Anesthesia/surgery leads to blood-brain barrier disruption via the transcellular and paracellular pathways, and postoperative delirium-like behavior: A comparative study in mice of different ages.

Autor: Hu X; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China., Liu L; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China., Da X; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China., Zhu S; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China., Wang J; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China., Shan M; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China., Liu Y; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China., He Z; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China., Xu G; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Anesthesiology and perioperative Medicine of Anhui higher Education institutes, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China. Electronic address: xuguanghonghf2004@163.com.

Publikováno v: Experimental neurology [Exp Neurol] 2024 Nov 05; Vol. 383, pp. 115044. Date of Electronic Publication: 2024 Nov 05.