Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Shane W. O'Brien"'
Autor:
Harvey H. Hensley, Navid A. Roder, Shane W. O'Brien, Laura E. Bickel, Fang Xiao, Sam Litwin, Denise C. Connolly
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 6, Pp 451-462 (2012)
Most patients with epithelial ovarian cancer (EOC) experience drug-resistant disease recurrence. Identification of new treatments is a high priority, and preclinical studies in mouse models of EOC may expedite this goal. We previously developed metho
Externí odkaz:
https://doaj.org/article/5b2fce15bd0a4249a2cbf946d6d1ce4a
Supplemental Table 2 from Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth
Autor:
Denise C. Connolly, Dennis Huszar, Luis J. Sigal, Siddharth Balachandran, Samuel Litwin, Emmanuelle Nicolas, Yan Zhou, Roshan J. Thapa, Ren-Huan Xu, Marisa A. Maglaty, Rashid Gabbasov, Shane W. O'Brien, Fang Xiao, Galina Gritsina
Supplemental Table 2. Gene ontology (GO) enrichment categories.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c45f83e7f9e490547eb98f1d08e080
https://doi.org/10.1158/1535-7163.22501363.v1
https://doi.org/10.1158/1535-7163.22501363.v1
Supplemental Table 1 from Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth
Autor:
Denise C. Connolly, Dennis Huszar, Luis J. Sigal, Siddharth Balachandran, Samuel Litwin, Emmanuelle Nicolas, Yan Zhou, Roshan J. Thapa, Ren-Huan Xu, Marisa A. Maglaty, Rashid Gabbasov, Shane W. O'Brien, Fang Xiao, Galina Gritsina
Supplemental Table 1. Differentially expressed genes in AZD1480 treated tumors vs. vehicle treated controls (2-fold change and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fd190bd505cad65372ef2f49c5cbc6
https://doi.org/10.1158/1535-7163.22501366
https://doi.org/10.1158/1535-7163.22501366
Autor:
Denise C. Connolly, Dennis Huszar, Luis J. Sigal, Siddharth Balachandran, Samuel Litwin, Emmanuelle Nicolas, Yan Zhou, Roshan J. Thapa, Ren-Huan Xu, Marisa A. Maglaty, Rashid Gabbasov, Shane W. O'Brien, Fang Xiao, Galina Gritsina
Supplementary Figures S1-S3: Supplementary Figure S1. AZD1480 abrogates STAT3 DNA binding while targeting JAK2 or STAT3 has little effect on viability or proliferation in cultured cells. Supplementary Figure S2. Pharmacodynamics of AZD1480 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5d78b8cc94840a88c4b0ae3d7e13bd
https://doi.org/10.1158/1535-7163.22501360
https://doi.org/10.1158/1535-7163.22501360
Autor:
Denise C. Connolly, Dennis Huszar, Luis J. Sigal, Siddharth Balachandran, Samuel Litwin, Emmanuelle Nicolas, Yan Zhou, Roshan J. Thapa, Ren-Huan Xu, Marisa A. Maglaty, Rashid Gabbasov, Shane W. O'Brien, Fang Xiao, Galina Gritsina
Ovarian carcinoma is the fifth leading cause of death among women in the United States. Persistent activation of STAT3 is frequently detected in ovarian carcinoma. STAT3 is activated by Janus family kinases (JAK) via cytokine receptors, growth factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3259b200005ffd8f4d2277fdb1daf5b0
https://doi.org/10.1158/1535-7163.c.6536764.v1
https://doi.org/10.1158/1535-7163.c.6536764.v1
Autor:
Denise C. Connolly, Erica A. Golemis, David A. Proia, Lainie P. Martin, Samuel Litwin, Igor Astsaturov, Marisa A. Maglaty, Shane W. O'Brien, Ilya G. Serebriiskii, Fang Xiao, Hanqing Liu
