Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shamir, Cassim"'
Autor:
Célia Gotorbe, Jérôme Durivault, Willian Meira, Shamir Cassim, Maša Ždralević, Jacques Pouysségur, Milica Vučetić
Publikováno v:
Antioxidants, Vol 11, Iss 12, p 2412 (2022)
Glutathione peroxidase 4 (GPX4) has been reported as one of the major targets for ferroptosis induction, due to its pivotal role in lipid hydroperoxide removal. However, recent studies pointed toward alternative antioxidant systems in this context, s
Externí odkaz:
https://doaj.org/article/6fa95228102c43c2a2c2ebc446150d07
Publikováno v:
Biochemical and Biophysical Research Communications. 634:62-69
Static cold storage (SCS) is currently the most widely used method for organ preservation, but a number of limitations are associated including tissue damage and restricted opportunity for organ repair. Thus, the development of improved hypothermic s
Autor:
Christopher Montemagno, Shamir Cassim, Nicolas De Leiris, Jérôme Durivault, Marc Faraggi, Gilles Pagès
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6413 (2021)
Pancreatic ductal adenocarcinoma (PDAC), accounting for 90–95% of all pancreatic tumors, is a highly devastating disease associated with poor prognosis. The lack of accurate diagnostic tests and failure of conventional therapies contribute to this
Externí odkaz:
https://doaj.org/article/5b52c460a2a14061b706bce168eecbec
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4067 (2020)
Pancreatic ductal adenocarcinoma (PDAC), accounting for 90% of all pancreatic tumors, is a highly devastating disease with poor prognosis and rising incidence. The lack of available specific diagnostics tests and the limited treatment opportunities c
Externí odkaz:
https://doaj.org/article/ab552b104da841ed81264886f1be5886
Autor:
Laura Megrelis, Elyas El Ghoul, Federica Moalli, Margaux Versapuech, Shamir Cassim, Nora Ruef, Jens V. Stein, Marianne Mangeney, Jérôme Delon
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
We previously identified Fam65b as an atypical inhibitor of the small G protein RhoA. Using a conditional model of a Fam65b-deficient mouse, we first show that Fam65b restricts spontaneous RhoA activation in resting T lymphocytes and regulates intran
Externí odkaz:
https://doaj.org/article/8a574cb581224a63a5b7c9b17f9d3650
Autor:
Shamir Cassim, Jacques Pouyssegur
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 157 (2019)
Immune cells survey and patrol throughout the body and sometimes take residence in niche environments with distinct cellular subtypes and nutrients that may fluctuate from those in which they matured. Rooted in immune cell physiology are metabolic pa
Externí odkaz:
https://doaj.org/article/ad26b219c8204834b1c88e2f2fdaa2a0
Autor:
Tom S Chan, Shamir Cassim, Valérie-Ann Raymond, Sven Gottschalk, Grégory Merlen, Claudia Zwingmann, Pascal Lapierre, Peter Darby, Cyril David Mazer, Marc Bilodeau
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199177 (2018)
The liver is a highly vascularized organ receiving a dual input of oxygenated blood from the hepatic artery and portal vein. The impact of decreased blood flow on glucose metabolism and how hepatocytes could adapt to this restrictive environment are
Externí odkaz:
https://doaj.org/article/e5011774440a4ad6853da4fdfbd462da
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171215 (2017)
There are limited numbers of models to study hepatocellular carcinoma (HCC) in vivo in immunocompetent hosts. In an effort to develop a cell line with improved tumorigenicity, we derived a new cell line from Hepa1-6 cells through an in vivo passage i
Externí odkaz:
https://doaj.org/article/daada33d65d84f8e8ef35f353c3155ed
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190366 (2017)
The liver plays a key role in maintaining physiological homeostasis and hepatocytes are largely responsible for this. The use of isolated primary hepatocytes has become an essential tool for the study of nutrient physiology, xenobiotic metabolism and
Externí odkaz:
https://doaj.org/article/3b206f0d30684aff86af03a4ab9e0278
Autor:
Nzinga Mack, Ramesh B. Badisa, Karam F.A. Soliman, Masa Zdralevic, Shamir Cassim, Jacques Pouysségur, Elizabeth Mazzio
Publikováno v:
Cancer Genomics Proteomics
Background/aim Nearly all mammalian tumors of diverse tissues are believed to be dependent on fermentative glycolysis, marked by elevated production of lactic acid and expression of glycolytic enzymes, most notably lactic acid dehydrogenase (LDH). Th