Human Multi-Compartment Airways-on-Chip Platform for Emulating Respiratory Airborne Transmission: From Nose to Pulmonary Acini

Autor: Eliram Nof, Hikaia Zidan, Arbel Artzy-Schnirman, Odelia Mouhadeb, Margarita Beckerman, Saurabh Bhardwaj, Shani Elias-Kirma, Didi Gur, Adi Beth-Din, Shulamit Levenberg, Netanel Korin, Arie Ordentlich, Josué Sznitman

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

The past decade has witnessed tremendous endeavors to deliver novel preclinical in vitro lung models for pulmonary research endpoints, including foremost with the advent of organ- and lung-on-chips. With growing interest in aerosol transmission and i

Externí odkaz: https://doaj.org/article/17ab825162e14ff4a2babf2e66f1b7cf

Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity.

Autor: Alexey A Gritsenko, Shira Weingarten-Gabbay, Shani Elias-Kirma, Ronit Nir, Dick de Ridder, Eran Segal

Publikováno v: PLoS Computational Biology, Vol 13, Iss 9, p e1005734 (2017)

Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when

Externí odkaz: https://doaj.org/article/aef8145668354acebc52a826d8e5e7cd

In situ-Like Aerosol Inhalation Exposure for Cytotoxicity Assessment Using Airway-on-Chips Platforms

Autor: Netanel Korin, Shani Elias-Kirma, Josué Sznitman, Prashant Das, Arbel Artzy-Schnirman, Metar Heller-Algazi

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Frontiers in Bioengineering and Biotechnology

Lung exposure to inhaled particulate matter (PM) is known to injure the airway epithelium via inflammation, a phenomenon linked to increased levels of global morbidity and mortality. To evaluate physiological outcomes following PM exposure and concur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9922fdf0db4759fb6d53b52ae861a8fe
https://www.frontiersin.org/article/10.3389/fbioe.2020.00091/full

Systematic discovery of cap-independent translation sequences in human and viral genomes

Autor: Alexey A. Gritsenko, Zohar Yakhini, Eran Segal, Shani Elias-Kirma, Adina Weinberger, Shira Weingarten-Gabbay, Ronit Nir, Noam Stern-Ginossar

Publikováno v: Science. 351

INTRODUCTION The recruitment of the ribosome to a specific mRNA is a critical step in the production of proteins in cells. In addition to a general recognition of the “cap” structure at the beginning of eukaryotic mRNAs, ribosomes can also initia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16dc065d1861bb7225f3ec610368ec27
https://doi.org/10.1126/science.aad4939

Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity

Autor: Shani Elias-Kirma, Shira Weingarten-Gabbay, Dick de Ridder, Eran Segal, Alexey A. Gritsenko, Ronit Nir

Publikováno v: PLoS Computational Biology (Print), 13(9)
PLoS Computational Biology, Vol 13, Iss 9, p e1005734 (2017)
PLoS Computational Biology, 13(9)
PLoS Computational Biology 13 (2017) 9
PLoS Computational Biology

Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36fd8638c773a48b6bef52606a0a75f
https://doi.org/10.1371/journal.pcbi.1005734