Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shane G. Roller"'
Publikováno v:
Chemical Research in Toxicology. 14:511-516
Felbamate has proven to be an effective therapy for treating refractory epilepsy. However, felbamate therapy has been limited due to the associated reports of hepatotoxicity and aplastic anemia. Previous research from our laboratory has proposed 2-ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc03a0fb7d2e5569e67c5cdec469ac7f
https://doi.org/10.1021/tx000141e
https://doi.org/10.1021/tx000141e
Autor:
Bethany Purnell, Heather M. Townes, Carly A. Price, Virginia Carnahan, John David Trzupek, Moses Lee, Stephen J. Hudson, Konstantinos Kiakos, Kimberly Johnson, Kaitlin Summerville, Sara Centioni, Stanley Kupchinsky, Heather L. Handl, John A. Hartley, Tiffany T. Howard, Shane G. Roller, James L. Toth
Publikováno v:
Bioorganicmedicinal chemistry. 12(23)
The synthesis, DNA binding properties, and in vitro and in vivo anticancer activity of fifteen achiral seco-cyclopropylindoline (or achiral seco-CI) analogs (5a-o) of CC-1065 and the duocarmycins are described. The achiral seco-CI analogs contain a 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6704d6ec05802ce1376e2a6020a367d2
https://pubmed.ncbi.nlm.nih.gov/15519165
https://pubmed.ncbi.nlm.nih.gov/15519165
Publikováno v:
Chemico-biological interactions. 142(1-2)
Idiosyncratic drug reactions (IDR) are a specific type of drug toxicity characterized by their delayed onset, low incidence and reactive metabolite formation with little, if any, correlation between pharmacokinetics or pharmacodynamics and the toxico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6c951d428eec13650f216b949fe395
https://pubmed.ncbi.nlm.nih.gov/12399158
https://pubmed.ncbi.nlm.nih.gov/12399158
Autor:
Shane G. Roller, R. Duane Sofia, Timothy L. Macdonald, Webster L. Santos, Christine M. Dieckhaus
Publikováno v:
Chemical research in toxicology. 15(6)
Felbamate is an anti-epileptic drug associated with hepatotoxicity and aplastic anemia. These toxicities are believed to be mediated by the formation of the reactive species 2-phenylpropenal. 4-Hydroxy-5-phenyl-[1,3]oxazinan-2-one is a metabolic prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c791bfa68485b4c2ba8b647d92daaef
https://pubmed.ncbi.nlm.nih.gov/12067249
https://pubmed.ncbi.nlm.nih.gov/12067249
Autor:
Sharon A. Jennings, P. J. Burke, Natalie Brooks, John A. Hartley, Caroline O'Hare, Konstantinos Kiakos, Moses Lee, Shane G. Roller, James L. Toth
Publikováno v:
Heterocyclic Communications. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f703a54b1312346b1a11ba9640d89a2c
https://doi.org/10.1515/hc.2001.7.1.7
https://doi.org/10.1515/hc.2001.7.1.7
Autor:
Ray Feaster, Kari K. Cox, Moses Lee, Andrew Lam, James L. Toth, Brent Steadman, Michael A. Carnahan, Joey E. Espinosa, Shane G. Roller, Jennifer Azbell, Robert Hirsch
Publikováno v:
Journal of Chemical Education. 77:363
A collaborative and research-oriented advanced bioorganic chemistry project that probed the structure and reactivity relationship of yeast alcohol dehydrogenase (YADH) is reported. The project involved microscale and stereoselective reductions of ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb31b36aaad2242235eea0717b475221
https://doi.org/10.1021/ed077p363
https://doi.org/10.1021/ed077p363