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Akademický článek

Dehydrocostus lactone inhibits the proliferation and metastasis of hepatocellular carcinoma cells via modulating p53-p21-CDK2 signaling pathway

Autor: Yingying Tian, Beibei Ma, Xinyue Zhao, Shiqiu Tian, Yilin Li, Hailuan Pei, Shangyue Yu, Chuang Liu, Zhaozhou Lin, Zeping Zuo, Zhibin Wang

Publikováno v: Arabian Journal of Chemistry, Vol 16, Iss 8, Pp 104994- (2023)

Background: Hepatocellular carcinoma (HCC), a malignancy with high mortality and recurrence rates, has very limited options for treatment strategies. Dehydrocostus lactone (DL) is the principal quality marker extracted from Aucklandia lappa Decne. an

Externí odkaz: https://doaj.org/article/e821a11012fe406c9da248bc2369f2c8

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Akademický článek

Integrated Solid-Phase Extraction, Ultra-High-Performance Liquid Chromatography–Quadrupole-Orbitrap High-Resolution Mass Spectrometry, and Multidimensional Data-Mining Techniques to Unravel the Metabolic Network of Dehydrocostus Lactone in Rats

Autor: Yingying Tian, Beibei Ma, Chuang Liu, Xinyue Zhao, Shangyue Yu, Yilin Li, Shiqiu Tian, Hailuan Pei, Zijian Wang, Zeping Zuo, Zhibin Wang

Publikováno v: Molecules, Vol 27, Iss 22, p 7688 (2022)

Dehydrocostus lactone (DL) is among the representative ingredients of traditional Chinese medicine (TCM), with excellent anticancer, antibacterial, and anti-inflammatory activities. In this study, an advanced strategy based on ultra-high-performance

Externí odkaz: https://doaj.org/article/68d4b0a30d8e4523bfbcd303d890ec0c

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Akademický článek

Development of a UHPLC-MS/MS-based data-mining method for rapid profiling and characterization of magnolol metabolites in rat urine and plasma

Autor: Beibei Ma, Tianyu Lou, Tingting Wang, Ruiji Li, Jinhui Liu, Shangyue Yu, Hailuan Pei, Shiqiu Tian, Yilin Li, Yudong Guo, Zijian Wang, Zhaozhou Lin, Zhibin Wang, Jing Wang, Yingying Gao

Publikováno v: Arabian Journal of Chemistry, Vol 14, Iss 2, Pp 102954- (2021)

Magnolol, an essential bioactive natural lignans isolated from Magnolia Officinalis, has various pharmacological activities, such as antibacterial, anti-inflammatory, antioxidation and anti-tumor. In this study, a practical strategy based on ultra-hi

Externí odkaz: https://doaj.org/article/8f2ab924c99348ecacdae021f731fa7e

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