Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shan Hwu Chew"'
Publikováno v:
Biomedical Journal, Vol 46, Iss 1, Pp 122-133 (2023)
Background: K63-linked polyubiquitination of proteins have nonproteolytic functions and regulate the activity of many signal transduction pathways. USP7, a HIF1α deubiquitinase, undergoes K63-linked polyubiquitination under hypoxia. K63-polyubiquiti
Externí odkaz:
https://doaj.org/article/183e7ae836344763929c89de4ad880b4
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Hypoxia and acidity provide microenvironment for selection under evolutionary pressure and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of metalloenzymes present in all life kingdoms, equilibrating the reactions among CO
Externí odkaz:
https://doaj.org/article/e53bd396485f4fd8ac8f8bce553bfa7b
Autor:
Hiroki Ohara, Li Jiang, Shan Hwu Chew, Yoriko Yamashita, Shinya Akatsuka, Takashi Takahashi, Yasumasa Okazaki, Hirotaka Nagai, Shinya Toyokuni
Publikováno v:
Cancer Science
Malignant mesothelioma (MM) is one of the most lethal tumors in humans. The onset of MM is linked to exposure to asbestos, which generates reactive oxygen species (ROS). ROS are believed to be derived from the frustrated phagocytosis and the iron in
Publikováno v:
Biomed J
BACKGROUND: K63-linked polyubiquitination of proteins have nonproteolytic functions and regulate the activity of many signal transduction pathways. USP7, a HIF1α deubiquitinase, undergoes K63-linked polyubiquitination under hypoxia. K63-polyubiquiti
Autor:
Young-Man Cho, Shan Hwu Chew, Satomi Funahashi, Yasumasa Okazaki, Kumiko Ogawa, Hirotaka Nagai, Takeshi Toyoda, Shinya Toyokuni
Publikováno v:
Journal of Toxicologic Pathology
Fibroadenoma (FA) is a common mammary fibroepithelial tumor. The tumor size of the FA is increased by estrogen, progesterone, prolactin, and pregnancy, whereas it decreases after menopause. These observations in humans indicate that FA is hormone dep
Autor:
Yoshitaka Sekido, Shan Hwu Chew, Shenqi Wang, Yuuki Ohara, Shinya Toyokuni, Daiki Somiya, Nobuaki Misawa, Kenneth E. Lipson, Yuta Tsuyuki, Kae Nakamura, Hiroaki Kajiyama, Kyoko Yamashita, Fumitaka Kikkawa, Li Jiang
Publikováno v:
Oncotarget
// Yuuki Ohara 1 , Shan Hwu Chew 1 , Nobuaki Misawa 1 , Shenqi Wang 1 , Daiki Somiya 1 , Kae Nakamura 2 , Hiroaki Kajiyama 2 , Fumitaka Kikkawa 2 , Yuta Tsuyuki 3 , Li Jiang 1 , Kyoko Yamashita 1 , Yoshitaka Sekido 4 , Kenneth E. Lipson 5 and Shinya
Autor:
Yuuki Ohara, Shan-Hwu Chew, Shinya Toyokuni, Takahiro Shibata, Kyoko Yamashita, Yasumasa Okazaki
Publikováno v:
Cancer Science
Malignant mesothelioma (MM) is a rare but socially important neoplasm due to its association with asbestos exposure. Malignant mesothelioma is difficult to diagnose at an early stage, yet there are no particularly effective treatments available at th
Autor:
Akihiko Sakamoto, Takahiro Nishiyama, Takashi Takahashi, Hiromu Suzuki, Li Jiang, Mitsuru Futakuchi, Shinya Akatsuka, Shan Hwu Chew, Guang Hua Li, Yusaku Nakabeppu, Shinya Toyokuni, Kunihiko Sakumi
Publikováno v:
Pathology International. 67:564-574
Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic
Publikováno v:
Redox Biology, Vol 26, Iss, Pp-(2019)
Redox Biology
Redox Biology
Hypoxia and acidity provide microenvironment for selection under evolutionary pressure and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of metalloenzymes present in all life kingdoms, equilibrating the reactions among CO
Autor:
Yuuki Ohara, Shan Hwu Chew, Yi-Peng Han, Takayuki Fukui, Shenqi Wang, Shinya Akatsuka, Koji Kawaguchi, Li Jiang, Shinya Toyokuni, Kohei Yokoi, Yoshitaka Sekido, Liang Weng
Publikováno v:
Oncotarget
// Shenqi Wang 1 , Li Jiang 1 , Yipeng Han 2 , Shan Hwu Chew 1 , Yuuki Ohara 1 , Shinya Akatsuka 1 , Liang Weng 2 , Koji Kawaguchi 3 , Takayuki Fukui 3 , Yoshitaka Sekido 4, 5 , Kohei Yokoi 3 , Shinya Toyokuni 1 1 Department of Pathology and Biologic