Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Shane D Falcinelli"'
Autor:
Lijun Ling, Chandrav De, Rae Ann Spagnuolo, Nurjahan Begum, Shane D Falcinelli, Nancie M Archin, Martina Kovarova, Guido Silvestri, Angela Wahl, David M Margolis, J Victor Garcia
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011824 (2023)
Lifelong treatment is required for people living with HIV as current antiretroviral therapy (ART) does not eradicate HIV infection. Latently infected cells are essentially indistinguishable from uninfected cells and cannot be depleted by currently av
Externí odkaz:
https://doaj.org/article/a87f849c7c8a4bcfb65f46e62f664ed6
Autor:
Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART). However, full ta
Externí odkaz:
https://doaj.org/article/4373bee6f4264a5fa37799577488e1df
Autor:
Dajiang Li, Morgan G. Dewey, Li Wang, Shane D. Falcinelli, Lilly M. Wong, Yuyang Tang, Edward P. Browne, Xian Chen, Nancie M. Archin, David M. Margolis, Guochun Jiang
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103649- (2022)
Summary: The eradication of HIV infection is difficult to achieve because of stable viral reservoirs. Here, we show that crotonylation enhances AZD5582-induced noncanonical NF-κB (ncNF-κB) signaling, further augmenting HIV latency reversal in Jurka
Externí odkaz:
https://doaj.org/article/40baf72d802e42f5b3fd5261a4846a4b
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
A cure for HIV infection remains elusive due to the persistence of replication-competent HIV proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite or post-treatment controllers of viremia, withdrawal of ART in
Externí odkaz:
https://doaj.org/article/6ac190cb08ca49fcbcab8136c0cab08b
Autor:
Shane D. Falcinelli, Alicia D Cooper-Volkheimer, Lesia Semenova, Ethan Wu, Alexander Richardson, Manickam Ashokkumar, David M Margolis, Nancie M. Archin, Cynthia D Rudin, David Murdoch, Edward P Browne
HIV infection remains incurable due to the persistence of a viral reservoir during antiretroviral therapy. Cannabis (CB) use is prevalent amongst people with HIV (PWH), but the impact of CB on the latent HIV reservoir has not been investigated. Perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ee0d9e09781fc8510a5535f12ccec3
https://doi.org/10.1101/2022.12.22.521628
https://doi.org/10.1101/2022.12.22.521628
Autor:
Guochun Jiang, Dajiang Li, Shane D. Falcinelli, Lilly M. Wong, Yuyang Tang, Edward P. Browne, Nancie M. Archin, David M. Margolis
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Viruses, Vol 11, Iss 2, p 116 (2019)
Influenza viruses are a threat to global public health resulting in ~500,000 deaths each year. Despite an intensive vaccination program, influenza infections remain a recurrent, yet unsolved public health problem. Secondary bacterial infections frequ
Externí odkaz:
https://doaj.org/article/8adccd921bc64d08a832a8ed10a811bc
Autor:
Shane D. Falcinelli, Alicia Volkheimer, Lesia Semenova, Ethan Wu, Alexander Richardson, Manickam Ashokkumar, David M Margolis, Nancie M. Archin, Cynthia D Rudin, David Murdoch, Edward P Browne
Publikováno v:
Journal of Virus Eradication. 8:100232
Autor:
David M. Margolis, Katie R. Mollan, Jenna Read, Brigitte Allard, Caroline E. Baker, Nadia R. Roan, Simon Ghofrani, Joseph J. Eron, Adaora A. Adimora, Erin Stuelke, Jennifer Kirchherr, Shane D. Falcinelli, Nancie M. Archin, Katherine S James, Sumati Sridhar, Catalina Ramirez, Joann D. Kuruc, Bonnie E. Shook-Sa, Morgan G Dewey
Publikováno v:
J Infect Dis
The Journal of infectious diseases, vol 222, iss 11
The Journal of infectious diseases, vol 222, iss 11
Background Persistent HIV infection of long-lived resting CD4 T cells, despite antiretroviral therapy (ART), remains a barrier to HIV cure. Women have a more robust type 1 interferon response during HIV infection relative to men, contributing to lowe
Autor:
Jenna Read, Colin T. King, Maria Pino, Mirko Paiardini, Heather Amrine-Madsen, Michael Nekorchuk, Chi Ngai Chan, Cristin M. Galardi, Hong Wang, James Schawalder, Katharine J. Bar, A. Alicia Koblansky, Colleen S. McGary, Kevin Nguyen, Jacob D. Estes, Sherrie Jean, Samuel L. M. Raines, Shane D. Falcinelli, Jeffrey D. Lifson, Shari Gordon, Luca Micci, Guido Silvestri, Andrew Sanderson, Justin L. Harper, Brian Johns, David Favre, Emily Lindemuth, Kathleen Busman-Sahay, Barbara Cervasi, David M. Margolis
Publikováno v:
Nature Medicine. 26:519-528
The primary human immunodeficiency virus (HIV) reservoir is composed of resting memory CD4+ T cells, which often express the immune checkpoint receptors programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4),