Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Shana Elbaum"'
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Akademický článek
Sequestration within peptide coacervates improves the fluorescence intensity, kinetics, and limits of detection of dye-based DNA biosensors
Autor: Christopher M. Green, Deborah Sementa, Divita Mathur, Joseph S. Melinger, Priyasha Deshpande, Shana Elbaum-Garfinkle, Igor L. Medintz, Rein V. Ulijn, Sebastián A. Díaz
Publikováno v: Communications Chemistry, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Peptide-based liquid-liquid phase separated domains, or coacervates, are a biomaterial gaining new interest due to their exciting potential in fields ranging from biosensing to drug delivery. In this study, we demonstrate that coacervates pr
Externí odkaz: https://doaj.org/article/17560a3af1604411ac2b319cd3bed36b
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2
Akademický článek
Tunable multiphase dynamics of arginine and lysine liquid condensates
Autor: Rachel S. Fisher, Shana Elbaum-Garfinkle
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The design principles underlying biomolecular phase separation of membrane-less organelles remain poorly understood. Using model homopolymers, Fisher et al. show that the formation kinetics of coexisting liquid phases can be tuned by exploiting diffe
Externí odkaz: https://doaj.org/article/11f495e04dff484c867794c842249df7
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3
Connected Peptide Modules Enable Controlled Co-Existence of Self-Assembled Fibers Inside Liquid Condensates
Autor: Ankit Jain, Salma Kassem, Rachel S. Fisher, Biran Wang, Tai-De Li, Tong Wang, Ye He, Shana Elbaum-Garfinkle, Rein V. Ulijn
Publikováno v: Journal of the American Chemical Society. 144:15002-15007
Supramolecular self-assembly of fibrous components and liquid-liquid phase separation are at the extremes of the order-to-disorder spectrum. They collectively play key roles in cellular organization. It is still a major challenge to design systems wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de672586bcdb0ca0d7bd4f5fb2c07424
https://doi.org/10.1021/jacs.2c05897
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4
Liquid to solid transition of elastin condensates
Autor: Alfredo Vidal Ceballos, Jairo A. Díaz A, Jonathan M. Preston, Christo Vairamon, Christopher Shen, Ronald L. Koder, Shana Elbaum-Garfinkle
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(37)
Liquid–liquid phase separation of tropoelastin has long been considered to be an important early step in the complex process of elastin fiber assembly in the body and has inspired the development of elastin-like peptides with a wide range of indust
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514826af7411f93e7b94181b2d9b8904
https://pubmed.ncbi.nlm.nih.gov/36067308
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7
Protein charge parameters that influence stability and cellular internalization of polyelectrolyte complex micelles
Autor: Rachel A. Kapelner, Rachel S. Fisher, Shana Elbaum-Garfinkle, Allie C. Obermeyer
Publikováno v: Chemical science. 13(48)
Proteins are an important class of biologics, but there are several recurring challenges to address when designing protein-based therapeutics. These challenges include: the propensity of proteins to aggregate during formulation, relatively low loadin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5c2472d76222e0753dc09f03b16d65
https://pubmed.ncbi.nlm.nih.gov/36545145
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