Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Shang‐Lang Huang"'
Publikováno v:
Cancer Science. 113:2616-2626
More than 90% of ovarian cancer deaths are due to relapse following development of chemoresistance. Our main objective is to better understand the molecular mechanism underlying paclitaxel resistance (taxol resistance, Txr) in ovarian cancer. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326732dccde64dca2f8ee34ce2eea2db
https://doi.org/10.1111/cas.15448
https://doi.org/10.1111/cas.15448
Publikováno v:
Biochemical Pharmacology. 212:115581
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7c6ec8081bbc079b88159cd3a53c947
https://doi.org/10.1016/j.bcp.2023.115581
https://doi.org/10.1016/j.bcp.2023.115581
Publikováno v:
Biochemical pharmacology. 177
Toll-like receptor 4 (TLR4) is often overexpressed in taxol-resistant cancer cells. Here we used whole-genome transcriptomic analysis to identify 787 upregulated genes in SKOV3 ovarian carcinoma cells that ectopically express TLR4. Using chromatin im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41abb6179fb6ffdb3f1c50eef0772cfc
https://pubmed.ncbi.nlm.nih.gov/32278794
https://pubmed.ncbi.nlm.nih.gov/32278794
Publikováno v:
Journal of Cellular Physiology. 233:2489-2501
We report here that toll-like receptor 4 (TLR4) and ABCB1 are upregulated in SKOV3 ovarian carcinoma cells that acquired resistance to the anticancer drug taxol. Silencing of TLR4 using short-hairpin RNA sensitized taxol-resistant SKOV3 cells to taxo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605743a4dd25613f19e02bba6b18b932
https://doi.org/10.1002/jcp.26125
https://doi.org/10.1002/jcp.26125
Publikováno v:
Biochemical Pharmacology. 186:114456
Ovarian cancer is poorly treatable due, at least in part, to induced drug resistance to taxol- and cisplatin-based chemotherapy. Recent studies showed that ectopic overexpression of toll-like receptor 4 (TLR4) in ovarian cancer cells leads to upregul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2adbb596ac193817002c8383cd8046
https://doi.org/10.1016/j.bcp.2021.114456
https://doi.org/10.1016/j.bcp.2021.114456
Publikováno v:
Journal of cellular physiology. 234(6)
We report here that the androgen receptor (AR) and ABCB1 are upregulated in a model of acquired taxol resistance (txr) in ovarian carcinoma cells. AR silencing sensitizes txr cells to taxol threefold, whereas ectopic AR expression in AR-null HEK293 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e43b5440efda3cd65ecf5d007ed58a
https://pubmed.ncbi.nlm.nih.gov/30317630
https://pubmed.ncbi.nlm.nih.gov/30317630
Publikováno v:
Oncotarget
A systematic analysis of the genes involved in taxol resistance (txr) has never been performed. In the present study, we created txr ovarian carcinoma cell lines to identify the genes involved in chemoresistance. Transcriptome analysis revealed 1,194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f168539fdb3399177f1d82c7a3569b0c
https://doi.org/10.18632/oncotarget.4824
https://doi.org/10.18632/oncotarget.4824
Autor:
Shang-Lang Huang, Chuck C.-K. Chao
Publikováno v:
Cancers; Volume 7; Issue 2; Pages: 1052-1071
Cancers, Vol 7, Iss 2, Pp 1052-1071 (2015)
Cancers
Volume 7
Issue 2
Pages 1052-1071
Cancers, Vol 7, Iss 2, Pp 1052-1071 (2015)
Cancers
Volume 7
Issue 2
Pages 1052-1071
A previous genome-wide screening analysis identified a panel of genes that sensitize the human non-small-cell lung carcinoma cell line NCI-H1155 to taxol. However, whether the identified genes sensitize other cancer cells to taxol has not been examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b21986fe3e2ac18b691f5ca78fcc0bb
https://doi.org/10.3390/cancers7020824
https://doi.org/10.3390/cancers7020824
Publikováno v:
Oncotarget
Taxol is a mitotoxin widely used to treat human cancers, including of the breast and ovary. However, taxol resistance (txr) limits treatment efficacy in human patients. To study chemoresistance in ovarian cancer, we established txr ovarian carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c25fbc368b6c107e3b5f2367f3e913
https://doi.org/10.18632/oncotarget.2654
https://doi.org/10.18632/oncotarget.2654
Publikováno v:
Biochemical Journal. 444:303-314
In the present study, we observed that the Golgi-SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) GS28 forms a complex with p53 in HEK (human embryonic kidney)-293 cells. Given that p53 represents a tumour suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2d894f39ecf8a4fe5c3f70a4a8c3f2
https://doi.org/10.1042/bj20112223
https://doi.org/10.1042/bj20112223