Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shamini G Shekeran"'
Autor:
Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Repair processes in kidney are impaired in severe disease. Here, the authors show that in kidney failure, genetic or pharmacologic inhibition of IL11 releases the brake on regeneration, reverses tissue damage and restores kidney function.
Externí odkaz:
https://doaj.org/article/60e0f4d907fc4280bc1f88c1b900af64
Autor:
Benjamin Ng, Anissa A. Widjaja, Sivakumar Viswanathan, Jinrui Dong, Sonia P. Chothani, Stella Lim, Shamini G. Shekeran, Jessie Tan, Narelle E. McGregor, Emma C. Walker, Natalie A. Sims, Sebastian Schafer, Stuart A. Cook
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Loss of function (LOF) in IL11RA infers IL11 signaling as important for fertility, fibrosis, inflammation and incompletely penetrant craniosynostosis. The impact of LOF in IL11 has not been characterized. We generated IL11 knockout (Il11 −
Externí odkaz:
https://doaj.org/article/d5124096b01d4998921d03195394e3df
Autor:
Anissa A. Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G. Shekeran, David Carling, Wei-Wen Lim, Stuart A. Cook
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104806- (2022)
Summary: IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The mechanisms underlying these processes are not known. We report that IL11-stimulated ERK/P90RSK activity causes the phosphorylation of LKB1 at S325 and S428
Externí odkaz:
https://doaj.org/article/07ef08c66326440fbef0269cb7059dcd
Autor:
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K. Singh, Sonia P. Chothani, Benjamin Ng, Wei Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, Paul M. Yen, Sebastian Schafer, Stuart A. Cook, Anissa A. Widjaja
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
IL11 contributes to the development of non-alcoholic steatohepatitis (NASH) through incompletely understood mechanisms. Here, the authors report that lipotoxicity-driven autocrine IL11 activity underlies hepatocyte metabolic dysfunction and death via
Externí odkaz:
https://doaj.org/article/ce2b5ee017d5453ea86274564e8eb24f
Autor:
Anissa A. Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K. Singh, Jessie Tan, Joyce Goh Wei Ting, David Lamb, Shamini G. Shekeran, Benjamin L. George, Sebastian Schafer, David Carling, Eleonora Adami, Stuart A. Cook
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicate
Externí odkaz:
https://doaj.org/article/0cd76abbd2a44497b3b4cd44b2750de0
Autor:
Anissa A. Widjaja, Shamini G. Shekeran, Eleonora Adami, Joyce G Wei Ting, Jessie Tan, Sivakumar Viswanathan, Sze Yun Lim, Puay Hoon Tan, Norbert Hübner, Thomas Coffman, Stuart A. Cook
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Alport syndrome is a genetic disorder characterized by a defective glomerular basement membrane, tubulointerstitial fibrosis, inflammation, and progressive renal failure. IL-11 was recently implicated in fibrotic kidney disease, but its r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b1d37faad1b8bdc43960a2828a1f7b
https://doi.org/10.1681/asn.2021040577
https://doi.org/10.1681/asn.2021040577
Autor:
Anissa A. Widjaja, Joyce Goh Wei Ting, Sivakumar Viswanathan, Jessie Tan, Shamini G Shekeran, David Carling, Lim Wei Wen, Stuart A. Cook
Interleukin 11 (IL11) stimulates stromal cell activation but also causes hepatocyte metabolic dysfunction. The mechanisms underlying these seemingly unrelated processes are not known. Here we report that IL11-stimulated ERK/P90RSK activity causes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a32568bd5098cbc8b32ed90d9b39556
https://doi.org/10.1101/2022.02.10.479876
https://doi.org/10.1101/2022.02.10.479876
Autor:
Jinrui Dong, Wei-Wen Lim, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Joyce Wei Ting Goh, Benjamin L. George, Sebastian Schafer, Stuart A. Cook, Anissa A. Widjaja
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7089
N-acetyl-p-aminophenol (APAP)-induced liver damage is associated with upregulation of Interleukin-11 (IL11), which is thought to stimulate IL6ST (gp130)-mediated STAT3 activity in hepatocytes, as a compensatory response. However, recent studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172e0bc9464532f1b67971cc88b58bda
https://doi.org/10.3390/ijms23137089
https://doi.org/10.3390/ijms23137089
Autor:
Benjamin Ng, Sivakumar Viswanathan, Anissa A. Widjaja, Wei-Wen Lim, Shamini G. Shekeran, Joyce Wei Ting Goh, Jessie Tan, Fathima Kuthubudeen, Sze Yun Lim, Chen Xie, Sebastian Schafer, Eleonora Adami, Stuart A. Cook
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3549
Interleukin-11 (IL11) is important for fibrosis and inflammation, but its role in the pancreas is unclear. In pancreatitis, fibrosis, inflammation and organ dysfunction are associated with pancreatic stellate cell (PSC)-to-myofibroblast transformatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc87508ff4c95a179eaaf40c8f128ff
https://doi.org/10.3390/ijms23073549
https://doi.org/10.3390/ijms23073549
Autor:
Ng, Benjamin1,2 (AUTHOR) benjamin.ng.w.m@nhcs.com.sg, Viswanathan, Sivakumar2 (AUTHOR) anissa.widjaja@duke-nus.edu.sg, Widjaja, Anissa A.2 (AUTHOR) shamini_g@duke-nus.edu.sg, Lim, Wei-Wen1,2 (AUTHOR) jessie.tan@nhcs.com.sg, Shekeran, Shamini G.2 (AUTHOR) fathima@duke-nus.edu.sg, Goh, Joyce Wei Ting2 (AUTHOR) sy76@nus.edu.sg, Tan, Jessie1 (AUTHOR) xie.chen@nhcs.com.sg, Kuthubudeen, Fathima2 (AUTHOR) sebastian@duke-nus.edu.sg, Lim, Sze Yun2 (AUTHOR), Xie, Chen1 (AUTHOR) stuart.cook@duke-nus.edu.sg, Schafer, Sebastian2 (AUTHOR), Adami, Eleonora2,3 (AUTHOR) benjamin.ng.w.m@nhcs.com.sg, Cook, Stuart A.1,2,4 (AUTHOR)
Publikováno v:
International Journal of Molecular Sciences. Apr2022, Vol. 23 Issue 7, p3549-N.PAG. 17p.