Výsledky vyhledávání - "Shan-Liang Sun"

Akademický článek

Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics

Autor: Tian‐Hua Wei, Meng‐Yi Lu, Si‐Hui Yao, Yu‐Qi Hong, Jin Yang, Meng‐Yuan Zhang, Yu‐Qi Yin, Yu‐Jie Han, Qing‐Qing Li, Zi‐Xuan Wang, Yi‐Bo Wang, Zhen‐Jiang Tong, Yun Zhou, Wei‐Chen Dai, Yan‐Cheng Yu, Shan‐Liang Sun, Ye Yang, Nian‐Guang Li, Zhi‐Hao Shi

Publikováno v: MedComm – Oncology, Vol 3, Iss 1, Pp n/a-n/a (2024)

Abstract Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity. This review focuses on the structur

Externí odkaz: https://doaj.org/article/29262a2be1a6426fa1afb92378ccb3fb

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Akademický článek

Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia

Publikováno v: Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115905- (2023)

The therapeutic benefits of available FLT3 inhibitors for AML are limited by drug resistance, which is related to mutations, as well toxicity caused by off-target effects. In this study, we introduce a new small molecule FLT3 inhibitor called danatin

Externí odkaz: https://doaj.org/article/b4a16bb41b1041b8acc5195b558148af

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Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II

Publikováno v: Future Medicinal Chemistry. 15:57-71

Aim: The clinical benefits of FLT3 inhibitors against acute myeloid leukemia (AML) have been limited by selectivity and resistance mutations. Thus, to identify FLT3 inhibitors possessing high selectivity and potency is of necessity. Methods & results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4e2c6feedaad9225b8c2e4b4b234b20
https://doi.org/10.4155/fmc-2022-0231

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Scaffold-hopping of Linifanib to Design 6-Phenylisoxazolo[3,4-b]pyridin-3-amine Derivatives as FLT3 Inhibitors for Treating Acute Myeloid Leukemia

Publikováno v: Letters in Drug Design & Discovery. 20

Background: Acute myeloid leukemia (AML) is the most common type of blood cancer. Fms-like tyrosine kinase 3 (FLT3) is a member of the class III receptor tyrosine kinase family. Overexpression of FLT3 was found in 70-100% of patients with acute myelo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9250921b9447897024d7ae8b81f00588
https://doi.org/10.2174/1570180820666230519140242

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Medicinal Chemistry Strategies for the Development of Bruton’s Tyrosine Kinase Inhibitors against Resistance

Autor: Shan-Liang Sun, Shi-Han Wu, Ji-Bo Kang, Yi-Yuan Ma, Lu Chen, Peng Cao, Liang Chang, Ning Ding, Xin Xue, Nian-Guang Li, Zhi-Hao Shi

Publikováno v: Journal of Medicinal Chemistry. 65:7415-7437

Despite significant efficacy, one of the major limitations of small-molecule Bruton's tyrosine kinase (BTK) agents is the presence of clinically acquired resistance, which remains a major clinical challenge. This Perspective focuses on medicinal chem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ca716b6e50609f90af565ee8a6209b
https://doi.org/10.1021/acs.jmedchem.2c00030

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Synthesis and Biological Evaluation of 2-Amino-1-phenyl-benzimidazole Derivatives as BACE1 Inhibitors

Publikováno v: Letters in Drug Design & Discovery. 20

Background: Alzheimer’s disease (AD), a chronic neurodegenerative disorder predominantly occurs among the elderly, is the leading cause of dementia. The accumulation of β-amyloid (Aβ) is considered the main pathogenies of AD, and β-site APP-clea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39196b9a437c00d50c0a0593f56125f8
https://doi.org/10.2174/1570180820666230223151850

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Bufotenine and its derivatives: synthesis, analgesic effects identification and computational target prediction

Autor: Xiao-Long Wang, Chao Zhao, Nian-Guang Li, Shan-Liang Sun, Han Xu, Hong-Yue Ma, He-Min Li, Huan-Huan Chen, Yue Zhong, Min Chen, Jiao-Jiao Wang

Publikováno v: Chinese Journal of Natural Medicines. 19:454-463

Natural product bufotenine (5) which could be isolated from Venenum Bufonis, has been widely used as a tool in central nervous system (CNS) studies. We present here its quaternary ammonium salt (6) which was synthesized with high yields using 5-benzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c355c71813aa277fb6e2b20c66be6dfd
https://doi.org/10.1016/s1875-5364(21)60044-4

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