Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Shani L, Frayo"'
Autor:
Oliver W. Press, K. Dane Wittrup, D. Scott Wilbur, Kelly D. Orcutt, Shyril O'Steen, Brian G. Till, Johnnie J. Orozco, Theodore A. Gooley, Ajay K. Gopal, Mark D. Hylarides, Aimee L. Kenoyer, Sofia H.L. Frost, Darrell R. Fisher, Donald K. Hamlin, Yukang Lin, Shani L. Frayo, Damian J. Green
Figures including: Supplemental Figure 1- Dose finding pharmacokinetics. Supplemental Figure 2- Dose finding tissue biodistribution. Supplemental Figure 3- body weight over time in a therapy study. Supplemental Figure 4- blood counts over time in a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fa9ad6c582f79e53958516ac3c2d49
https://doi.org/10.1158/0008-5472.22413027
https://doi.org/10.1158/0008-5472.22413027
Autor:
Oliver W. Press, K. Dane Wittrup, D. Scott Wilbur, Kelly D. Orcutt, Shyril O'Steen, Brian G. Till, Johnnie J. Orozco, Theodore A. Gooley, Ajay K. Gopal, Mark D. Hylarides, Aimee L. Kenoyer, Sofia H.L. Frost, Darrell R. Fisher, Donald K. Hamlin, Yukang Lin, Shani L. Frayo, Damian J. Green
Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dc53f403d5241580b8113781f0a0c07
https://doi.org/10.1158/0008-5472.c.6508593.v1
https://doi.org/10.1158/0008-5472.c.6508593.v1
Autor:
Oliver W. Press, William I. Bensinger, Brent L. Wood, Theodore A. Gooley, Johnnie J. Orozco, Ajay K. Gopal, Shani L. Frayo, Aimee L. Kenoyer, Darrell R. Fisher, Yukang Lin, D.S. Wilbur, Donald K. Hamlin, John M. Pagel, Mark D. Hylarides, Jon C. Jones, Nural N. Orgun, Damian J. Green
The vast majority of patients with plasma cell neoplasms die of progressive disease despite high response rates to novel agents. Malignant plasma cells are very radiosensitive, but the potential role of radioimmunotherapy (RIT) in the management of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5e44fccb2ce33ee2561644e5b6427e
https://doi.org/10.1158/0008-5472.c.6505673
https://doi.org/10.1158/0008-5472.c.6505673
Autor:
Oliver W. Press, William I. Bensinger, Brent L. Wood, Theodore A. Gooley, Johnnie J. Orozco, Ajay K. Gopal, Shani L. Frayo, Aimee L. Kenoyer, Darrell R. Fisher, Yukang Lin, D.S. Wilbur, Donald K. Hamlin, John M. Pagel, Mark D. Hylarides, Jon C. Jones, Nural N. Orgun, Damian J. Green
PDF - 156K, Supplementary Figure 1, demonstrating CD38 receptor surface stability. Supplementary Figure 2, demonstrating animal body weight following anti-CD38 pretargeted radioimmunotherapy. Supplemental methods describing fusion protein constructio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4838aea0b499623f63cad0d93d2dbf00
https://doi.org/10.1158/0008-5472.22400780
https://doi.org/10.1158/0008-5472.22400780
Autor:
Sofia H L Frost, Shani L Frayo, Brian W Miller, Johnnie J Orozco, Garrett C Booth, Mark D Hylarides, Yukang Lin, Damian J Green, Ajay K Gopal, John M Pagel, Tom A Bäck, Darrell R Fisher, Oliver W Press
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120561 (2015)
Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising
Externí odkaz:
https://doaj.org/article/feaef0190b0a45d09f0422717c6da81b
Autor:
Ted Gooley, Stephen D. Smith, John M. Pagel, George R. Oliveira, Phillip A. Stevenson, Jennifer E. Roden, Brent L. Wood, Andrew J. Cowan, Damian J. Green, Shani L. Frayo, Oliver W. Press, Ajay K. Gopal
