Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Shan Goh"'
Autor:
Haitham Hussain, Amer Nubgan, César Rodríguez, Korakrit Imwattana, Daniel R. Knight, Valerija Parthala, Peter Mullany, Shan Goh
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Clostridioides difficile is an emerging pathogen of One Health significance. Its highly variable genome contains mobile genetic elements (MGEs) such as transposons and prophages that influence its biology. Systematic deletion of each genetic element
Externí odkaz:
https://doaj.org/article/5a31a494606f40a49add97498e7cd619
Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/8262e2f3e973498682bdb80062519e8c
Autor:
Shan Goh, Jeannine Kolakowski, Angela Holder, Mark Pfuhl, Daniel Ngugi, Keith Ballingall, Kata Tombacz, Dirk Werling
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
East Coast Fever (ECF), caused by the tick-borne apicomplexan parasite Theileria parva, remains one of the most important livestock diseases in sub-Saharan Africa with more than 1 million cattle dying from infection every year. Disease prevention rel
Externí odkaz:
https://doaj.org/article/aa7c9e5d52604a3780387d499f3bdf02
Autor:
Valwynne Faulkner, Adrienne Adele Cox, Shan Goh, Annelies van Bohemen, Amanda J. Gibson, Oliver Liebster, Brendan W. Wren, Sam Willcocks, Sharon L. Kendall
Publikováno v:
Frontiers in Microbiology, Vol 11 (2021)
A greater understanding of the genes involved in antibiotic resistance in Mycobacterium tuberculosis (Mtb) is necessary for the design of improved therapies. Clustered regularly interspaced short palindromic repeat interference (CRISPRi) has been pre
Externí odkaz:
https://doaj.org/article/51e37f4e6d994235b5cd43995bc649ef
Publikováno v:
Heliyon, Vol 6, Iss 6, Pp e04110- (2020)
Genotypic based detection methods using specific target sites in the pathogen genome can complement phenotypic identification. We report the development of species-specific antisense peptide nucleic acid (PNA) combined with selective and differential
Externí odkaz:
https://doaj.org/article/2973d1cf1f43484f9dbd322a975864e1
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Until recently, Clostridium difficile phages were limited to Myoviruses and Siphoviruses of medium genome length (32–57 kb). Here we report the finding of phiCD5763, a Siphovirus with a large extrachromosomal circular genome (132.5 kb, 172 ORFs) an
Externí odkaz:
https://doaj.org/article/e89f72aed69445ffb904ce0d5afb346e
Autor:
Shan Goh, Daniel Ngugi, Regina Lizundia, Isabel Hostettler, Kerry Woods, Keith Ballingall, Niall D MacHugh, W Ivan Morrison, Willie Weir, Brian Shiels, Dirk Werling
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162571 (2016)
As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata and T. parva in cattle. Five
Externí odkaz:
https://doaj.org/article/9bdff7d4b71c40cfb57718abcffd4b3b
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89082 (2014)
Broad-spectrum antimicrobials kill indiscriminately, a property that can lead to negative clinical consequences and an increase in the incidence of resistance. Species-specific antimicrobials that could selectively kill pathogenic bacteria without ta
Externí odkaz:
https://doaj.org/article/1e475554dc434c359f5cefc7ae93f280
Publikováno v:
mBio, Vol 4, Iss 6 (2013)
ABSTRACT In this work, we show that Clostridium difficile phage ϕC2 transduces erm(B), which confers erythromycin resistance, from a donor to a recipient strain at a frequency of 10−6 per PFU. The transductants were lysogenic for ϕC2 and containe
Externí odkaz:
https://doaj.org/article/b70367b2f36a45f1a5af31a3cadcb6c9
Publikováno v:
Emerging Infectious Diseases, Vol 15, Iss 3, Pp 489-491 (2009)
Merkel cell polyomavirus (MCPyV), associated with Merkel cell carcinoma, was detected in 27 of 635 nasopharyngeal aspirate samples by real-time PCR. MCPyV was more commonly found in adults than in children. Presence in the upper respiratory tract may
Externí odkaz:
https://doaj.org/article/65dbb64e18144c298d5e5e97e4106e70