Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shane R Horman"'
Autor:
Jeremy To, Doug Quackenbush, Emily Rowell, Lilin Li, Connor Reed, Frederick Lo, Shane R. Horman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jeremy To et al. develop an ultra-high-content assay platform used to interrogate T-cell-mediated killing of 3D multicellular tumor spheroids. They screen 1,800 annotated compounds to identify small molecules that enhance cytotoxic CD8+ T-cell activi
Externí odkaz:
https://doaj.org/article/a2fe4f359c6846cb9abcd2c93d669558
Autor:
Jeremy To, Doug Quackenbush, Emily Rowell, Lilin Li, Connor Reed, Frederick Lo, Shane R. Horman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/810912beabae49e5ae801ee19704df74
Autor:
Srinivas Niranj Chandrasekaran, Jeanelle Ackerman, Eric Alix, D. Michael Ando, John Arevalo, Melissa Bennion, Nicolas Boisseau, Adriana Borowa, Justin D. Boyd, Laurent Brino, Patrick J. Byrne, Hugo Ceulemans, Carolyn Ch’ng, Beth A. Cimini, Djork-Arne Clevert, Nicole Deflaux, John G Doench, Thierry Dorval, Regis Doyonnas, Vincenza Dragone, Ola Engkvist, Patrick W. Faloon, Briana Fritchman, Florian Fuchs, Sakshi Garg, Tamara J. Gilbert, David Glazer, David Gnutt, Amy Goodale, Jeremy Grignard, Judith Guenther, Yu Han, Zahra Hanifehlou, Santosh Hariharan, Desiree Hernandez, Shane R Horman, Gisela Hormel, Michael Huntley, Ilknur Icke, Makiyo Iida, Christina B. Jacob, Steffen Jaensch, Jawahar Khetan, Maria Kost-Alimova, Tomasz Krawiec, Daniel Kuhn, Charles-Hugues Lardeau, Amanda Lembke, Francis Lin, Kevin D. Little, Kenneth R. Lofstrom, Sofia Lotfi, David J. Logan, Yi Luo, Franck Madoux, Paula A. Marin Zapata, Brittany A. Marion, Glynn Martin, Nicola Jane McCarthy, Lewis Mervin, Lisa Miller, Haseeb Mohamed, Tiziana Monteverde, Elizabeth Mouchet, Barbara Nicke, Arnaud Ogier, Anne-Laure Ong, Marc Osterland, Magdalena Otrocka, Pieter J. Peeters, James Pilling, Stefan Prechtl, Chen Qian, Krzysztof Rataj, David E Root, Sylvie K. Sakata, Simon Scrace, Hajime Shimizu, David Simon, Peter Sommer, Craig Spruiell, Iffat Sumia, Susanne E Swalley, Hiroki Terauchi, Amandine Thibaudeau, Amy Unruh, Jelle Van de Waeter, Michiel Van Dyck, Carlo van Staden, Michał Warchoł, Erin Weisbart, Amélie Weiss, Nicolas Wiest-Daessle, Guy Williams, Shan Yu, Bolek Zapiec, Marek Żyła, Shantanu Singh, Anne E. Carpenter
Image-based profiling has emerged as a powerful technology for various steps in basic biological and pharmaceutical discovery, but the community has lacked a large, public reference set of data from chemical and genetic perturbations. Here we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad294298f87b0d35776a491fba28d7f
https://doi.org/10.1101/2023.03.23.534023
https://doi.org/10.1101/2023.03.23.534023
Autor:
Shan Yu, Matthew Ericson, Andrea Fanjul, Derek M. Erion, Maria Paraskevopoulou, Erin N. Smith, Banumathi Cole, Ryan Feaver, Corine Holub, Narender Gavva, Shane R. Horman, Jie Huang
Publikováno v:
ACS Chemical Biology. 17:918-929
Liver fibrosis progression in chronic liver disease leads to cirrhosis, liver failure, or hepatocellular carcinoma and often ends in liver transplantation. Even with an increased understanding of liver fibrogenesis and many attempts to generate thera
Autor:
Shan Yu, Alexandr A. Kalinin, Maria D. Paraskevopoulou, Marco Maruggi, Jie Cheng, Jie Tang, Ilknur Icke, Yi Luo, Qun Wei, Dan Scheibe, Joel Hunter, Shantanu Singh, Deborah Nguyen, Anne E. Carpenter, Shane R. Horman
Intestinal fibrosis is a common complication of several enteropathies with inflammatory bowel disease being the major cause. The progression of intestinal fibrosis may lead to intestinal stenosis and obstruction. Even with an increased understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd5bc5b09f1f7f88c9f2db94b3cf4dc
https://doi.org/10.1101/2022.06.08.495258
https://doi.org/10.1101/2022.06.08.495258
Autor:
Emily Rowell, Jeremy To, Lilin Li, Frederick Lo, Shane R. Horman, Doug Quackenbush, Connor Reed
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Communications Biology
Communications Biology
Overcoming tumor-mediated immunosuppression and enhancing cytotoxic T-cell activity within the tumor microenvironment are two central goals of immuno-oncology (IO) drug discovery initiatives. However, exploratory assays involving immune components ar
Autor:
Whitney Barnes, John R. Walker, Loren Miraglia, Angelica Romero, Shane R. Horman, Jeremy To, Robbin Newlin, Taraka Sai Pavan Grandhi, Fabio Luna, Rita Moran, Anthony P. Orth
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(8)
Cancer is a disease of somatic mutations. These cellular mutations compete to dominate their microenvironment and dictate the disease outcome. While a therapeutic approach to target-specific oncogenic driver mutations helps to manage the disease, sub
Autor:
Emily Rowell, Frederick Lo, Shane R. Horman, Jeremy To, Doug Quackenbush, Connor Reed, Lilin Li
Publikováno v:
Communications Biology. 4
Overcoming tumor-mediated immunosuppression and enhancing cytotoxic T-cell activity within the tumor microenvironment are two central goals of immuno-oncology (IO) drug discovery initiatives. However, exploratory assays involving immune components ar
Autor:
Taraka Sai Pavan Grandhi, Rita Moran, Fabio Luna, Robbin Newlin, Loren Miraglia, Shane R. Horman, John R. Walker, Jeremy To, Whitney Barnes, Angelica Mendiola, Anthony Orth
Cancer is a disease of somatic mutations. These cellular mutations compete to dominate their microenvironment and dictate the disease outcome. While a therapeutic approach to target specific driver mutations helps to manage the disease, subsequent mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca823ac8b8b1c8c9b3296a6949f5ed82
https://doi.org/10.22541/au.160495230.05907247/v1
https://doi.org/10.22541/au.160495230.05907247/v1
Autor:
Shane R. Horman, Rita Moran, Robbin Newlin, Jocelyn Zoll, John R. Walker, Buu Tu, Nicole Leonetti, Jeremy To, John Lamb, Anthony P. Orth
Publikováno v:
Oncotarget
// Shane R. Horman 1 , Jeremy To 1 , John Lamb 2 , Jocelyn H. Zoll 3 , Nicole Leonetti 4, 7 , Buu Tu 5 , Rita Moran 6 , Robbin Newlin 6 , John R. Walker 4 and Anthony P. Orth 1 1 Functional Genomics, Genomics Institute of the Novartis Research Founda