Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shane T. Grosser"'
Autor:
Christopher K. Prier, Karla Camacho Soto, Jacob H. Forstater, Nadine Kuhl, Jeffrey T. Kuethe, Wai Ling Cheung-Lee, Michael J. Di Maso, Claire M. Eberle, Shane T. Grosser, Hsing-I Ho, Erik Hoyt, Anne Maguire, Kevin M. Maloney, Amanda Makarewicz, Jonathan P. McMullen, Jeffrey C. Moore, Grant S. Murphy, Karthik Narsimhan, Weilan Pan, Nelo R. Rivera, Anumita Saha-Shah, David A. Thaisrivongs, Deeptak Verma, Adeya Wyatt, Daniel Zewge
Publikováno v:
ACS Catalysis. :7707-7714
Enzymes are capable of unique and selective transformations that can enable sustainable chemical production. While many industrial processes have been developed using free enzymes in aqueous solutions, immobilizing enzymes on a solid support can offe
Autor:
Edward C. Sherer, Junyong Jo, Holst M. Halsey, Jack Liang, Niki R. Patel, Agustina Rodriguez-Granillo, Christopher C. Nawrat, Aaron M. Whittaker, Canada Keith A, Margie Borra-Garske, Nicholas M. Marshall, Kevin R. Campos, Anna Fryszkowska, Yingju Xu, Paul N. Devine, Shane T. Grosser, Grant S. Murphy, Jovana Nazor, Matthew D. Truppo, Benjamin F. Mann, Jeffrey C. Moore, Sandra A. Robaire, Gregory Hughes, Scott J. Novick, Da Duan, Jacob Forstater, Joshua N. Kolev, Deeptak Verma, Kevin M. Maloney, Oscar Alvizo, Mark A. Huffman, Li Xiao, Mark McLaughlin, Leo A. Joyce, Hao Yang
Publikováno v:
Science. 366:1255-1259
Maximal efficiency from enzyme cascades Enzymes are highly selective catalysts that can be useful for specific transformations in organic synthesis. Huffman et al. combined designer enzymes in a multistep cascade reaction (see the Perspective by O'Re
Autor:
Shane T. Grosser, Kevin H. Stone, Jonathan P. McMullen, Lu Han, Christos Georgakis, Joel M. Hawkins, Yachao Dong, Ke Wang, Jason Mustakis
Publikováno v:
Industrial & Engineering Chemistry Research. 58:13611-13621
The Dynamic Response Surface Methodology (DRSM; Klebanov, N.; Georgakis, C. Ind. Eng. Chem. Res 2016, 55, 4022) is a data-driven modeling methodology for time-resolved measurements from Design of Experiments data sets. To extend its use to semi-infin
Autor:
John R. Naber, Shane T. Grosser, Kerstin Zawatzky, Jinchu Liu, Jon A. Jurica, Folarin Adedeji, Yining Ji, Melodie Christensen, Jason E. Hein
Publikováno v:
Reaction Chemistry & Engineering. 4:1555-1558
Automated kinetic profiling is a valuable tool for providing insights into key mechanistic features of complex catalytic systems. In an attempt to optimize a palladium-catalyzed Suzuki cross-coupling reaction, automated kinetic profiling was utilized
Publikováno v:
Reaction Chemistry & Engineering. 4:1637-1645
Continuous flow processing continues to garner interest in the pharmaceutical industry for the production of small-molecule drug substances given the advantages associated with improved mass and heat transfer, more facile scale-up, and smaller proces
Autor:
Shane T. Grosser, Timothy Rhodes, Madhumitha Balasubramanian, Melinda Liu, Karl S. Booksh, Jacob Forstater, Mackenzie L. Lauro, Joseph P. Smith, Xiaodong Bu, Zachary E. X. Dance
Publikováno v:
The Analyst. 145(23)
Directed enzyme evolution has led to significant application of biocatalysis for improved chemical transformations throughout the scientific and industrial communities. Biocatalytic reactions utilizing evolved enzymes immobilized within microporous s
Publikováno v:
Tetrahedron. 73:5048-5053
Direct MISER (Multiple Injections in a Single Experimental Run) chromatographic analysis can afford easy to interpret kinetic profiles of chemical reactions without the need for peak integration, data input or graphing. Several examples are presented
Autor:
Ke Wang, Yachao Dong, Kevin H. Stone, Joel M. Hawkins, Jason Mustakis, Jonathan P. McMullen, Shane T. Grosser, Christos Georgakis, Lu Han
Publikováno v:
AIChE Journal. 65
Autor:
Shane T. Grosser, Angela Spartalis, John Higgins, George Zhou, Gabriel C. Graffius, Cindy Starbuck, Busolo Wabuyele, Aaron Moment, Paul Fernandez, Lei Sun, Ganeshwar Prasad
Publikováno v:
Organic Process Research & Development. 20:653-660
The transamination-chemistry-based process for sitagliptin is a through-process, which challenges the crystallization of the active pharmaceutical ingredient (API) in a batch stream composed of multiple components. Risk-assessment-based design of exp
Publikováno v:
Analytical chemistry. 87(22)
We demonstrate that the use of wormlike nonionic micelles as drag-tags in end-labeled free-solution electrophoresis ("micelle-ELFSE") provides single-base resolution of Sanger sequencing products up to 502 bases in length, a nearly 2-fold improvement