Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shane A. Eisenbeis"'
Autor:
Brian P. Jones, Barbara J. Sitter, Ruchi Mehta, Anil Rane, Chad A. Lewis, Jacob C. DeForest, Elizabeth Greenberg, Nga M. Do, Emma McInturff, Bao D. Nguyen, Kris N. Jones, Michael J. Karmilowicz, Mark E. Webster, Howard W. Ward, Brian Samas, Sarah H. Griffin, Rajesh Kumar, Phil Dietrich, Christina G. Connor, Kevin M. Doyle, J. Christopher McWilliams, Shane A. Eisenbeis
Publikováno v:
Organic Process Research & Development. 25:608-615
The development of a commercial route toward the JAK1 inhibitor abrocitinib is described. The application of a late-stage Lossen rearrangement provided the desired cis-diaminocyclobutane, which was...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228cec856fc0df04979f86160b11f6dc
https://doi.org/10.1021/acs.oprd.0c00366
https://doi.org/10.1021/acs.oprd.0c00366
Publikováno v:
Organic Process Research & Development. 19:244-248
An efficient four-step synthesis of 1 is described in which utilization of ReactIR was key to efficient processing and reaction monitoring. Key chemical steps included (i) nucleophilic aromatic substitution, iron reduction of aromatic nitro group to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32ba6d8f1263455f3404fd48959d23ff
https://doi.org/10.1021/op5003165
https://doi.org/10.1021/op5003165
Publikováno v:
Tetrahedron Letters. 53:5467-5470
While optimizing the synthesis of pharmaceutical building block 3 [ethyl 1-(hydroxymethyl)-1,3-dihydroisobenzofuran-1-carboxylate], we encountered an unusual addition of an aryllithium reagent to the ketone oxygen atom of diethyl ketomalonate. Compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de32a21c3df2ff2643644683437a4e3
https://doi.org/10.1016/j.tetlet.2012.05.052
https://doi.org/10.1016/j.tetlet.2012.05.052
Autor:
Steven J. Brenek, John J. Teixeira, Robert A. Singer, Shane A. Eisenbeis, Weston Neil Philip, Brian C. Vanderplas, John A. Ragan, David J. am Ende, Derek L. Tickner
Publikováno v:
Organic Process Research & Development. 7:155-160
Several routes to bisulfite adduct 2 were explored, the most efficient of which involved vinyl Grignard addition to 2-indanone followed by ozonolysis and workup with aqueous NaHSO3 to effect reduction and bisulfite formation in a single pot. The safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b49970066f25cf4453446501f28d49d5
https://doi.org/10.1021/op0202235
https://doi.org/10.1021/op0202235
Autor:
Shane A. Eisenbeis, James E. Phillips
Publikováno v:
Synthetic Communications. 31:3533-3536
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cfeae20a8871abc306aa0c474ed0036
https://doi.org/10.1081/scc-100106215
https://doi.org/10.1081/scc-100106215
Publikováno v:
Tetrahedron Letters. 51:4303-4305
The reaction of benzyl 3-formylpiperidine-1-carboxylate and aryl hydrazines under standard Fisher Indole conditions followed by reductive work-up affords azepino[3,4b]indoles in moderate to good yields. The products are proposed to be derived via a P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c077222df4d6c2f0ac68c22c876ed6c6
https://doi.org/10.1016/j.tetlet.2010.06.029
https://doi.org/10.1016/j.tetlet.2010.06.029
Autor:
Robin A. Fairhurst, Shane A. Eisenbeis, Nicholas Magnus, Theodore Iliadis, Philip Magnus, David M. Parry
Publikováno v:
Journal of the American Chemical Society. 119:5591-5605
The synthesis of the 13-keto-10-azabicyclo[7.3.1]enediyne core structure of dynemicin A has been achieved by two routes, Schemes 4 and 6. The chemistry of the 13-keto core structure is dominated by the unusually facile bridgehead enolization. Compari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1c6cb2c2c03207d6346a4614a874ddd
https://doi.org/10.1021/ja970435v
https://doi.org/10.1021/ja970435v
Publikováno v:
ChemInform. 44
While optimizing the synthesis of pharmaceutical building block 3 [ethyl 1-(hydroxymethyl)-1,3-dihydroisobenzofuran-1-carboxylate], we encountered an unusual addition of an aryllithium reagent to the ketone oxygen atom of diethyl ketomalonate. Compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::685886c034e9957e49146119f220b28a
https://doi.org/10.1002/chin.201301099
https://doi.org/10.1002/chin.201301099
Publikováno v:
Tetrahedron Letters. 36:4539-4542
Enediyne model compounds containing the calicheamicin and dynemicin core skeleton can be brominated to give stable adducts, but in one case a deep-seated rearrangement takes place.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9c456646dcfced10bb780d91608a75
https://doi.org/10.1016/0040-4039(95)00823-u
https://doi.org/10.1016/0040-4039(95)00823-u
Publikováno v:
Synthesis. 2002:720-722
A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol (3) has been found to react with a variety of amidinium salts to afford the corresponding 2-substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f2713d6ccae8cd5fe901dc742d1022
https://doi.org/10.1055/s-2002-25767
https://doi.org/10.1055/s-2002-25767