Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shane E. Pullins"'
Publikováno v:
Neurobiol Aging
Brain aging is accompanied by an accumulation of damaged proteins, which results from deterioration of cellular quality control mechanisms and decreased protein degradation. The ubiquitin-proteasome system (UPS) is the primary proteolytic mechanism r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddc5059fd04a65df7092da8a9669025
https://doi.org/10.1016/j.neurobiolaging.2020.03.001
https://doi.org/10.1016/j.neurobiolaging.2020.03.001
Publikováno v:
Neuropsychopharmacology
The retrosplenial cortex (RSC) is extensively interconnected with the dorsal hippocampus and has several important roles in learning and memory. Recent work has demonstrated that certain types of context-dependent learning are selectively impaired wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0c8a7ae7d151fe188917b7775300a6
https://pubmed.ncbi.nlm.nih.gov/33580135
https://pubmed.ncbi.nlm.nih.gov/33580135
Publikováno v:
Neurobiology of Learning and Memory. 185:107526
Heightened fear responding is characteristic of fear- and anxiety-related disorders, including post-traumatic stress disorder. Neural plasticity in the amygdala is essential for both initial fear learning and fear expression, and strengthening of syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dfa0e171a6ed48013d2eda97976fe4
https://doi.org/10.1016/j.nlm.2021.107526
https://doi.org/10.1016/j.nlm.2021.107526
Publikováno v:
Learning & Memory. 24:589-596
Numerous studies have indicated that the consolidation of contextual fear memories supported by an aversive outcome like footshock requires de novo protein synthesis as well as protein degradation mediated by the ubiquitin–proteasome system (UPS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4444f1e9eaa4dd2fbfa128aa85112d7d
https://doi.org/10.1101/lm.045443.117
https://doi.org/10.1101/lm.045443.117
Autor:
Janine L. Kwapis, Sabrina A. Orsi, Fred J. Helmstetter, Shane E. Pullins, Sydney Trask, Timothy J. Jarome, Nicole C. Ferrara, Patrick K. Cullen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Associations learned during Pavlovian fear conditioning are rapidly acquired and long lasting, providing an ideal model for studying long-term memory formation, storage, and retrieval. During retrieval, these memories can “destabilize” and become
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0feb61985ed88c19351262cab95b41d
https://doi.org/10.1038/s41598-019-41526-1
https://doi.org/10.1038/s41598-019-41526-1
Publikováno v:
Neurobiol Learn Mem
The recall of a previously formed fear memory triggers a process through which synapses in the amygdala become “destabilized”. This labile state at retrieval may be critical for the plasticity required to modify, update, or disrupt long-term memo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396c714415e6e26378677b1be29cb03c
https://doi.org/10.1016/j.nlm.2019.107089
https://doi.org/10.1016/j.nlm.2019.107089
Publikováno v:
Hippocampus. 25:779-785
The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c31de44c928957eda9740d72f87625
https://doi.org/10.1002/hipo.22413
https://doi.org/10.1002/hipo.22413
Publikováno v:
Hippocampus. 25(7)
The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0eeecc7a7407b169cb590d94c59df453
https://pubmed.ncbi.nlm.nih.gov/25565270
https://pubmed.ncbi.nlm.nih.gov/25565270