Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Shang-Ying P. King"'
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Autor: Irma H. Benedek, Henry J. Pieniaszek, Mark A. Joslin, Karen Raudibaugh, Shang-Ying P. King
Publikováno v: Pharmaceutical Research. 12:1874-1877
Purpose. To examine the pharmacokinetics of warfarin after administration of single oral doses (2, 5, and 10 mg) to healthy male volunteers.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bb35ec1f8590d6ab3bb5bbc14399bd5
https://doi.org/10.1023/a:1016223418652
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2
Protein binding of brequinar in the plasma of healthy donors and cancer patients and analysis of the relationship between protein binding and pharmacokinetics in cancer patients
Autor: Allison M. Agra, Joseph R. Bertino, Check Y. Quon, Huey-Shin L. Shen, Henry J. Pieniaszek, Violante Currie, Shang-Ying P. King, Cecilia L. Chi, David B. Adams
Publikováno v: Cancer Chemotherapy and Pharmacology. 35:101-108
The protein binding of weakly acidic and basic drugs has been shown to be altered in cancer patients. Brequinar is a weakly acidic, low-clearance, and highly protein-bound (> 98% bound) antitumor agent. The pharmacokinetic parameters of brequinar are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea5956ac43646a5185847a0d48097b1
https://doi.org/10.1007/bf00686630
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3
Effect of Moricizine on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Volunteers
Autor: Irma H. Benedek, Allison M. Agra, Shang-Ying P. King, William L. Schary, Henry J. Pieniaszek, Richard J. Powell
Publikováno v: The Journal of Clinical Pharmacology. 32:558-563
Moricizine HCl, a new orally active antiarrhythmic agent, induces its own hepatic metabolism and consequently may interfere with the metabolism of warfarin, a drug used commonly by cardiac patients that also is subject to extensive hepatic metabolism
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a515d465dd0c683ee987f112eff2948
https://doi.org/10.1177/009127009203200612
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4
Degradation Kinetics and Mechanisms of Moricizine Hydrochloride in Acidic Medium
Autor: J. Dudzinski, Shang-Ying P. King, George Torosian, Kenneth W. Sigvardson
Publikováno v: Journal of Pharmaceutical Sciences. 81:586-591
The degradation kinetics of moricizine hydrochloride (1) were examined over a pH range of 0.6 to 6.0 at an ionic strength of 0.3 and 60 degrees C. The disappearance of intact 1 was followed by a stability-indicating HPLC assay. The degradation produc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227e7075b79dc8bb090b742b78cb08d9
https://doi.org/10.1002/jps.2600810625
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5
Phase I safety and pharmacokinetic studies of brequinar sodium after single ascending oral doses in stable renal, hepatic, and cardiac allograft recipients
Autor: Alan H. Menkis, Brigitte Schaefle, Leonard Makowka, Amita Joshi, Barbara A. Zajac, Shang-Ying P. King, Calvin R. Stiller, Linda Sher, David M. Kornhauser, Barry D. Kahan
Publikováno v: Journal of clinical pharmacology. 37(12)
Brequinar sodium (BQR), a substituted 4-quinoline carboxylic acid, was in clinical development in combination with cyclosporine (CsA) as a potentially effective therapy for the treatment and prophylaxis of rejection in organ transplant patients. This
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7c93b2ebaefa365b0e7afd3318eb48
https://pubmed.ncbi.nlm.nih.gov/9506007
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6
Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers
Autor: Irma H. Benedek, Henry J. Pieniaszek, Shang‐Ying P. King, Amita Joshi, David M. Kornhauser
Publikováno v: Journal of clinical pharmacology. 35(12)
Data describing the pharmacokinetics and pharmacodynamics of low dose aspirin (acetylsalicylic acid; ASA) are limited. This single-center study was designed to determine the rate and extent of oral absorption of 80-mg ASA tablets in healthy, young ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16faa4e60f9de10907796b1092324d0
https://pubmed.ncbi.nlm.nih.gov/8750369
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7
Simultaneous quantification of an anti-inflammatory compound (DuP 697) and a potential metabolite (X6882) in human plasma and urine by high-performance liquid chromatography
Autor: Amita S. Joshi, Kiyokazu Takahashi, Nirmala Raghavan, Heizo Shingu, Robert M. Williams, Shang-Ying P. King
Publikováno v: Journal of chromatography. B, Biomedical applications. 660(1)
A high-performance liquid chromatographic (HPLC) method using fluorescence detection has been developed for the simultaneous analysis of low nanogram concentrations of an anti-inflammatory drug, 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a26d86efda2d6771406e3be087c0f9e
https://pubmed.ncbi.nlm.nih.gov/7858707
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9
Nanogram level quantitation of oxycodone in human plasma by capillary gas chromatography using nitrogen-phosphorus selective detection
Autor: Patricia K. Padovani, Gilbert N. Lam, Shang-Ying P. King, Ram Kapil
Publikováno v: Journal of chromatography. 577(2)
A sensitive and specific capillary gas chromatographic assay is reported for the quantitation of oxycodone in human plasma. The technique involves a single extraction of oxycodone and internal standard (hydrocodone) from plasma by toluene containing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d322815274f71516f2ddc1720e36a1
https://pubmed.ncbi.nlm.nih.gov/1400759
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10
Examination of the in vitro degradation of [14C]pentaerythritol tetranitrate in rat and human blood with an improved thin-layer radiochromatographic procedure
Autor: Shang-Ying P. King, Ho-Leung Fung
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 343:129-137
Improvements were made on a reported thin-layer radiochromatographic assay for the determination of [14C] pentaerythritol tetranitrate (PETN) and its metabolites in whole blood, using methanol instead of dioxane as the extracting solvent. Recovery of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9631cd819562c1b254d7b2499c04b9f9
https://doi.org/10.1016/s0378-4347(00)84575-2
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