Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shani Austin-Williams"'
Autor:
Purbasha Bhattacharya, Umesh Kumar Dhawan, Mohammed Tayab Hussain, Praveen Singh, Karran Kiran Bhagat, Aarushi Singhal, Shani Austin-Williams, Shantanu Sengupta, Manikandan Subramanian
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112808- (2023)
Summary: Macrophages release soluble mediators following efferocytic clearance of apoptotic cells to facilitate intercellular communication and promote the resolution of inflammation. However, whether inflammation resolution is modulated by extracell
Externí odkaz:
https://doaj.org/article/30f5b62bc1714268a36dfafb30924b3c
Autor:
Jianmin Chen, Shani Austin-Williams, Caroline Elizabeth O'Riordan, Pol Claria-Ribas, Michelle A Sugimoto, Lucy V Norling, Christoph Thiemermann, Mauro Perretti
Publikováno v:
Journal of Innate Immunity (2023)
Using a global formyl-peptide receptor (Fpr)2 knockout mouse colony, we have reported the modulatory properties of this pro-resolving receptor in polymicrobial sepsis. Herein, we have used a humanized FPR2 (hFPR2) mouse colony bearing an intact or a
Externí odkaz:
https://doaj.org/article/b421d54d872143dba7cc03c90dc816d1
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Extracellular vesicles are a heterogeneous family of vesicles, generated from different subcellular compartments and released into the extracellular space. Composed of a lipid bilayer encompassing both soluble cytosolic material and nuclear component
Externí odkaz:
https://doaj.org/article/5c0bf3b51ff54e578d4a8721ab5d2d11
Autor:
Holly Rocliffe, Shani Austin-Williams, Georgios Krilis, Kanheng Zhou, Yubo Ji, Connor Bain, Yonlada Nawilaijaroen, Antonella Pellicoro, Tianchi Zhou, Michael Crichton, Zhihong Huang, Andrea Caporali, Jenna L Cash
Cutaneous wound healing typically results in scarring; however, chronic wounds (CWs) represent a global and escalating health burden causing substantial morbidity and mortality. Estimated to cost Medicare up to $96.8 billion pa and with a profound pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07c298628de7f21197ee804719bdedc4
https://doi.org/10.1101/2022.11.30.518516
https://doi.org/10.1101/2022.11.30.518516
Autor:
Roberta De Matteis, Magdalena B. Flak, Maria Gonzalez-Nunez, Shani Austin-Williams, Francesco Palmas, Romain A. Colas, Jesmond Dalli
Publikováno v:
De Matteis, R, Flak, M B, Gonzales-Nunez, M, Austin-Williams, S, Palmas, F, Colas, R A & Dalli, J 2022, ' Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer ', Science Advances, vol. 8, no. 5, eabl5420 . https://doi.org/10.1126/sciadv.abl5420
Inflammation is linked with carcinogenesis in many types of cancer including colorectal cancer (CRC). Aspirin is recommended for the prevention of CRC, although the mechanism(s) mediating its immunomodulatory actions remain incompletely understood. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af9cd2f19d8b770a0896c7cd72798b8
https://kclpure.kcl.ac.uk/en/publications/88bbef2b-dce5-433e-b714-fb13b4dc0c82
https://kclpure.kcl.ac.uk/en/publications/88bbef2b-dce5-433e-b714-fb13b4dc0c82
Autor:
Mathieu Benoit-Voisin, Rachael D. Wright, Asif J. Iqbal, Michele Bombardieri, Franziska Krautter, Alok Tiwari, Toshiro Niki, Mitsuomi Hirashima, Isobel A. Blacksell, Mohammed T. Hussain, Lucy V. Norling, Hannah L. Law, Gerard B. Nash, Shani Austin-Williams, Costantino Pitzalis, Dianne Cooper
Publikováno v:
The FASEB Journal. 36
Neutrophil trafficking is a key component of the inflammatory response. Here, we have investigated the role of the immunomodulatory lectin Galectin-9 (Gal-9) on neutrophil recruitment. Our data indicate that Gal-9 is upregulated in the inflamed vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0013a97d261011a607a90c9af5930a6
https://doi.org/10.1096/fj.202100832r
https://doi.org/10.1096/fj.202100832r
Publikováno v:
Free radical biologymedicine. 175
Extracellular vesicles are small membrane-derived packages of information that are released from virtually all cell types. These nano-packages contain regulatory material including proteins, lipids, mRNA and microRNA and are a key mechanism of parace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd023df277fe0605ffe132c85f6ceea4
https://pubmed.ncbi.nlm.nih.gov/34461260
https://pubmed.ncbi.nlm.nih.gov/34461260
Autor:
Lisa M. Nicholas, Michael P. Murphy, Thomas J. Ashmore, Katie L. Skeffington, Susan E. Ozanne, Megan R. Sutherland, Dino A. Giussani, Emily J. Camm, Youguo Niu, Shani Austin-Williams, Ana-Mishel Spiroski, Angela Logan
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mitochondria-derived oxidative stress during fetal development increases cardiovascular risk in adult offspring of pregnancies complicated by chronic fetal hypoxia. We investigated the efficacy of the mitochondria-targeted antioxidant MitoQ in preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42909fbb0e9dd8d64e2175e6d9b826d2
Autor:
Jose Garrido-Mesa, Dianne Cooper, Mauro Perretti, Catherine Pickworth, Matthew Golding, Tao Fu, Loïc Rolas, William A. Muller, Lucy M. Collinson, Ezra Aksoy, Maria Gonzalez-Nunez, Mathieu-Benoit Voisin, Thomas D. Nightingale, Natalia Reglero-Real, Laura Vázquez-Martínez, Shani Austin-Williams, Giulia De Rossi, Lorena Pérez-Gutiérrez, Sussan Nourshargh, Chantal M. Boulanger, Sharon A. Tooze, Yoshiaki Kubota, Anna Barkaway, Azumi Yoshimura, Rebeca S. Saleeb
Publikováno v:
Immunity
Summary The migration of neutrophils from the blood circulation to sites of infection or injury is a key immune response and requires the breaching of endothelial cells (ECs) that line the inner aspect of blood vessels. Unregulated neutrophil transen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee7732ddcf03fd2589976a2b6a36ae5
https://doi.org/10.1016/j.immuni.2021.07.012
https://doi.org/10.1016/j.immuni.2021.07.012
Autor:
Kimberly, Pistorius, Patricia R, Souza, Roberta, De Matteis, Shani, Austin-Williams, Karoline G, Primdahl, Anders, Vik, Francesca, Mazzacuva, Romain A, Colas, Raquel M, Marques, Trond V, Hansen, Jesmond, Dalli
Publikováno v:
Cell Chemical Biology
Summary Macrophages are central in orchestrating the clearance of apoptotic cells and cellular debris during inflammation, with the mechanism(s) regulating this process remaining of interest. Herein, we found that the n-3 docosapentaenoic acid-derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f319971eab1f7f9c202c7c2e5f0e6c48
https://pubmed.ncbi.nlm.nih.gov/29805036
https://pubmed.ncbi.nlm.nih.gov/29805036