Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shane A. Worthge"'
Autor:
Brett A. Barbaro, Anjalika Chongtham, Judith Purcell, Shane A. Worthge, Adeela Syed, Tamas Lukacsovich, Douglas J. Bornemann, Namita Agrawal, Theodore M Chin, John Burke, J. Lawrence Marsh
Publikováno v:
Hum Mol Genet
Human molecular genetics, vol 29, iss 4
Human molecular genetics, vol 29, iss 4
Huntington’s disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates. Here we ask whether expanded polyQ is sufficient to cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b611165a50f93caa4a48b5770038ec5
https://pubmed.ncbi.nlm.nih.gov/31943010
https://pubmed.ncbi.nlm.nih.gov/31943010
Autor:
Katrina G. Waymire, Emily M. Padilla, Yanete Rodriguez, Miles Pomeroy, Judith Purcell, A. Jane Bardwell, Shane A. Worthge, Antor Paul, Weijian Huang, Lee Bardwell, Cindy Park, Adeela Syed, Stephen R. Wei, Tamas Lukacsovich, Ronak Zebarjedi, Grant R. MacGregor, Thai Bin T. Pham, James Gui, Bing Zhang, Gentry T. Decker, J. Lawrence Marsh
Publikováno v:
Developmental biology, vol 445, iss 1
Analysis of mutants that affect formation and function of the Drosophila larval neuromuscular junction (NMJ) has provided valuable insight into genes required for neuronal branching and synaptic growth. We report that NMJ development in Drosophila re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ac6a7784b2d653d602d7808507b970
https://escholarship.org/uc/item/776483rk
https://escholarship.org/uc/item/776483rk
Autor:
Shane A. Worthge, Olga A. Morozova, David W. Colby, Doug J. Bornemann, Namita Agrawal, J. Lawrence Marsh, Judith Purcell, Tamas Lukacsovich, Andrea Caricasole, Brett A. Barbaro, Wan Song, Andreas Weiss, John Burke
Publikováno v:
Human Molecular Genetics. 24:913-925
Although Huntington's disease is caused by the expansion of a CAG triplet repeat within the context of the 3144-amino acid huntingtin protein (HTT), studies reveal that N-terminal fragments of HTT containing the expanded PolyQ region can be produced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9494b87f5caba28b1aae71303a1a81
https://doi.org/10.1093/hmg/ddu504
https://doi.org/10.1093/hmg/ddu504
Autor:
Shane A. Worthge, Adeela Syed, Letizia Magnoni, Michela Camarri, Liliana B. Menalled, J. Lawrence Marsh, Andrea Caricasole, Marco Gianfriddo, Enrica Diodato, Tamas Lukacsovich, Ruth Luthi-Carter, Ozgun Gokce, Judy Purcell, Marianne R. Smith, Luisa Massai, Sylvie Ramboz, Stephen R. Wei, Davide Franceschini, Russell J. Thomas, Giuseppe Pollio, G Westerberg, Bernard Landwehrmeyer, Carla Scali, Brett A. Barbaro, Carol Murphy, Sarah J. Tabrizi
Publikováno v:
Human molecular genetics, vol 23, iss 11
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212
Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a945f412d35a8fd0b971b3108edc54b4
https://escholarship.org/uc/item/91m8n212
https://escholarship.org/uc/item/91m8n212