Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shane M. Hart"'
Autor:
Sarva M. Tadepalli, Howard Ray Sauls, Yulin Wu, Andrew J. Carpenter, Yun Xu, Shane M. Hart, Daniel J. Gomez, Judith D. Kuntz, Jing Fang, Carina Ammala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2577-2581
A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3204ac2ccf78b0d83d6cb1e3e1e3c15a
https://doi.org/10.1016/j.bmcl.2010.02.083
https://doi.org/10.1016/j.bmcl.2010.02.083
Autor:
Gary R. Eldridge, Eliane Garo, Jin-Feng Hu, Chris M. Lee, Matt G. Goering, Peadar A. Cremin, Hye-Dong Yoo, Mark O’Neil-Johnson, Lu Zeng, Shane M. Hart, Helene C. Vervoort, Caroline T. Williams
Publikováno v:
Planta Medica. 71:176-180
High-throughput isolation, purification and analysis methods applied to natural products libraries from plants gave rise to the discovery of two novel acylated caprylic alcohol glycosides (1, 2) produced by Arctostaphylos pumila. The NMR spectra were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88ce73f753c6e64ca5c603c92bce7c3
https://doi.org/10.1055/s-2005-837787
https://doi.org/10.1055/s-2005-837787
Autor:
Gary R. Eldridge, Shane M. Hart, Chris M. Lee, Helene C. Vervoort, Caroline T. Williams, Matt G. Goering, and Mark O'Neil-Johnson, Peadar A. Cremin, Lu Zeng
Publikováno v:
Analytical Chemistry. 74:3963-3971
High-throughput methods were applied to the production, analysis, and characterization of libraries of natural products in order to accelerate the drug discovery process for high-throughput screening in the pharmaceutical and biotechnology industries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e1d6b1c8774e8af1692a0bf5ca157e
https://doi.org/10.1021/ac025534s
https://doi.org/10.1021/ac025534s
Autor:
Paul R. Johnson, Dallas K. Croom, Sarah R. Bullard, Sean Ross, Ronald L. Brashear, James M. Way, Christopher R. Conlee, Shane M. Hart, Carina Ammala, Vicente Samano, James B. Thompson, Doug Minick, Yun Xu, Dennis Heyer, Shane Roller, Eric E. Boros, Sarva M. Tadepalli, Peckham Gregory, Andrew J. Carpenter, Jennifer A. Kashatus, Subba Reddy Katamreddy, Howard Ray Sauls, Richard Dana Caldwell, Celia P. Briscoe
Publikováno v:
Journal of medicinal chemistry. 55(24)
GPR119 is a 7-transmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets of Langerhans in the pancreas. Indolines and 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines were discovered as G protein-coupled receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042ec05713cf4401600aefc83d2b88d2
https://pubmed.ncbi.nlm.nih.gov/23214471
https://pubmed.ncbi.nlm.nih.gov/23214471