Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sham S. Nikam"'
Autor:
Sham S. Nikam, Russell J. DeOrazio, David D. Manning, Scott Ian L, Brian Alan Sherer, Jun-Ho Maeng
Publikováno v:
Synthetic Communications. 41:3551-3555
The double metallation of 6-bromo-3H-benzothiazol-2-one and 6-bromo-3H-benzoxazol-2-one with methyl magnesium bromide and alkyllithium bases is described. Alkylation with a variety of electrophiles occurs at the 6-position of the heterocycles in good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::099db84c3064c101b0b0d8c04ab58505
https://doi.org/10.1080/00397911.2010.519093
https://doi.org/10.1080/00397911.2010.519093
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:489-493
As part of an on-going effort to investigate the chemical space requirements for D(2)/5-HT(2A) receptor antagonists as atypical antipsychotics, new 1-aminoindanes were synthesized. The replacement of the heterocycle (oxindole) in ziprasidone with a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c49d0cefb5e90a818f338bf9527c1a1
https://doi.org/10.1016/j.bmcl.2007.11.106
https://doi.org/10.1016/j.bmcl.2007.11.106
Autor:
David L. Rock, Sham S. Nikam, Joel Murray, Abdul Mutlib, Hao Chen, Lloyd Dethloff, Brian Edward Kornberg
Publikováno v:
Chemical Research in Toxicology. 19:1341-1350
Compound 1a (6-chloro-5-{3-[4-(1H-indazol-3-yl)-piperazin-1-yl]-propyl}-3,3-dimethyl-1,3-dihydro-indol-2-one) was mutagenic to Salmonella typhimurium TA98 in the presence of rat liver S9 subcellular fraction. The metabolism of 1a in rat liver S9 or m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6203031d3584ce71dd68da70343e1dcb
https://doi.org/10.1021/tx050354+
https://doi.org/10.1021/tx050354+
Autor:
Kyunghye Ahn, Semiko Kaw, Richard L Schroeder, Sharon Pan, Sarah B. Herman, Masashi Yanagisawa, Stephen J. Haleen, Donald Hupe, Noriaki Emoto, Sham S. Nikam, Xue Min Cheng, Andre M. Sisneros, Lee Chitase, Annette M. Doherty
Publikováno v:
Biochemical and Biophysical Research Communications. 243:184-190
PD 069185 is a highly selective and structurally novel inhibitor of endothelin converting enzyme-1 (ECE-1). PD 069185 is a trisubstituted quinazoline with an IC50 value of 0.9 +/- 0.1 microns for inhibition of human ECE-1 from the solubilized membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3042723ee10a540c4acc9a8ccfd3a17a
https://doi.org/10.1006/bbrc.1998.8081
https://doi.org/10.1006/bbrc.1998.8081
Autor:
Zhiping Li, Chao-Jun Li, Timothy E. Wilson, Michael P. Doyle, Maxim O. Ratnikov, Patricia D. MacLeodé, Andrew K. Jones, Sham S. Nikam
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
[75-91-2] C4H10O2 (MW 90.12) InChI = 1S/C4H10O2/c1-4(2,3)6-5/h5H,1-3H3 InChIKey = CIHOLLKRGTVIJN-UHFFFAOYSA-N (oxidizing agent used for the oxidation of alcohols and alkenes to allylic oxygenated compounds and epoxides1, 2) Alternate Name: TBHP. Phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8f32ba9a3c37e59098d642aedbaf79d
https://doi.org/10.1002/047084289x.rb385.pub3
https://doi.org/10.1002/047084289x.rb385.pub3
Autor:
Russell J. DeOrazio, Scott Ian L, David D. Manning, Jun-Ho Maeng, Brian Alan Sherer, Sham S. Nikam
Publikováno v:
ChemInform. 43
The double metallation of 6-bromo-3H-benzothiazol-2-one and 6-bromo-3H-benzoxazol-2-one with methyl magnesium bromide and alkyllithium bases is described. Alkylation with a variety of electrophiles occurs at the 6-position of the heterocycles in good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::587988e886978d5cf153f14698dffca4
https://doi.org/10.1002/chin.201216125
https://doi.org/10.1002/chin.201216125
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 9(1)
There is growing pressure to find more effective therapies for major psychiatric disorders, such as schizophrenia and depressive disorder. The repeated disappointments that have been experienced with highly selective, single-target agents have prompt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a541854e7a78dcfb8520891a6dd5071
https://pubmed.ncbi.nlm.nih.gov/18183529
https://pubmed.ncbi.nlm.nih.gov/18183529
Autor:
Sham S, Nikam, Alok K, Awasthi
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 9(1)
Many of the drugs currently marketed for the treatment of schizophrenia are dopamine D2 receptor antagonists or partial agonists with or without mixed receptor pharmacology, and primarily treat the positive symptoms of schizophrenia. These drugs, dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee4a50205c0ecfb44e440b1285435300
https://pubmed.ncbi.nlm.nih.gov/18183530
https://pubmed.ncbi.nlm.nih.gov/18183530
Autor:
Leonard T. Meltzer, Sham S. Nikam, Jon L. Wright, Julie McCormick, Kevin A. Serpa, Brian Edward Kornberg, Bridget M. Barr, Suzanne Ross Kesten, Linda L. Coughenour
Publikováno v:
ChemInform. 35
A benzylpiperidine analogue with an acetylenic linker, 5-(3-[4-(4-fluorobenzyl)-piperidin-1-yl]-prop-1-ynyl)-1,3-dihydrobenzimidazol-2-one (3), was identified as a chemical lead with excellent activity at the NR1A/2B receptor (IC50=3 nM). Efforts to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaa78f4f3421e20dd86be49c38a65b0
https://doi.org/10.1002/chin.200423162
https://doi.org/10.1002/chin.200423162
Autor:
Leonard T. Meltzer, Sham S. Nikam
Publikováno v:
Current pharmaceutical design. 8(10)
NR2B antagonists have received considerable attention in recent years. In this class of excitatory amino acid receptor antagonists NR2B antagonists have shown efficacy in neuroprotection, anti-hyperalgesic and anti-Parkinson animal models. Several gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c29d151f01f3ef69f5078e8794727b
https://pubmed.ncbi.nlm.nih.gov/11945135
https://pubmed.ncbi.nlm.nih.gov/11945135