Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shanghai Yu"'
Autor:
Baixi Xing, Hui Zhang, Kejun Zhang, Lekai Zhang, Xinda Wu, Xiaoying Shi, Shanghai Yu, Sanyuan Zhang
Publikováno v:
IEEE Access, Vol 7, Pp 59844-59861 (2019)
External stimulation, mood swing, and physiological arousal are closely related and induced by each other. The exploration of internal relations between these three aspects is interesting and significant. Currently, video is the most popular multimed
Externí odkaz:
https://doaj.org/article/1210dc43ccf64467a3c3a891617db919
Autor:
Peng Zou, Nan Zheng, Yanke Yu, Shanghai Yu, Wei Sun, Donna McEachem, Yongsheng Yang, Lawrence X Yu, Shaomeg Wang, Duxin Sun
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 15, Iss 2 (2012)
Purpose. The two purposes of this study were evaluating preclinical pharmacokinetics of MI-219 and predicting clearance (CL) and volume of distribution at steady-state (Vdss) of MI-219 in humans. Methods. Pharmacokinetic studies were conducted on mic
Externí odkaz:
https://doaj.org/article/d9be5453f9744a3b9c0c6e3888969ff8
Autor:
Laurent Debussche, Dimitri Gorge-Bernat, Pascal Pannier, Stéphane Guerif, Laurent Besret, Odette Dos-Santos, Angelo Aguilar, Denzil Bernard, Shanghai Yu, Sanjeev Shangary, Jianfeng Lu, Cassandra Gianna Hoffman-Luca, Liu Liu, Longchuan Bai, Jennifer L. Meagher, Jeanne A. Stuckey, Cédric Barrière, Isabelle Meaux, Donna McEachern, Yujun Zhao, Wei Sun, Shaomeng Wang
SI Table S1. Crystallography data collection and refinement statistics for the co-crystal structure of SAR405838 complexed with human MMD2 protein. SI Table S2. Binding affinities of SAR405838, as well as reference compounds to different MDM2 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10ee835201ab25b1bcd7983435e9cfe
https://doi.org/10.1158/0008-5472.22403966
https://doi.org/10.1158/0008-5472.22403966
Autor:
Xinda Wu, Shanghai Yu, Baixi Xing, Lekai Zhang, Hui Zhang, Kejun Zhang, Sanyuan Zhang, Xiaoying Shi
Publikováno v:
IEEE Access, Vol 7, Pp 59844-59861 (2019)
External stimulation, mood swing, and physiological arousal are closely related and induced by each other. The exploration of internal relations between these three aspects is interesting and significant. Currently, video is the most popular multimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ac6e93d67a99e566588e18a5223fdb
https://doi.org/10.1109/access.2019.2914872
https://doi.org/10.1109/access.2019.2914872
Autor:
Shaomeng Wang, Laurent Besret, Shanghai Yu, Isabelle Meaux, Jennifer L. Meagher, Angelo Aguilar, Yujun Zhao, Donna McEachern, Cedric Barriere, Denzil Bernard, Jianfeng Lu, Laurent Debussche, Wei Sun, Cassandra Gianna Hoffman-Luca, Longchuan Bai, Jeanne A. Stuckey, Sanjeev Shangary, Stephane Guerif, Liu Liu, Dimitri Gorge-Bernat, Odette Dos-Santos, Pascal Pannier
Publikováno v:
Cancer Research. 74:5855-5865
Blocking the oncoprotein murine double minute 2 (MDM2)–p53 protein–protein interaction has long been considered to offer a broad cancer therapeutic strategy, despite the potential risks of selecting tumors harboring p53 mutations that escape MDM2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a3050e57a4675fc7db9fd95e4e4907
https://doi.org/10.1158/0008-5472.can-14-0799
https://doi.org/10.1158/0008-5472.can-14-0799
Autor:
Duxin Sun, Sanjeev Shargary, Jianfeng Lu, Shaomeng Wang, Liu Liu, Donna McEachern, Wei Sun, Shanghai Yu, Peng Zou, Ting Zhao, Denzil Bernard, Yujun Zhao, Xiaoqin Li
Publikováno v:
Journal of Medicinal Chemistry. 56:5553-5561
We previously reported the discovery of a class of spirooxindoles as potent and selective small-molecule inhibitors of the MDM2-p53 interaction (MDM2 inhibitors). We report herein our efforts to improve their pharmacokinetic properties and in vivo an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0391868987194d96b7fdf52489b5a44c
https://doi.org/10.1021/jm4005708
https://doi.org/10.1021/jm4005708
Autor:
Guoping Wang, Donna McEachern, Dongguang Qin, Shaomeng Wang, Sanjeev Shangary, Jianyong Chen, Sanmao Kang, Zaneta Nikolovska-Coleska, Ke Ding, Dajun Yang, Su Qiu, Rebecca Miller, Shanghai Yu
Publikováno v:
Journal of Medicinal Chemistry. 52:7970-7973
We report herein the design of potent and orally active small-molecule inhibitors of the MDM2-p53 interaction. Compound 5 binds to MDM2 with a Ki value of 0.6 nM, activates p53 at concentrations as low as 40 nM, and potently and selectively inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e0aa71ecf9b301e0e9b364fe56ef09
https://doi.org/10.1021/jm901400z
https://doi.org/10.1021/jm901400z
Autor:
Ben Li, Dawei Ma, Xing He, Miao Wang, Jonathan Coates, Eric Dale Jones, Xin Xie, David Ian Rhodes, Enkun Zhou, Li Chen, John Deadman, Shanghai Yu, Gang Pei, Dean Baylis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5334-5336
Modification of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists revealed that introducing a fluoro group at the 3-position of the 3-phenyl group to reduce metabolism did not adversely affect the high potency against HIV infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71435a24101c456492827fa0df69d047
https://doi.org/10.1016/j.bmcl.2010.05.046
https://doi.org/10.1016/j.bmcl.2010.05.046
Autor:
John Deadman, Xing He, Enkun Zhou, Dawei Ma, Shanghai Yu, Miao Wang, Eric Dale Jones, Chen Li, Xin Xie, David Ian Rhodes, Dean Baylis, Jonathan Coates, Li Ben, Gang Pei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4012-4014
A novel series of CCR5 antagonists has been identified, utilizing the lead, nifeviroc, which were further modified based on bioisosteric principles. Lead optimization was pursued by balancing potential toxicity and potency. Potent analogues with low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f8889a4ebbffe4fda697ce897f1d4c
https://doi.org/10.1016/j.bmcl.2010.05.102
https://doi.org/10.1016/j.bmcl.2010.05.102
Autor:
Liu Liu, Jeffrey R. Deschamps, Jianfeng Lu, Denzil Bernard, Shanghai Yu, Yujun Zhao, Duxin Sun, Xiaoqin Li, Donna McEachern, Jean Christophe Carry, Philippe Ochsenbein, Shaomeng Wang, Wei Sun, Vincent Ferey
Publikováno v:
Journal of the American Chemical Society. 135(19)
Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e325c795354f53cc55139c42fbd5b7c1
https://pubmed.ncbi.nlm.nih.gov/23641733
https://pubmed.ncbi.nlm.nih.gov/23641733