Zobrazeno 1 - 10
of 494
pro vyhledávání: '"Shan, Cen"'
Autor:
Kai Lv, Zhenlei Yu, Jing Wang, Na Li, Apeng Wang, Tiezheng Xue, Qixin Wang, Yanqin Shi, Lu Han, Wei Qin, Jiaqi Gong, Huijuan Song, Tingting Zhang, Chunyan Chang, Hua Chen, Xijun Zhong, Jian Ding, Rui Chen, Mingliang Liu, Weiguo Zhang, Shan Cen, Yijie Dong
Publikováno v:
Advanced Science, Vol 11, Iss 45, Pp n/a-n/a (2024)
Abstract The safety and efficacy of the lipid nanoparticle (LNP) delivery system are crucial for the successful development of messenger RNA vaccines. We designed and synthesized a series of ketal ester lipids (KELs), featuring a biodegradable ketal
Externí odkaz:
https://doaj.org/article/689e21e9de5c4ff1a232a07db157ba74
Autor:
Dongrong Yi, Ni An, Quanjie Li, Qian Liu, Huihan Shao, Rui Zhou, Jing Wang, Yongxin Zhang, Ling Ma, Fei Guo, Xiaoyu Li, Zhenlong Liu, Shan Cen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2520-2536 (2024)
Type I interferon (IFN) inhibits a wide spectrum of viruses through stimulating the expression of antiviral proteins. As an IFN-induced protein, myxovirus resistance B (MXB) protein was reported to inhibit multiple highly pathogenic human viruses. It
Externí odkaz:
https://doaj.org/article/83310836f69e477fba2ba64d410f6ae6
Publikováno v:
Experimental Gerontology, Vol 194, Iss , Pp 112499- (2024)
Objectives: Lifelong learning facilitates active ageing, and intragenerational learning—the process by which older adults learn from their peers—is an effective means of achieving this goal. The present research aims to elucidate the mechanisms a
Externí odkaz:
https://doaj.org/article/ef85d0933ebf4046a65a66b65510f7f8
Autor:
Caihong Wang, Mingxing Chen, Yuhan Shao, Mengyuan Jiang, Quanjie Li, Lihong Chen, Yun Wu, Shan Cen, Nicholas R. Waterfield, Jian Yang, Guowei Yang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Type VI secretion systems (T6SSs) deliver effectors into target cells. Besides structural and effector proteins, many other proteins, such as adaptors, co-effectors and accessory proteins, are involved in this process. MIX domains can assist
Externí odkaz:
https://doaj.org/article/2a5605ecbe1f4c5e8063af964e266eec
Autor:
Jiwei Ding, Shujie Wang, Qipeng Liu, Yuqing Duan, Tingting Cheng, Zhongjie Ye, Zhanding Cui, Ao Zhang, Qiuyu Liu, Zixiong Zhang, Ning Zhang, Qian Liu, Ni An, Jianyuan Zhao, Dongrong Yi, Quanjie Li, Jing Wang, Yongxin Zhang, Ling Ma, Saisai Guo, Jinhui Wang, Chen Liang, Jinming Zhou, Shan Cen, Xiaoyu Li
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107968- (2023)
Summary: Long interspersed element 1 (LINE-1) is the only currently known active autonomous transposon in humans, and its retrotransposition may cause deleterious effects on the structure and function of host cell genomes and result in sporadic genet
Externí odkaz:
https://doaj.org/article/a874c567f5d344b7b3f7258a95bf08e8
Autor:
Tao Zhang, Guowei Gu, Guodong Liu, Jinhua Su, Zhilai Zhan, Jianyuan Zhao, Jinxiu Qian, Guowei Cai, Shan Cen, Dewu Zhang, Liyan Yu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 256-270 (2023)
Oxalicine B (1) is an α-pyrone meroterpenoid with a unique bispirocyclic ring system derived from Penicillium oxalicum. The biosynthetic pathway of 15-deoxyoxalicine B (4) was preliminarily reported in Penicillium canescens, however, the genetic bas
Externí odkaz:
https://doaj.org/article/edacd8886c674f4cae33900621102d21
Autor:
Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drug
Externí odkaz:
https://doaj.org/article/ffbcda39b3154046b3276edad622a296
Autor:
Dongrong Yi, Quanjie Li, Han Wang, Kai Lv, Ling Ma, Yujia Wang, Jing Wang, Yongxin Zhang, Mingliang Liu, Xiaoyu Li, Jianxun Qi, Yi Shi, George F. Gao, Shan Cen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 12, Pp 4378-4389 (2022)
Ebola virus (EBOV) infection leads to staggeringly high mortality rate. Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa. In this study, we report that a natural compound called berbamine hydrochlorid
Externí odkaz:
https://doaj.org/article/6584f2d9c9894167abc340200ae813b4
Autor:
Ningning Cheng, Nan Jiang, Yuanhui Fu, Zhuxin Xu, Xianglei Peng, Jiemei Yu, Shan Cen, Yucheng Wang, Guoning Zhang, Yanpeng Zheng, Jinsheng He
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2598-2604 (2022)
Human respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection worldwide. Until now, there are no licenced vaccines or effective antiviral drugs against RSV infections. In our previous work, we found 2-((1H-indol-3-yl
Externí odkaz:
https://doaj.org/article/f98c48b8282c489c91b711c9c99beb69
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 11, Pp 4193-4203 (2022)
Investigation on how nature produces natural compounds with chemical and biological diversity at the genetic level offers inspiration for the discovery of new natural products and even their biological targets. The polyketide rumbrin (1) is a lipid p
Externí odkaz:
https://doaj.org/article/bc115997ac0247aeb99045bdfb9234e0