Publikováno v:
British Journal of Haematology. 176:583-590
Fenretinide, a synthetic retinoid, induces apoptotic cell death in B-cell non-Hodgkin lymphoma (B-NHL) and acts synergistically with rituximab in preclinical models. We report results from a phase I-II study of fenretinide with rituximab for B-NHLs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0136c59e32b24d390bb009913ab54e
https://doi.org/10.1111/bjh.14451
https://doi.org/10.1111/bjh.14451
Autor:
Brian W. Miller, Sofia H.L. Frost, Tom Bäck, Sue E. Knoblaugh, Aimee L. Kenoyer, Erlinda B. Santos, Brenda M. Sandmaier, Shani L. Frayo, Donald K. Hamlin, John M. Pagel, Rainer Storb, D. Scott Wilbur, Oliver W. Press
Publikováno v:
Journal of Nuclear Medicine. 56:1766-1773
α-radioimmunotherapy targeting CD45 may substitute for total-body irradiation in hematopoietic cell transplantation (HCT) preparative regimens for lymphoma. Our goal was to optimize the anti-CD45 monoclonal antibody (mAb; CA12.10C12) protein dose fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e01976fdd492234aaa81ad9a8efc17fd
https://doi.org/10.2967/jnumed.115.162388
https://doi.org/10.2967/jnumed.115.162388
Autor:
Sofia H.L. Frost, D. Scott Wilbur, Erlinda B. Santos, Brian W. Miller, Oliver W. Press, Johnnie J. Orozco, Donald K. Hamlin, Brenda M. Sandmaier, John M. Pagel, Damian J. Green, Darrell R. Fisher, Shani L. Frayo, Aimee L. Kenoyer, Jon C. Jones
Publikováno v:
Medical Physics. 42:4094-4105
Purpose: Alpha-emitting radionuclides exhibit a potential advantage for cancer treatments because they release large amounts of ionizing energy over a few cell diameters (50–80 μm), causing localized, irreparable double-strand DNA breaks that lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13ed41d650de153f66f73c85661e4c93
https://doi.org/10.1118/1.4921997
https://doi.org/10.1118/1.4921997
Autor:
D. Scott Wilbur, Mazyar Shadman, Aimee L. Kenoyer, Yukang Lin, Brian W. Miller, Oliver W. Press, Damian J. Green, Tom Bäck, Donald K. Hamlin, Brenda M. Sandmaier, John M. Pagel, Shani L. Frayo, Mark D. Hylarides, Kelly L. Laird, Ajay K. Gopal, Ethan R. Balkan, Ted Gooley, Brian G. Till, Sofia H.L. Frost, Johnnie J. Orozco, Jon C. Jones
Publikováno v:
Blood. 125:2111-2119
α-Emitting radionuclides deposit a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD). To evaluate this hypothesis, (211)At-labeled 1F5 monoclonal anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b089f0ed02ecbd3e817b7657cc75ac
https://doi.org/10.1182/blood-2014-11-612770
https://doi.org/10.1182/blood-2014-11-612770
Autor:
Anthony J. Convertine, Yifan Song, Betty W. Shen, David Baker, Erik Procko, William R. Schief, Patrick S. Stayton, Barry L. Stoddard, Shani L. Frayo, Bruno E. Correia, Oliver W. Press, Garrett C. Booth, Geoffrey Y. Berguig, Daciana Margineantu, David M. Hockenbery, Yuanhua Cheng
Publikováno v:
Cell. 157:1644-1656
SummaryBecause apoptosis of infected cells can limit virus production and spread, some viruses have co-opted prosurvival genes from the host. This includes the Epstein-Barr virus (EBV) gene BHRF1, a homolog of human Bcl-2 proteins that block apoptosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4ffdd90f4c19471f8ebbf2c0f87e56
https://doi.org/10.1016/j.cell.2014.04.034
https://doi.org/10.1016/j.cell.2014.04.034