Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Shamshad, Cockcroft"'
Autor:
Stuart Leishman, Najd M. Aljadeed, Liyunhe Qian, Shamshad Cockcroft, Jacques Behmoaras, Paras K. Anand
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114516- (2024)
Summary: Despite its significance, the role of lipid metabolism in NLRP3 inflammasome remains elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in NLRP3 inflammasome activation. We demonstrate that pharmacological or genetic dep
Externí odkaz:
https://doaj.org/article/7df8d54df58543839723b9bca08ac6c3
Autor:
Shamshad Cockcroft, Sima Lev
Publikováno v:
Contact, Vol 3 (2020)
Phosphatidylinositol (PI)-transfer proteins (PITPs) have been long recognized as proteins that modulate phosphoinositide levels in membranes through their intrinsic PI/PC-exchange activity. Recent studies from flies and mammals suggest that certain P
Externí odkaz:
https://doaj.org/article/2832c8855b5d4a5a8044e81aa2688568
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles in cells. PI can be phosphorylated and these phosphorylated derivativ
Externí odkaz:
https://doaj.org/article/94efd59531fd4423b07ed2a97174aaab
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1389-1396 (2018)
Summary: The lipid transporters of the phosphatidylinositol transfer protein (PITP) family dictate phosphoinositide compartmentalization, and specific phosphoinositides play crucial roles in signaling cascades, membrane traffic, ion channel regulatio
Externí odkaz:
https://doaj.org/article/708aed518a504b9bb88aff456b8ddcac
Autor:
Liang Zhao, Chelsea L. Thorsheim, Aae Suzuki, Timothy J. Stalker, Sang H. Min, Lurong Lian, Gregory D. Fairn, Shamshad Cockcroft, Amy Durham, Sriram Krishnaswamy, Charles S. Abrams
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Platelets support tumor metastasis formation. Here, the authors show that the phosphoinositide signaling modulated by PITPα is essential for platelet-mediated tumor metastasis signaling, but surprisingly it is dispensable in hemostasis in mice.
Externí odkaz:
https://doaj.org/article/036c8227c25d4741b3094639be983c32
Autor:
Charles S. Abrams, Liang ZHAO, Chelsea L Thorsheim, Aae Suzuki, Timothy J. Stalker, Sang Hee Min, Sriram Krishnaswamy, Shamshad Cockcroft, Karen E Anderson, Brittany Weiderhold
Publikováno v:
Blood Advances.
Platelets utilize signal transduction pathways facilitated by Class I phosphatidylinositol transfer proteins (PITPs). The two mammalian Class I PITPs, PITPα and PITPβ, are single PITP domain soluble proteins that are encoded by different genes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f1f17977bf7c5bec6f6788d205d48ed
https://doi.org/10.1182/bloodadvances.2022008735
https://doi.org/10.1182/bloodadvances.2022008735
Autor:
Shamshad Cockcroft
Publikováno v:
Essays in Biochemistry
Lipids are essential constituents of cellular membranes. Once regarded merely as structural components, lipids have taken centre stage with the discovery of their roles in cell signalling and in the generation of bioactive metabolites. Lipids regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dad9bf8b2855a501437657d52360f14
http://europepmc.org/articles/PMC8578989
http://europepmc.org/articles/PMC8578989
Autor:
Dominik Šťastný, Lívia Petrisková, Dana Tahotná, Jacob Bauer, Lucia Pokorná, Roman Holič, Martin Valachovič, Vladimír Pevala, Shamshad Cockcroft, Peter Griač
Publikováno v:
FEBS letters.
Yeast Sec14-like phosphatidylinositol transfer proteins (PITPs) contain a hydrophobic cavity capable of accepting a single molecule of phosphatidylinositol (PI) or another molecule in a mutually exclusive manner. We report here that two yeast Sec14 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca26dab7bcf0c38f85199acd669ee78f
https://pubmed.ncbi.nlm.nih.gov/36482167
https://pubmed.ncbi.nlm.nih.gov/36482167
Autor:
Claire Hamilton, Antoni Olona, Stuart Leishman, Kelly MacDonald-Ramsahai, Shamshad Cockcroft, Gerald Larrouy-Maumus, Paras K. Anand
Publikováno v:
ImmunoHorizons. 6(8)
Imbalance in lipid homeostasis is associated with discrepancies in immune signaling and is tightly linked to metabolic disorders. The diverse ways in which lipids impact immune signaling, however, remain ambiguous. The phospholipid phosphatidylinosit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11facab68cf62e3d72d76a7f4d06db4c
https://pubmed.ncbi.nlm.nih.gov/36038196
https://pubmed.ncbi.nlm.nih.gov/36038196
Autor:
Shamshad Cockcroft, Matilda Katan
Publikováno v:
Essays in Biochemistry. 64:513-531
Phosphatidylinositol(4,5) bisphosphate (PI(4,5)P2) has become a major focus in biochemistry, cell biology and physiology owing to its diverse functions at the plasma membrane. As a result, the functions of PI(4,5)P2 can be explored in two separate an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6342a3866deef1a4ae750de0eef3f7
https://doi.org/10.1042/ebc20200041
https://doi.org/10.1042/ebc20200041