Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Shan-Yen Chou"'
Publikováno v:
Molecules, Vol 28, Iss 17, p 6374 (2023)
In this paper, we report the synthesis of spirocyclopropane-containing 4H-pyrazolo[1,5-a]indoles 6a–e via alkylative dearomatization and intramolecular N-imination of indole–O-(methylsulfonyl)oxime 11. Starting materials tryptophol (7) and 2-brom
Externí odkaz:
https://doaj.org/article/e47f2638374949dabf64dbc4fe580076
Autor:
Shu Fu Lin, Li-Wei Teng, Ya-Chi Huang, Shyh-Fong Chen, Guan-Ru Huang, Chih-Lin Chang, Pi-Chen Hsu, Min-Sian Huang, Yu-Sheng Gao, Ya-Wen Chan, Jiann-Jyh Huang, Sheng-Chuan Yang, Bo-Han Jian, Yann-Yu Lu, Yu-Fen Chen, Tzu-Hao Lo, Shih-Hsien Chuang, Wen-Yun Hsueh, Po-Hsun Huang, Hsin-Yi Huang, Lien-Hsiang Chang, Win-Yin Wei, Ying-Chou Chen, Her-Sheng Lin, Shan-Yen Chou, Ta-Tung Yuan, Yu-Ting Chao, Ying-Shuan E. Lee, Yi-Feng Kao, Yu-Hsiang Lin, Jo-Chu Lin, Hung-Huang Liu, Shao-Yun Wang, Chin-Hung Lai, Shin-Yi Huang
Publikováno v:
Journal of Medicinal Chemistry. 64:1435-1453
In this paper, we present a copper(I)-catalyzed nitrile-addition/N-arylation ring-closure cascade for the synthesis of 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones from 2-(2-bromophenyl)-N-(2-cyanophenyl)acetamides. Using CuBr and t-BuONa in dimethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fcb962b8cc2da85f8b630161defbab0
https://doi.org/10.1021/acs.jmedchem.0c00727
https://doi.org/10.1021/acs.jmedchem.0c00727
Autor:
Wen-Yun, Hsueh, Ying-Shuan E, Lee, Min-Sian, Huang, Chin-Hung, Lai, Yu-Sheng, Gao, Jo-Chu, Lin, Yu-Fen, Chen, Chih-Lin, Chang, Shan-Yen, Chou, Shyh-Fong, Chen, Yann-Yu, Lu, Lien-Hsiang, Chang, Shu Fu, Lin, Yu-Hsiang, Lin, Pi-Chen, Hsu, Win-Yin, Wei, Ya-Chi, Huang, Yi-Feng, Kao, Li-Wei, Teng, Hung-Huang, Liu, Ying-Chou, Chen, Ta-Tung, Yuan, Ya-Wen, Chan, Po-Hsun, Huang, Yu-Ting, Chao, Shin-Yi, Huang, Bo-Han, Jian, Hsin-Yi, Huang, Sheng-Chuan, Yang, Tzu-Hao, Lo, Guan-Ru, Huang, Shao-Yun, Wang, Her-Sheng, Lin, Shih-Hsien, Chuang, Jiann-Jyh, Huang
Publikováno v:
Journal of medicinal chemistry. 64(3)
In this paper, we present a copper(I)-catalyzed nitrile-addition/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f6c10c7f95ae0e1e8f3936e79865440
https://pubmed.ncbi.nlm.nih.gov/33492141
https://pubmed.ncbi.nlm.nih.gov/33492141
Autor:
Tsai, Henry J.1,2,3 henryjtsai@yahoo.com, Shan-Yen Chou1,4 sychou@taigenbiotech.com.tw
Publikováno v:
Journal of Biomedical Science. 2009, Vol. 16, p1-12. 12p. 2 Diagrams, 1 Chart, 4 Graphs.
Autor:
Henry J. Tsai, Shan-Yen Chou
Publikováno v:
Drug Development Research. 72:247-258
A new class of insulin receptor activator with a hydroxyfuroic acid in place of a hydroxyquinone moiety is reported. The synthesis of 3-(1H-indol-3-yl)-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic acids (26–30) requires seven major steps. Key elements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f325cdb6ab215e698d160b4bdd33c5
https://doi.org/10.1002/ddr.20391
https://doi.org/10.1002/ddr.20391
Publikováno v:
Medicinal Chemistry Research. 19:565-575
The potent activities of many anticancer agents have been demonstrated by in vitro assays. However, their poor solubility may result in diminishing anticancer activities in vivo. Previously, we synthesized a series of bisacridine derivatives shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e37ff6a0a2fa8a5815cb7490757d57b
https://doi.org/10.1007/s00044-009-9213-9
https://doi.org/10.1007/s00044-009-9213-9
Autor:
Wei-Kung Yin, Shan-Yen Chou, Hsueh-O Chang, Shan-Shue Wang, Shih-Chung Hsu, Yi-Jen Lee, Lien-Shange Chang
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:735-748
The preparation and cytotoxicity properties of a series of Ne-substituted triamine-linked acridine dimers are described. Most acridine dimer derivatives reveal highly potent in vitro cytotoxicity properties and DNA binding activity. Several acridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92c5c34d50ab8eb57a2332f89f020a6
https://doi.org/10.1016/j.bmc.2006.10.054
https://doi.org/10.1016/j.bmc.2006.10.054
Publikováno v:
Steroids. 71:942-948
A mechanistic study on the nucleophilic substitution of a strictly geometric 21-bromo-3alpha-hydroxyl-3beta-methoxymethyl-5alpha-pregnan-20-one was described. Reaction of the alpha-bromoketone with excess lithium imidazole followed by the addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af375b91edf6b5ebfb2bdf268564614
https://doi.org/10.1016/j.steroids.2006.07.004
https://doi.org/10.1016/j.steroids.2006.07.004
Publikováno v:
Tetrahedron Letters. 47:7579-7582
3-Methoxy-4-aryl-furan-2,5-dicarboxylic acid (8) is selectively converted into its C-5 methylester (6) by treatment with methyl chloroformate followed by decarboxylation in one flask. Acylation of the resulting half ester with a 7-substituted indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad94405ec0e910656b910766794aebf9
https://doi.org/10.1016/j.tetlet.2006.08.076
https://doi.org/10.1016/j.tetlet.2006.08.076
Publikováno v:
Drug Development Research. 67:448-455
Non-enzymatic glycation is a Maillard reaction that occurs spontaneously between glucose and proteins and results in the accumulation of advanced glycation end products (AGEs), which are believed to be one of the causes for age-related tissue damage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fce806b42dff998a309d6ff87d039b6
https://doi.org/10.1002/ddr.20105
https://doi.org/10.1002/ddr.20105