Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shana R. Morel"'
Autor:
Radha Charan Dash, Jiachen Wen, Angela M. Zaino, Shana R. Morel, Lianne Q. Chau, Robert J. Wechsler-Reya, M. Kyle Hadden
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 265-276 (2021)
The glioma-associated family of transcription factors (GLI) have emerged as a promising therapeutic target for a variety of human cancers. In particular, GLI1 plays a central role as a transcriptional regulator for multiple oncogenic signaling pathwa
Externí odkaz:
https://doaj.org/article/34eced58f47c49659557437a8bf7db95
Autor:
M. Kyle Hadden, Shana R. Morel, Lianne Q. Chau, Robert J. Wechsler-Reya, Radha Charan Dash, Angela M. Zaino, Jiachen Wen
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 265-276 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
The glioma-associated family of transcription factors (GLI) have emerged as a promising therapeutic target for a variety of human cancers. In particular, GLI1 plays a central role as a transcriptional regulator for multiple oncogenic signaling pathwa
Autor:
Jiachen Wen, Radha Charan Dash, Angela M. Zaino, Noah J. Harrahill, Jackson T. Calhoun, Christopher O. Dusek, Shana R. Morel, Matthew Russolillo, M. Kyle Hadden
Publikováno v:
Bioorganic Chemistry. 132:106387
Publikováno v:
ACS Med Chem Lett
[Image: see text] We conducted a structure–activity relationship study to explore simplified analogues of the itraconazole (ITZ) scaffold for their ability to inhibit the hedgehog (Hh) signaling pathway. These analogues were based on exploring the
Autor:
Robert J. Wechsler-Reya, Radha Charan Dash, M. Kyle Hadden, Shana R. Morel, Kelly A. Teske, Lianne Q. Chau
Inhibition of the hedgehog (Hh) signaling pathway has been validated as a therapeutic strategy to treat basal cell carcinoma and holds potential for several other forms of human cancer. Itraconazole and posaconazole are clinically useful triazole ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c451bc3f50a49966bf26389d93932b
https://europepmc.org/articles/PMC6358021/
https://europepmc.org/articles/PMC6358021/