Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Shanbo Yang"'
Autor:
Chao Wang, Yujing Zhang, Shanbo Yang, Lingyu Shi, Rong Rong, Tingting Zhang, Yudong Wu, Dongming Xing
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractA new series of 1H-pyrrolo[3,2-c]pyridine derivatives were designed and synthesised as colchicine-binding site inhibitors. Preliminary biological evaluations showed that most of the target compounds displayed moderate to excellent antitumor a
Externí odkaz:
https://doaj.org/article/f64cf30fe3d14e0bac180712344b0f19
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractA series of cis-restricted 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines as novel tubulin polymerisation inhibitors was designed based on molecular docking. Compound 9p, exhibited potent antiproliferative activity against HeLa, MCF-7, and A549 c
Externí odkaz:
https://doaj.org/article/20346a9d73e8457f95d03cd1b57f851a
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
In this work, a series of new diarylpyrimidine derivatives as microtubule destabilizers were designed, synthesized, and evaluated for anticancer activities. Based on restriction configuration strategy, we introduced the pyrimidine moiety containing t
Externí odkaz:
https://doaj.org/article/4ac1e4ba7c8f4174af36c6238eba83e3
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 10, Pp 105146- (2023)
Some novel 4-aryl-9H-carbazoles were designed as potential tubulin polymerization inhibitors through structural optimization and bioisosteric strategy. These compounds showed effective antiproliferative activities against a diverse set of cancer cell
Externí odkaz:
https://doaj.org/article/fef20283db844083b3465c663f87a13c
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 9, Pp 105015- (2023)
Neurodegenerative diseases, like Alzheimer's disease, Huntington's disease, Parkinson's disease, progressive supranuclear palsy, and frontotemporal dementia are among the refractory diseases that lack appropriate drugs and treatments. Numerous diseas
Externí odkaz:
https://doaj.org/article/e76a5a981603468e85d09149caa93e5b
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1694-1703 (2022)
BRDs proteins that recognise chromatin acetylation regulate gene expression, are epigenetic readers and master transcription coactivators. BRDs proteins are now emerging as targets for new therapeutic development. Blocking the function of any of BRDs
Externí odkaz:
https://doaj.org/article/972d442f7e2144a59fa7e46ce7436fc6
Autor:
Shanbo Yang, Chao Wang, Lingyu Shi, Jing Chang, Yujing Zhang, Jingsen Meng, Wenjing Liu, Jun Zeng, Renshuai Zhang, Yingchun Shao, Dongming Xing
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2755-2764 (2022)
A set of novel diarylpyridines as anti-tubulin agents were designed, synthesised using a rigid pyridine as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evaluated for their in vitro antiproliferative activ
Externí odkaz:
https://doaj.org/article/54bb24125c124900bb988da63e194a86
Autor:
Chao Wang, Yujing Zhang, Lingyu Shi, Shanbo Yang, Jing Chang, Yingjie Zhong, Qian Li, Dongming Xing
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1437-1453 (2022)
Proteolytic targeting chimaeras (PROTACs) have been developed as an effective technology for targeted protein degradation. PROTACs are heterobifunctional molecules that can trigger the polyubiquitination of proteins of interest (POIs) by recruiting t
Externí odkaz:
https://doaj.org/article/1bb81f185be94960847f7174c8cefb8e
Autor:
Chao Wang, Lingyu Shi, Shanbo Yang, Jing Chang, Wenjing Liu, Jun Zeng, Jingsen Meng, Renshuai Zhang, Dongming Xing
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Cancer threatens human health and life. Therefore, it is particularly important to develop safe and effective antitumor drugs. Microtubules, the main component of cytoskeleton, play an important role in maintaining cell morphology, mitosis, and signa
Externí odkaz:
https://doaj.org/article/2462a0cc022647e5bca15fc0465da036
Autor:
Jing Chang, Chao Wang, Shanbo Yang, Lingyu Shi, Yujing Zhang, Wenjing Liu, Jingsen Meng, Jun Zeng, Renshuai Zhang, Ning Liu, Dongming Xing
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 11, Pp 104253- (2022)
A new series of novel diarylpyrazole derivatives as microtubule destabilizers were synthesized and evaluated for the anti-proliferative activities. Anti-proliferative assays were performed on the human cervix adenocarcinoma cell line (HeLa) and human
Externí odkaz:
https://doaj.org/article/e1ef45760e5b40bbb7092f5b6bf4f7e6