Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shanique, Alabi"'
Autor:
Shanique Alabi, Saul Jaime-Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T. G. Samarasinghe, Lea Vogt, Neal Rosen, Craig M. Crews
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Hundreds of BRAF mutations have been identified in patients with cancer but currently approved drugs only target BRAF V600 mutants. Here, the authors develop a vemurafenib-based PROTAC that induces degradation of all classes of BRAF mutants without a
Externí odkaz:
https://doaj.org/article/c199e2f0eb92437a873d93ab5b38d197
Autor:
Shanique Alabi
Publikováno v:
Biochemistry. 60:2371-2373
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfe73a694cd78a52c2779defb1cd486
https://doi.org/10.1021/acs.biochem.1c00353
https://doi.org/10.1021/acs.biochem.1c00353
Autor:
Craig M. Crews, Neal Rosen, Yijun Gao, John Hines, Zhan Yao, Kusal T. G. Samarasinghe, Shanique Alabi, Saul Jaime-Figueroa, Lea Vogt
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Over 300 BRAF missense mutations have been identified in patients, yet currently approved drugs target V600 mutants alone. Moreover, acquired resistance inevitably emerges, primarily due to RAF lesions that prevent inhibition of BRAF V600 with curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c111d9b909a29cba6e4517c0f5003c
https://doi.org/10.1038/s41467-021-21159-7
https://doi.org/10.1038/s41467-021-21159-7
Autor:
Laura I. van Dyck, Dipal Nagda, Avner Schlessinger, Sofia B. Lizarraga, Abbie M. Maguire, Michael Schmidt, Diane Hoffman-Kim, Qing Wu, Paul Brito-Vargas, Mara H. Cowen, Liane L. Livi, Li Ma, Matthew F. Pescosolido, Qing Ouyang, Ece D. Gamsiz Uzun, Shanique Alabi, Brian C. Kavanaugh, Eric M. Morrow, Richard N. Jones
Publikováno v:
Sci Transl Med
Christianson syndrome (CS), an X-linked neurological disorder characterized by postnatal attenuation of brain growth (postnatal microcephaly), is caused by mutations in SLC9A6 (also termed NHE6), the gene encoding endosomal Na(+)/H(+) exchanger 6 (NH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb7b13f6232a78e35636cba1bfae712
https://doi.org/10.1126/scitranslmed.aaw0682
https://doi.org/10.1126/scitranslmed.aaw0682
Human neurons from Christianson syndrome iPSCs reveal allele-specific responses to rescue strategies
Autor:
Abbie M. Maguire, Qing Wu, Matthew F. Pescosolido, Michael Schmidt, Sofia B. Lizarraga, Avner Schlessinger, Eric M. Morrow, Laura I. van Dyck, Li Ma, Richard N. Jones, Ece D Gamzis Uzun, Mara H. Cowen, Paul Brito-Vargas, Dipal Nagda, Shanique Alabi, Liane L. Livi, Diane Hoffman-Kim
Human genetic disorders provide a powerful lens to understanding the human brain. Induced pluripotent stem cells (iPSC) represent an important, new resource for mechanistic studies and therapeutic development. Christianson syndrome (CS), an X-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0155d26047d52f7cb62a62ca1eebcc
https://doi.org/10.1101/444232
https://doi.org/10.1101/444232
Publikováno v:
The Journal of biological chemistry. 291(13)
Polynucleotide phosphorylase (PNPase), a 3′-to-5′ phosphorolytic exoribonuclease, is thought to be the primary enzyme responsible for turnover of Bacillus subtilis mRNA. The role of PNPase in B. subtilis mRNA decay has been analyzed previously by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8c22a29545326515912af4a2c66de0e
https://pubmed.ncbi.nlm.nih.gov/26797123
https://pubmed.ncbi.nlm.nih.gov/26797123