Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Shamzah Araf"'
Autor:
Shamzah Araf, Koorosh Korfi, Findlay Bewicke-Copley, Jun Wang, Sergio Cogliatti, Emil Kumar, Flavio Forrer, Sally F. Barrington, Trevor A. Graham, David W. Scott, Lisa M. Rimsza, Andrew Davies, Peter Johnson, Jessica Okosun, Jude Fitzgibbon, Martin Fehr
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/75decc114cbb4098829845955d245c47
Autor:
Shamzah Araf, Jun Wang, Margaret Ashton-Key, Koorosh Korfi, Doriana Di Bella, Ana Rio-Machin, Mariette Odabashian, Vipul Foria, Ming-Qing Du, Francesco Cucco, Sharon Barrans, Peter Johnson, Sophie R. Laird, Andrew M. Fisher, Jonathan O. Cullis, Trevor A. Graham, Jessica Okosun, Jude Fitzgibbon, Laura Chiecchio
Publikováno v:
Haematologica, Vol 104, Iss 4 (2019)
Externí odkaz:
https://doaj.org/article/9c978eeedf684e758ab8e3dfc16c178b
Autor:
Findlay Bewicke-Copley, Koorosh Korfi, Shamzah Araf, Brendan Hodkinson, Emil Kumar, Thomas Cummin, Margaret Ashton-Key, Sharon Barrans, Suzan van Hoppe, Cathy Burton, Mohamed Elshiekh, Simon Rule, Nicola Crosbie, Andrew Clear, Maria Calaminici, Hendrik Runge, Robert K. Hills, David W. Scott, Lisa M. Rimsza, Geetha Menon, Chulin Sha, John R. Davies, Ai Nagano, Andrew Davies, Daniel Painter, Alexandra Smith, John Gribben, Kikkeri N. Naresh, David R. Westhead, Jessica Okosun, Andrew Steele, Daniel J. Hodson, Sriram Balasubramanian, Peter Johnson, Jun Wang, Jude Fitzgibbon
Publikováno v:
Blood Advances. 7:845-855
Despite the effectiveness of immuno-chemotherapy, 40% of patients with diffuse large B-cell lymphoma (DLBCL) experience relapse or refractory disease. Longitudinal studies have previously focused on the mutational landscape of relapse but fell short
Autor:
Megan Perrett, Lucy Pickard, Emil Kumar, Giuseppe Palladino, Faraz Khan, Carina Edmondson, Connor Knight, Edward Poynton, Janet Matthews, Shamzah Araf, Andrew James Clear, Maria Calaminici, John G. Gribben, Hamish King, Mirjana Efremova, Jun Wang, Jessica Okosun
Publikováno v:
Blood. 140:748-749
Autor:
Flavio Forrer, Martin Fehr, Jude Fitzgibbon, Sergio Cogliatti, Lisa M. Rimsza, Jun Wang, Peter Johnson, Jessica Okosun, Findlay Bewicke-Copley, Andrew Davies, David W. Scott, Emil Kumar, Sally F. Barrington, Trevor A. Graham, Koorosh Korfi, Shamzah Araf
Publikováno v:
Haematologica
Autor:
Emanuela Carlotti, Filomena Spada, Francesco Forconi, Mariette Odabashian, Sergey Krysov, John G. Gribben, Mariarita Calaminici, Freda K. Stevenson, Jessica Okosun, Shamzah Araf
Publikováno v:
Blood. 135:834-844
Follicular lymphoma B cells undergo continuous somatic hypermutation (SHM) of their immunoglobulin variable region genes, generating a heterogeneous tumor population. SHM introduces DNA sequences encoding N-glycosylation sites asparagine-X-serine/thr
Autor:
Karina Close, Jun Wang, Tahrima Rahim, Sameena Iqbal, Findlay Bewicke-Copley, Andrew Clear, Martin Philpott, Annalisa D'Avola, Lola Konali, James A. Heward, Emil Kumar, Udo Oppermann, Richard Neve, Maria Calaminici, Pedro R. Cutillas, Jessica Okosun, Peter Johnson, Koorosh Korfi, John G. Gribben, Darko Barisic, Ahad F. Al Seraihi, James E. Dunford, Alison Yeomans, Ari Melnick, Shamzah Araf, Jude Fitzgibbon, Graham Packham
Publikováno v:
Blood
Loss-of-function mutations in KMT2D are a striking feature of germinal center (GC) lymphomas, resulting in decreased histone 3 lysine 4 (H3K4) methylation and altered gene expression. We hypothesized that inhibition of the KDM5 family, which demethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69f75b8e11d8e8cb74d2e87d8a74550
https://ora.ox.ac.uk/objects/uuid:7efc616c-0a6f-4725-8739-6ff679a99852
https://ora.ox.ac.uk/objects/uuid:7efc616c-0a6f-4725-8739-6ff679a99852
Autor:
Lola Koniali, Karina Close, Richard Neve, Maria Calaminici, Martin Philpott, Tahrima Rahim, Ahad F. Al Seraihi, Alison Yeomans, John G. Gribben, Findlay Bewicke-Copley, Andrew Clear, Jude Fitzgibbon, Graham Packham, James A. Heward, Jessica Okosun, Koorosh Korfi, Emil Kumar, Peter Johnson, Sameena Iqbal, Ari Melnick, Shamzah Araf, Udo Oppermann, James E. Dunford, Jun Wang, Annalisa D'Avola, Darko Barisic
Loss-of-function mutations in KMT2D are a striking feature of the germinal centre (GC) lymphomas, resulting in decreased H3K4 methylation and altered gene expression. We hypothesised that inhibition of the KDM5 family, which demethylates H3K4me3/me2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::767ce07069098562f94d88c6d06275e7
https://doi.org/10.1101/2020.06.30.177477
https://doi.org/10.1101/2020.06.30.177477
Autor:
Rifca Le Dieu, Krzysztof Zegocki, John G. Gribben, Belen Sevillano, Rebecca Auer, Heather Oakervee, Simon Hallam, Silvia Montoto, Bela Wrench, Jessica Okosun, Jamie Cavenagh, Matthew Smith, Edward Truelove, James Aries, John Riches, Shamzah Araf, Thomas Erblich, Jeff K. Davies, Vanessa Foggo, Samir G. Agrawal
Publikováno v:
British Journal of Haematology
Since being identified in China in December 2019, coronavirus disease 2019 (Covid‐19) has rapidly evolved into a global pandemic with over 4 million cases and more than 270,000 deaths.(1) Following the first reported cases in the United Kingdom (UK
Autor:
Andrew M. Fisher, Laura Chiecchio, Margaret Ashton-Key, Jessica Okosun, Sophie R. Laird, Doriana Di Bella, Peter Johnson, Mariette Odabashian, Jude Fitzgibbon, Jun Wang, Ana Rio-Machin, Vipul Foria, Sharon Barrans, Shamzah Araf, Francesco Cucco, Trevor A. Graham, Ming-Qing Du, Jonathan O. Cullis, Koorosh Korfi
Publikováno v:
Haematologica. 104:e174-e177
Cancer development is an evolutionary process driven by the acquisition of stochastic mutations, some of which increase cellular fitness in a co-evolving microenvironment.[1][1] Evidence across multiple cancer types demonstrates that this process is