Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shana L, Posy"'
Autor:
E. Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Julia Guy, Philippe Lapointe, Jean-François Lavallée, Alain Martel, Serge Plamondon, Roger Rémillard, Edward Ruediger, François Tremblay, Shana L. Posy, Victor R. Guarino, Jeremy M. Richter, Jianqing Li, Anuradha Gupta, Muthalagu Vetrichelvan, T. J. Balapragalathan, Arvind Mathur, Ji Hua, Mario Callejo, Jocelyne Guay, Chi Shing Sum, Mary Ellen Cvijic, Carol Watson, Pancras Wong, Jing Yang, Michel Bouvier, David A. Gordon, Ruth R. Wexler, Anne Marinier
Publikováno v:
Journal of Medicinal Chemistry. 65:8843-8854
Protease-activated receptor 4 (PAR4) is a G-protein coupled receptor that is expressed on human platelets and activated by the coagulation enzyme thrombin. PAR4 plays a key role in blood coagulation, and its importance in pathological thrombosis has
Autor:
Emily C. Cherney, Liping Zhang, Julian Lo, Tram Huynh, Donna Wei, Vijay Ahuja, Claude Quesnelle, Gary L. Schieven, Alan Futran, Gregory A. Locke, Zeyu Lin, Laura Monereau, Charu Chaudhry, Jordan Blum, Sha Li, Mark Fereshteh, Bifang Li-Wang, Sanjeev Gangwar, Chin Pan, Colin Chong, Xiao Zhu, Shana L. Posy, John S. Sack, Ping Zhang, Max Ruzanov, Mary Harner, Fahad Akhtar, Gretchen M. Schroeder, Gregory Vite, Brian Fink
Publikováno v:
Journal of Medicinal Chemistry. 65:3518-3538
Autor:
Shana L. Posy, David A Critton, Stefan Ruepp, Ratna Kumar Sreekantha, Laxman Pasunoori, Dharmpal S. Dodd, Murali Subramanian, Andrew Watson, Percy H. Carter, Honghe Wan, Debarati Mazumder Tagore, Paul Davies, Shailesh Dudhgaonkar, Gary L. Schieven, Ratika Srivastava, Luisa Salter-Cid, Michael A. Poss, Alaric J. Dyckman, Mussari Christopher P
Publikováno v:
ACS Med Chem Lett
[Image: see text] The toll-like receptor (TLR) family is an evolutionarily conserved component of the innate immune system, responsible for the early detection of foreign or endogenous threat signals. In the context of autoimmunity, the unintended re
Autor:
Jean-François Lavallée, Yanou Yang, Carol A. Watson, Karen S. Hartl, Victor R. Guarino, Mark Gagnon, Timothy W. Harper, E. Scott Priestley, Jing Yang, Anne Marinier, Ruediger Edward H, Alain Martel, Dietmar A. Seiffert, Michel Bouvier, Ruth R. Wexler, Jacques Banville, Todd J. Friends, Roger Remillard, Michael M. Miller, Pancras C. Wong, Shana L. Posy, Ge Zhang, David G. Harden, Jonathan L. Josephs, Jon J. Hangeland, Harold R. O'Grady, R. Michael Lawrence, Sarah E. Malmstrom, Nick J. Allegretto, François Tremblay
Publikováno v:
Journal of medicinal chemistry. 62(16)
In an effort to identify novel antithrombotics, we have investigated protease-activated receptor 4 (PAR4) antagonism by developing and evaluating a tool compound, UDM-001651, in a monkey thrombosis model. Beginning with a high-throughput screening hi
Autor:
Litao Zhang, William J. Metzler, Shana L. Posy, Robert M. Borzilleri, Yuval Blat, Brigitte Devaux, Charu Chaudhry, Randy Talbott, Chunhong Yan, Yong Zhang, Jonathan H. Davis, Ming Lei, Henry Shen
Publikováno v:
Analytical Biochemistry. 497:8-17
XIAP (X-chromosome-linked inhibitor of apoptosis protein) is a central apoptosis regulator that blocks cell death by inhibiting caspase-3, caspase-7, and caspase-9 via binding interactions with the XIAP BIR2 and BIR3 domains (where BIR is baculovirus
Autor:
Yong Zhang, Ming Lei, Shana L. Posy, Kyoung S. Kim, Benjamin A. Seigal, Joseph Fargnoli, Stuart Emanuel, Percy H. Carter, Nicholas K. Terrett, Neha Surti, Robert M. Borzilleri, Henry Shen, Joseph G. Naglich, Matthew Pokross, Randy Talbott, Andrew Fraley, William H. Connors
Publikováno v:
Journal of Medicinal Chemistry. 58:2855-2861
Affinity selection screening of macrocycle libraries derived from DNA-programmed chemistry identified XIAP BIR2 and BIR3 domain inhibitors that displace bound pro-apoptotic caspases. X-ray cocrystal structures of key compounds with XIAP BIR2 suggeste
Autor:
Eric T. Baldwin, Nigel W. Moriarty, Matt Pokross, Herbert E. Klei, Thomas C. Terwilliger, Nathaniel Echols, Shana L. Posy, Paul D. Adams
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
A new module, Guided Ligand Replacement (GLR), has been developed in Phenix to increase the ease and success rate of ligand placement when prior protein-ligand complexes are available.
The process of iterative structure-based drug design involve
The process of iterative structure-based drug design involve
Autor:
Wayne Vaccaro, Jonathan Lippy, Mark A. Hermsmeier, Shana L. Posy, Gordon Todderud, Deborah A. Loughney, Karl-Heinz Ott, George L. Trainor, Stephen R. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 54:54-66
A kinome-wide selectivity screen of >20000 compounds with a rich representation of many structural classes has been completed. Analysis of the selectivity patterns for each class shows that a broad spectrum of structural scaffolds can achieve specifi
Autor:
Georgia Cornelius, Joseph Fargnoli, Joseph G. Naglich, Yong Zhang, Shana L. Posy, Benjamin A. Seigal, Charu Chaudhry, Ling Li, Yingru Zhang, Ragini Vuppugalla, Robert J. Schmidt, Percy H. Carter, Gregory D. Vite, Ming Lei, Martin Patrick Allen, Donna D. Wei, Chunlei Wang, Michael M. Miller, Randy Talbott, Robert M. Borzilleri, Nicholas K. Terrett
Publikováno v:
ACS medicinal chemistry letters. 6(7)
A series of dimeric macrocyclic compounds were prepared and evaluated as antagonists for inhibitor of apoptosis proteins. The most potent analogue 11, which binds to XIAP and c-IAP proteins with high affinity and induces caspase-3 activation and ulti
Autor:
David K. Williams, Charu Chaudhry, Robert M. Borzilleri, Liping Zhang, Randy Talbott, Kyoung S. Kim, Erik M. Stang, Ming Lei, Heidi L. Perez, Shana L. Posy, Stuart Emanuel
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(21)
Bivalent heterodimeric IAP antagonists that incorporate (R)-tetrahydroisoquinoline in the P3′ subunit show high affinity for the BIR2 domain and demonstrated potent IAP inhibitory activities in biochemical and cellular assays. Potent in vivo effica