Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shangle Qi"'
Autor:
Paul E. Goss, Haiqing Hu, Lalji K. Gediya, Abhijit M. Godbole, Shangle Qi, Puranik Purushottamachar, Vincent C. O. Njar
Publikováno v:
Breast Cancer Research and Treatment. 133:137-144
VN/14-1 [4-(±)-(1H-Imidazol-1-yl)-(E)-retinoic acid], a novel retinoic acid metabolism blocking agent (RAMBA), works by inhibiting the breakdown of all-trans-retinoic acid. The purpose of this study was to evaluate the anti-tumor effects of VN/14-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b180481ec3062c9a3f11b0085c675f9
https://doi.org/10.1007/s10549-011-1724-7
https://doi.org/10.1007/s10549-011-1724-7
Publikováno v:
Breast Cancer Research and Treatment. 103:293-302
We compared the effects of atamestane (ATA) and toremifene (TOR) alone and in combination, with letrozole (LET) on bone, serum lipids and the uterus in ovariectomized (OVX) rats after 16 weeks of treatment. Compared to OVX controls lumbar vertebral a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7114ef59dc043b6fe64062c30995e264
https://doi.org/10.1007/s10549-006-9381-y
https://doi.org/10.1007/s10549-006-9381-y
Autor:
Rakesh Goel, Shangle Qi, Leonard Kaizer, Ricardo Marques, Kathrin Strasser, Ernest E. Sterns, Mark Clemons, Jean-Marc Nabholtz, Michael Crump, Amit M. Oza, Paul E. Goss, Roland De Coster, Martin E. Blackstein, Mohamed Abdolell
Publikováno v:
Breast Cancer Research and Treatment. 64:177-188
Three phase II studies were conducted to determine the efficacy and tolerability of liarozole fumarate (R85246; liarozole), a retinoic acid metabolism blocking agent (RAMBA) and aromatase inhibitor. Additionally, animal experiments in the MNU-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fd9ef6ad979aa7bfcbf9d96006cd6e
https://doi.org/10.1023/a:1006480504790
https://doi.org/10.1023/a:1006480504790
Publikováno v:
American Journal of Obstetrics and Gynecology. 182:919-925
Objective: We examined expression of messenger ribonucleic acid encoding the prostaglandin F 2α receptor in the rat myometrium throughout late gestation and its regulation by progesterone and mechanical stretch. Study Design: Normal pregnant rats we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063985fcb90931524c438cff946a225a
https://doi.org/10.1016/s0002-9378(00)70347-4
https://doi.org/10.1016/s0002-9378(00)70347-4
Publikováno v:
International Journal of Cancer. 81:104-112
Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::300d672d3239903c4fdaa2ecbade1a74
https://doi.org/10.1002/(sici)1097-0215(19990331)81:1<104::aid-ijc18>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19990331)81:1<104::aid-ijc18>3.0.co
Publikováno v:
Biology of Reproduction. 59:1055-1061
We investigated the expression of the mRNA encoding the oxytocin receptor (OTR) in rat myometrium throughout gestation and its regulation by progesterone and mechanical stretch. Using a semiquantitative reverse transcription-polymerase chain reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ed65acc75a9c13bf96c8795304256e
https://doi.org/10.1095/biolreprod59.5.1055
https://doi.org/10.1095/biolreprod59.5.1055
Autor:
Tessa Cigler, Paul E. Goss, M. E. Wood, Martin J. Yaffe, E. Nassif, Dongsheng Tu, Harriet Richardson, J. L. Pater, D. Johnston, R. L. Brunner, Shangle Qi, Carol J. Fabian, Haiqing Hu, JN Ingle
Publikováno v:
Breast cancer research and treatment. 126(2)
We hypothesized that exemestane (EXE) would reduce mammographic breast density and have unique effects on biomarkers of bone and lipid metabolism. Healthy postmenopausal women were randomized to EXE (25 mg daily) or placebo (PLAC) for 12 months and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52959b56685f4f2cb54ec3288c7356ae
https://pubmed.ncbi.nlm.nih.gov/21221773
https://pubmed.ncbi.nlm.nih.gov/21221773
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 113(3-5)
Complete estrogen blockade remains under investigation as a means to optimize anti-estrogen therapy in breast cancer thus both the efficacy and end-organ toxicities are of interest with combinations. We hypothesized that a steroidal aromatase inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c28d30aa856f9bc9fd8164ab2b91a5
https://pubmed.ncbi.nlm.nih.gov/19429427
https://pubmed.ncbi.nlm.nih.gov/19429427
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 10(17)
Purpose: Exemestane (EXE) and letrozole (LET) are third-generation aromatase inhibitors currently prescribed for postmenopausal hormone-dependent breast cancer. The impact on end organs of estrogen depletion in menopausal women is of significant clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a821c928fd5004319d72c0dbb6e952
https://pubmed.ncbi.nlm.nih.gov/15355898
https://pubmed.ncbi.nlm.nih.gov/15355898
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 92(1-2)
Our objective was to determine the effects of SCH 57068 alone and with 17 beta-estradiol (E(2)) on bone, lipids and uteri in ovariectomized (OVX) rats. In OVX animals lumbar vertebral and femoral bone mineral density (BMD) were significantly higher a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef12e0b0cc472796a9d8dd79531414ed
https://pubmed.ncbi.nlm.nih.gov/15544933
https://pubmed.ncbi.nlm.nih.gov/15544933