Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shane Rui Zhao"'
Publikováno v:
Stem Cell Research, Vol 74, Iss , Pp 103272- (2024)
South Asians, which represent around 25% of the world’s population, have a disproportionately high risk of cardiometabolic disease, two-fold higher risk of myocardial infarction, and 4- to 6-fold higher risk for diabetes compared to Caucasians. We
Externí odkaz:
https://doaj.org/article/4b8f1f881dee4e568fbd1dca7cf68956
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102256- (2023)
Summary: Cardiac pericytes are a critical yet enigmatic cell type within the coronary microvasculature. Since primary human cardiac pericytes are not readily accessible, we present a protocol to generate them from human induced pluripotent stem cells
Externí odkaz:
https://doaj.org/article/850cfbfae60541b2bf11d06545514ade
Autor:
Tina Tianbo Zhang, Shane Rui Zhao, Christina Alamana, Mengcheng Shen, Victoria Parikh, Matthew T. Wheeler, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102941- (2022)
Dilated cardiomyopathy (DCM) is a common heart disease that can lead to heart failure and sudden cardiac death. Mutations in the TTN gene are the most frequent cause of DCM. Here, we generated two human induced pluripotent stem cell (iPSC) lines from
Externí odkaz:
https://doaj.org/article/f8723fa1a65b4bbbb48c21b9e454ddf6
Autor:
Shane Rui Zhao, Mengcheng Shen, Chelsea Lee, Yanjun Zha, Julio V. Guevara, Matthew T. Wheeler, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 57, Iss , Pp 102597- (2021)
Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with a prevalence of about 0.2%. HCM is typically caused by mutations in genes encoding sarcomere or sarcomere-associated proteins. Here, we characterized induced pluripotent stem
Externí odkaz:
https://doaj.org/article/0950bb3b3c6e40cfbdf78fc8d624010c
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100859- (2021)
Summary: Multiple strategies have been developed to efficiently differentiate human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Here, we describe a protocol for measuring three key functional parameters of hiPSC-CMs, including c
Externí odkaz:
https://doaj.org/article/60bfd3d12128435f955f55e4666a200e
SGLT2i ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant
Autor:
Hongchao Guo, Xuan Yu, Yu Liu, David T. Paik, Johanne Marie Justesen, Mark Chandy, James W. S. Jahng, Tiejun Zhang, Weijun Wu, Freeborn Rwere, Shane Rui Zhao, Suman Pokhrel, Rabindra V. Shivnaraine, Souhrid Mukherjee, Daniel J. Simon, Amit Manhas, Angela Zhang, Che-Hong Chen, Manuel A. Rivas, Eric R. Gross, Daria Mochly-Rosen, Joseph C. Wu
Publikováno v:
Sci Transl Med
The common aldehyde dehydrogenase 2 ( ALDH2 ) alcohol flushing variant known as ALDH2*2 affects ∼8% of the world’s population. Even in heterozygous carriers, this missense variant leads to a severe loss of ALDH2 enzymatic activity and has been li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab12464782ca2f9f61fc482c41282e45
https://europepmc.org/articles/PMC10297796/
https://europepmc.org/articles/PMC10297796/
Publikováno v:
J Vis Exp
Drug-induced cardiotoxicity is the leading cause of drug attrition and withdrawal from the market. Therefore, using appropriate preclinical cardiac safety assessment models is a critical step during drug development. Currently, cardiac safety assessm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1127a3796e91e5e9a48eb8d3df406f39
https://pubmed.ncbi.nlm.nih.gov/35993757
https://pubmed.ncbi.nlm.nih.gov/35993757
Publikováno v:
Current cardiology reportsPapers of particular interest, published recently, have been highlighted as:• Of importance•• Of major importance. 24(5)
Induced pluripotent stem cells (iPSCs) have become widely adopted tools in cardiovascular biology due to their ability to differentiate into patient-specific cell types. Here, we describe the current protocols, important discoveries, and experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c179ab0ac873163e95d61187ac70fc59
https://pubmed.ncbi.nlm.nih.gov/35244869
https://pubmed.ncbi.nlm.nih.gov/35244869
Autor:
Suet Nee Chen, Chi Keung Lam, Ying-Wooi Wan, Shanshan Gao, Olfat A. Malak, Shane Rui Zhao, Raffaella Lombardi, Amrut V. Ambardekar, Michael R. Bristow, Joseph Cleveland, Marta Gigli, Gianfranco Sinagra, Sharon Graw, Matthew R.G. Taylor, Joseph C. Wu, Luisa Mestroni
FLNC truncating mutations ( FLNCtv ) are prevalent causes of inherited dilated cardiomyopathy (DCM), with a high risk of developing arrhythmogenic cardiomyopathy. We investigated the molecular mechanisms of mutant FLNC in the pathogenesis of arrhythm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb55d6b6c8f39d04b9d64a2771d90bd5
https://www.science.org/doi/10.1126/sciadv.abk0052
https://www.science.org/doi/10.1126/sciadv.abk0052
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 4, Pp 100859-(2021)
STAR Protocols, Vol 2, Iss 4, Pp 100859-(2021)
Summary Multiple strategies have been developed to efficiently differentiate human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Here, we describe a protocol for measuring three key functional parameters of hiPSC-CMs, including co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbce72515e1e8adbdb0820fa570539a
http://europepmc.org/articles/PMC8551496
http://europepmc.org/articles/PMC8551496