Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Shanghui Hu"'
Autor:
Dumond Yves Rene, Junhua Tao, Liam Tully, Carlos A. Martinez, Shanghui Hu, Kelleher Patrick Gerard Thomas
Publikováno v:
Organic Process Research & Development. 12:392-398
A new manufacturing process for (S)-3-(aminomethyl)-5-methylhexanoic acid (Pregabalin), the active ingredient in Lyrica, has been developed. Using Lipolase, a commercially available lipase, rac-2-carboxyethyl-3-cyano-5-methylhexanoic acid ethyl ester
Publikováno v:
Organic Process Research & Development. 11:903-906
A new scalable enzymatic resolution approach to both enantiomers of trans-2-hydroxycyclohexanecarbonitrile (9 and 11) was developed. Treatment of the racemic mixture (4) with succinic anhydride in the presence of Novozym 435 led to selective acylatio
Autor:
Daniel R. Yazbeck, David J. Kucera, Carlos A. Martinez, Shanghui Hu, Billie J. Kline, Junhua Tao
Publikováno v:
Organic Process Research & Development. 10:650-654
(2S)-4,4-Difluoro-3,3-dimethyl-N-Boc-proline (3) is a key intermediate for the synthesis of HIV protease inhibitors. Here, several approaches for the preparation of enantiopure 3 and its analogues are disclosed. Among these methods, one strategy reli
Autor:
Curt M. Breneman, Asif Ladiwala, Kaushal Rege, Shanghui Hu, Steven M. Cramer, Jonathan S. Dordick
Publikováno v:
Journal of Chemical Information and Modeling. 45:1854-1863
We have recently developed a novel multivalent cationic library based on the derivatization of aminoglycosides by linear polyamines. In the current study, we describe the DNA-binding activity of this library. Screening results indicated that several
Publikováno v:
Tetrahedron: Asymmetry. 16:699-703
A chemoenzymatic method is described for the synthesis of a desired ketomethylene tripeptide isostere. The key step is an enzymatic hydrolysis, which removes the C-terminal ester-protecting group under mild conditions without epimerizing the existing
Publikováno v:
Journal of the American Chemical Society. 126:12306-12315
Chemoenzymatic parallel synthesis and high-throughput screening were employed to develop a multivalent aminoglycoside-polyamine library for use as high-affinity cation-exchange displacers and DNA-binding ligands. Regioselective lipase-catalyzed acyla
Publikováno v:
Advanced Synthesis & Catalysis. 345:524-532
In a pharmaceutical environment, the need for efficient and practical screening techniques has become vital in the search for ideal enzymes that can be used in the preparation of drug intermediates. This paper describes a general high throughput scre
Publikováno v:
Advanced Synthesis & Catalysis. 344:1097-1102
The selective oxidation and halogenation of nitroaromatics is a difficult task both chemically and enzymatically. We have discovered that vanadium chloroand bromoperoxidases from Curvularia inaequalis and Corralina officinalis, respectively, are capa
Publikováno v:
Tetrahedron Letters. 43:6763-6766
Enantiomerically enriched diene monoepoxides were selectively synthesized using oxidases from Pseudomonas sp. and chloroperoxidase from Caldariomyces fumago. These monoepoxides are useful monomers for generating functional chiral polymeric materials.
Autor:
Jonathan S. Dordick, Shanghui Hu
Publikováno v:
The Journal of Organic Chemistry. 67:314-317
Chloroperoxidase (CPO) catalyzes the enantioselective oxidation of cyclopropylmethanols, such as 2-methylcyclopropylmethanol, to cyclopropyl aldehydes using tert-butyl hydroperoxide as the terminal oxidant. In all cases, CPO oxidation of cis-cyclopro