Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shangjiu Hu"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2781 (2022)
Aptamer–drug conjugates (ApDCs) are potential targeted pharmaceutics, but their clinical applications are hampered by fast clearance in blood. Herein we report the construction of ApDCs modified with artificial base F and the study of biological ac
Externí odkaz:
https://doaj.org/article/89da9e6a8dd94751b095cb817fa7134f
Autor:
Ling Ma, Jiajia Wen, Biao Dong, Jinming Zhou, Shangjiu Hu, Juxian Wang, Yucheng Wang, Mei Zhu, Shan Cen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14178 (2022)
With the increasing prevalence of drug-resistant variants, novel potent HIV-1 protease inhibitors with broad-spectrum antiviral activity against multidrug-resistant causative viruses are urgently needed. Herein, we designed and synthesized a new seri
Externí odkaz:
https://doaj.org/article/af68b91dc4e8436dae09fe076d8aa626
Autor:
Mei Zhu, Lei Zhou, Shangjiu Hu, Qingfang Miao, Jianhua Gong, Na Zhang, Guoning Zhang, Minghua Wang, Juxian Wang, Hongwei He, Yucheng Wang
Publikováno v:
Journal of medicinal chemistry. 65(10)
By harnessing the payload DM1 and a monoclonal antibody LR004 through a noncleavable linker succinimidyl-4-(
Autor:
Shangjiu, Hu, Ling, Ma, Biao, Dong, Qi, Shan, Jinming, Zhou, Guoning, Zhang, Minghua, Wang, Shan, Cen, Mei, Zhu, Juxian, Wang, Yucheng, Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 64:116760
Based upon the preliminary design of enhancing genetic barrier to drug-resistant viral mutants by maximizing hydrogen-bonding or other van der Waals contacts, we have designed, synthesized and biologically evaluated a new class of HIV-1 protease inhi
Autor:
Sun, Yang1 (AUTHOR), Geng, Xinyao1 (AUTHOR), Ma, Yue2 (AUTHOR), Qin, Yu1 (AUTHOR), Hu, Shangjiu1 (AUTHOR), Xie, Yuquan2 (AUTHOR) xyqah@163.com, Wang, Ruowen1 (AUTHOR) xyqah@163.com
Publikováno v:
Pharmaceutics. Dec2022, Vol. 14 Issue 12, p2781. 10p.
Autor:
Ma, Ling1 (AUTHOR), Wen, Jiajia1 (AUTHOR), Dong, Biao1 (AUTHOR), Zhou, Jinming2 (AUTHOR), Hu, Shangjiu1 (AUTHOR), Wang, Juxian1 (AUTHOR), Wang, Yucheng1 (AUTHOR), Zhu, Mei1 (AUTHOR) zhumei@imb.pumc.edu.cn, Cen, Shan1 (AUTHOR) zhumei@imb.pumc.edu.cn
Publikováno v:
International Journal of Molecular Sciences. Nov2022, Vol. 23 Issue 22, p14178. 15p.
Autor:
Scott D Mendelson
This unique volume presents new understandings of the neurochemical nature of major depression, and how herbs and their constituent flavonoids and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent st