Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shane, Gonen"'
Autor:
Stephen McCarthy, Shane Gonen
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract The δ‐conotoxins, a class of peptides produced in the venom of cone snails, are of interest due to their ability to inhibit the inactivation of voltage‐gated sodium channels causing paralysis and other neurological responses, but diffic
Externí odkaz:
https://doaj.org/article/4d68b81a071f4f89812384a78458b173
Autor:
Diana S. Suder, Shane Gonen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5665 (2024)
Many macromolecules are inherently flexible as a feature of their structure and function. During single-particle CryoEM processing, flexible protein regions can be detrimental to high-resolution reconstruction as signals from thousands of particles a
Externí odkaz:
https://doaj.org/article/4339da3ceca04925801bf73d5080fb69
Autor:
Stephen McCarthy, Shane Gonen
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e12280- (2022)
Symmetric protein assemblies play important roles in nature which makes them an attractive target for engineering. De novo symmetric protein complexes can be created through computational protein design to tailor their properties from first principle
Externí odkaz:
https://doaj.org/article/ca2b963ab29940809abafc77d94f9b25
Autor:
Shane, Gonen
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2215
In recent years, electron cryo-microscopy (CryoEM) has become a powerful method for the high-resolution studies of biological macromolecules. While CryoEM experiments can begin without additional microscopy steps, negative-stain EM can tremendously m
Autor:
Ron O. Dror, Rachael Kretsch, Yifan Cheng, Tara Arvedson, Alexander S. Powers, Shane Gonen, Christian B. Billesbølle, Simon Schneider, Aashish Manglik, Caleigh M. Azumaya
Publikováno v:
Nature, vol 586, iss 7831
Nature
Nature
The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by inducing ferroportin internalization and degradation1. Aberrant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea016a96ef6df3f74bd07bd640f67d05
https://escholarship.org/uc/item/77g2k8b4
https://escholarship.org/uc/item/77g2k8b4
Autor:
Caleigh M. Azumaya, Tara Arvedson, Shane Gonen, Rachael Kretsch, Christian Billesboelle, Simon Schneider, Alexander S. Powers, Ron O. Dror, Aashish Manglik, Yifan Cheng
The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin negatively regulates iron absorption and recycling by inducing ferroportin internalization and degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd1579371d42f63ced6bf6b4e7bc832
Autor:
Chantz Thomas, Shane Gonen, Daniel Ellis, David Baker, Neil P. King, Yuxi Liu, Jacob B. Bale, Tamir Gonen, William Sheffler, Todd O. Yeates, Duilio Cascio
Publikováno v:
Science. 353:389-394
Nature provides many examples of self- and co-assembling protein-based molecular machines, including icosahedral protein cages that serve as scaffolds, enzymes, and compartments for essential biochemical reactions and icosahedral virus capsids, which
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 13
Current single particle electron cryo-microscopy (cryo-EM) techniques can produce images of large protein assemblies and macromolecular complexes at atomic level detail without the need for crystal growth. However, proteins of smaller size, typical o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41017075460fe5ee019461265a503585
Autor:
Duilio Cascio, Tamir Gonen, Jacob B. Bale, Rachel U. Park, David Baker, Shane Gonen, Neil P. King, Yuxi Liu, Todd O. Yeates
Publikováno v:
Protein Science. 24:1695-1701
We recently reported the development of a computational method for the design of coassembling multicomponent protein nanomaterials. While four such materials were validated at high-resolution by X-ray crystallography, low yield of soluble protein pre
Autor:
Shane Gonen, David Baker, William Sheffler, Todd O. Yeates, Tamir Gonen, Neil P. King, Dan E. McNamara, Jacob B. Bale
Publikováno v:
Nature. 510:103-108
The self-assembly of proteins into highly ordered nanoscale architectures is a hallmark of biological systems. The sophisticated functions of these molecular machines inspire the development of methods to engineer novel self-assembling protein struct