/j.molcel.2016.03.036
Autor:
Lin Yu, Ye Tao, Jiwen Li, Zengqin Deng, Mingchu Xu, Zhongzhou Chen, Shankang Qi, Jiemin Wong, Qi Zhang, Wei Wu
Publikováno v:
Cell Research. 23:225-241
LSD2/AOF1/KDM1b catalyzes demethylation of mono- and di-methylated H3K4 and plays an important role in transcriptional regulation and genomic imprinting. Here, we report the high-resolution crystal structures of apo-LSD2 and LSD2 in complex with a pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4fbd90982b37bdb8ebf1f7cd700b71
https://doi.org/10.1038/cr.2012.177
https://doi.org/10.1038/cr.2012.177