Purpose: Epithelial ovarian cancer (EOC) is usually detected at an advanced stage and is frequently lethal. Although many patients respond to initial surgery and standard chemotherapy consisting of a platinum-based agent and a taxane, most experience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4522f671c6fc9eb7dbc2d9070c0664ba
https://doi.org/10.1158/1078-0432.c.6522231.v1
https://doi.org/10.1158/1078-0432.c.6522231.v1
Autor:
Denise C. Connolly, Erica A. Golemis, David A. Proia, Lainie P. Martin, Samuel Litwin, Igor Astsaturov, Marisa A. Maglaty, Shane W. O'Brien, Ilya G. Serebriiskii, Fang Xiao, Hanqing Liu
XLSX file - 22KB, Table of 130 proteins in expanded sensitization network with reported drug inhibitors, based on data reported in DrugBank and Ingenuity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bbfc6f844e4815f397c3a8637a5182
https://doi.org/10.1158/1078-0432.22451616.v1
https://doi.org/10.1158/1078-0432.22451616.v1
Autor:
Denise C. Connolly, Erica A. Golemis, David A. Proia, Lainie P. Martin, Samuel Litwin, Igor Astsaturov, Marisa A. Maglaty, Shane W. O'Brien, Ilya G. Serebriiskii, Fang Xiao, Hanqing Liu
PDF file - 78KB, Drug sensitization summary for HCT116 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab7a28b5c3c289ab8aa1d35d80ed2a0
https://doi.org/10.1158/1078-0432.22451640.v1
https://doi.org/10.1158/1078-0432.22451640.v1
Autor:
Neil Johnson, Violeta Serra, Judith Balmaña, Jos Jonkers, Peter Bouwman, Elizabeth M. Swisher, Mary B. Daly, Denise C. Connolly, David L. Wiest, Geoffrey I. Shapiro, Alan D. D'Andrea, Susanne K. Kjaer, Simon A. Gayther, Siegal Sadetzki, Robert Nussbaum, Martin Gore, Mark H. Greene, Javier J. Benitez, Håkan Olsson, Georgia Chenevix-Trench, Diether Lambrechts, Charlie Gourley, Beth Karlan, Paul D. P. Pharoah, Francisco J. Candido Dos Reis, Shawn F. Johnson, Maribel I. Harrell, Yong Zhang, Shane W. O'Brien, Ingrid van der Heijden, Hanneke van der Gulden, Suraj Peri, Emmanuelle Nicolas, Joseph Nacson, John J. Krais, Cristina Cruz, Andrea J. Bernhardy, Yifan Wang
Genetic analyses of BRCA1 mutant cell lines and PDX models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1306d571654484b54d287ed4865812c0
https://doi.org/10.1158/0008-5472.22412754
https://doi.org/10.1158/0008-5472.22412754
Autor:
Neil Johnson, Violeta Serra, Judith Balmaña, Jos Jonkers, Peter Bouwman, Elizabeth M. Swisher, Mary B. Daly, Denise C. Connolly, David L. Wiest, Geoffrey I. Shapiro, Alan D. D'Andrea, Susanne K. Kjaer, Simon A. Gayther, Siegal Sadetzki, Robert Nussbaum, Martin Gore, Mark H. Greene, Javier J. Benitez, Håkan Olsson, Georgia Chenevix-Trench, Diether Lambrechts, Charlie Gourley, Beth Karlan, Paul D. P. Pharoah, Francisco J. Candido Dos Reis, Shawn F. Johnson, Maribel I. Harrell, Yong Zhang, Shane W. O'Brien, Ingrid van der Heijden, Hanneke van der Gulden, Suraj Peri, Emmanuelle Nicolas, Joseph Nacson, John J. Krais, Cristina Cruz, Andrea J. Bernhardy, Yifan Wang
Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8523eb61f89b8abdcf650373af811045
https://doi.org/10.1158/0008-5472.c.6508503.v1
https://doi.org/10.1158/0008-5472.c.6508503.v1