Discovery and validation of a 3-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations; a case-control then observational cohort study

Autor: Li, HK, Kaforou, M, Rodriguez-Manzano, J, Channon-Wells, S, Monir, A, Habgood-Coote, D, Gupta, RK, Mills, EA, Lin, J, Chiu, Y-H, Pennisi, I, Miglietta, L, Mehta, R, Obaray, N, Herberg, JA, Wright, VJ, Georgiou, P, Shallcross, LJ, Mentzer, AJ, Levin, M, Cooke, GS, Noursadeghi, M, Sriskandan, S

Background: Emergency admissions for infection often lack initial diagnostic certainty. COVID-19 has highlighted a need for novel diagnostic approaches to indicate likelihood of viral infection in a pandemic setting. We sought to derive and validate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::acb005ed1452a220a1395a0910ef83fb
http://hdl.handle.net/10044/1/89138

Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study.

Autor: Li HK; Department of Infectious Disease, Imperial College London, London, UK.; Medical Research Council Centre for Molecular Bacteriology & Infection, Imperial College London, London, UK., Kaforou M; Department of Infectious Disease, Imperial College London, London, UK., Rodriguez-Manzano J; Department of Infectious Disease, Imperial College London, London, UK.; National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infection & Antimicrobial Resistance, Imperial College London, London, UK., Channon-Wells S; Department of Infectious Disease, Imperial College London, London, UK., Moniri A; Department of Electrical & Electronic Engineering, Imperial College London, London, UK., Habgood-Coote D; Department of Infectious Disease, Imperial College London, London, UK., Gupta RK; Institute of Global Health, University College London, London, UK., Mills EA; Department of Infectious Disease, Imperial College London, London, UK., Arancon D; Imperial College Healthcare NHS Trust, London, UK., Lin J; Department of Infectious Disease, Imperial College London, London, UK., Chiu YH; Department of Infectious Disease, Imperial College London, London, UK., Pennisi I; Department of Infectious Disease, Imperial College London, London, UK., Miglietta L; Department of Infectious Disease, Imperial College London, London, UK.; Department of Electrical & Electronic Engineering, Imperial College London, London, UK., Mehta R; Department of Infectious Disease, Imperial College London, London, UK., Obaray N; Department of Infectious Disease, Imperial College London, London, UK., Herberg JA; Department of Infectious Disease, Imperial College London, London, UK., Wright VJ; Department of Infectious Disease, Imperial College London, London, UK., Georgiou P; Department of Electrical & Electronic Engineering, Imperial College London, London, UK.; Centre for Bio-Inspired Technology, Imperial College London, London, UK., Shallcross LJ; Institute of Health Informatics, University College London, London, UK., Mentzer AJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Levin M; Department of Infectious Disease, Imperial College London, London, UK., Cooke GS; Department of Infectious Disease, Imperial College London, London, UK., Noursadeghi M; Division of Infection and Immunity, University College London, London, UK., Sriskandan S; Department of Infectious Disease, Imperial College London, London, UK.; Medical Research Council Centre for Molecular Bacteriology & Infection, Imperial College London, London, UK.; National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infection & Antimicrobial Resistance, Imperial College London, London, UK.

Publikováno v: The Lancet. Microbe [Lancet Microbe] 2021 Nov; Vol. 2 (11), pp. e594-e603. Date of Electronic Publication: 2021 Aug 16.

Antibiotic prescribing in UK care homes 2016-2017: retrospective cohort study of linked data.

Autor: Smith CM; Institute of Health Informatics, University College London, London, NW1 2DA, UK. catherine.m.smith@ucl.ac.uk., Williams H; Four Seasons Health Care, Norcliffe House, Station Road, Wilmslow, Cheshire, SK9 1BU, UK., Jhass A; Institute of Health Informatics, University College London, London, NW1 2DA, UK.; Research Department of Primary Care and Population Health, University College London, London, NW3 2PF, UK., Patel S; Institute of Health Informatics, University College London, London, NW1 2DA, UK., Crayton E; Centre for Behaviour Change, University College London, WC1E 7HB, London, UK., Lorencatto F; Centre for Behaviour Change, University College London, WC1E 7HB, London, UK., Michie S; Centre for Behaviour Change, University College London, WC1E 7HB, London, UK., Hayward AC; Institute of Epidemiology and Health Care, University College London, WC1E 7HB, London, UK., Shallcross LJ; Institute of Health Informatics, University College London, London, NW1 2DA, UK.

Publikováno v: BMC health services research [BMC Health Serv Res] 2020 Jun 18; Vol. 20 (1), pp. 555. Date of Electronic Publication: 2020 Jun 18.

Nosocomial transmission of influenza: A retrospective cross-sectional study using next generation sequencing at a hospital in England (2012-2014).

Autor: Blackburn RM; Institute of Health Informatics, UCL, London, UK., Frampton D; Division of Infection and Immunity, UCL, London, UK., Smith CM; Institute of Health Informatics, UCL, London, UK., Fragaszy EB; Institute of Health Informatics, UCL, London, UK.; Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Watson SJ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Ferns RB; Clinical Microbiology and Virology, University College London Hospitals NHS Foundation Trust, London, UK., Binter Š; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Coen PG; Infection Control Department, University College London Hospitals, NHS Foundation Trust, London, UK., Grant P; Clinical Microbiology and Virology, University College London Hospitals NHS Foundation Trust, London, UK., Shallcross LJ; Institute of Health Informatics, UCL, London, UK., Kozlakidis Z; Institute of Health Informatics, UCL, London, UK.; International Agency for Research on Cancer, World Health Organization, Lyon, France., Pillay D; Division of Infection and Immunity, UCL, London, UK.; Africa Health Research Institute, Durban, South Africa., Kellam P; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Hué S; Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Nastouli E; Clinical Microbiology and Virology, University College London Hospitals NHS Foundation Trust, London, UK.; Department of Population, Policy and Practice, UCL Institute of Child Health, London, UK., Hayward AC; Institute of Epidemiology and Health Care, UCL, London, UK.

Publikováno v: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2019 Nov; Vol. 13 (6), pp. 556-563. Date of Electronic Publication: 2019 Sep 19.

Cohort study protocol: Bioresource in Adult Infectious Diseases (BioAID).

Autor: Shallcross LJ; Institute of Health Informatics, University College London, London, NW1 2DA, UK., Mentzer A; Wellcome Trust Centre for Human Genetics and the Jenner Institute, University of Oxford, Oxford, UK., Rahman S; Biomedical Research Centre, Great Ormond Street Hospital for Children, London, WC1N 1EH, UK., Cooke GS; Department of Medicine, Imperial College London, London, SW7 2AZ, UK., Sriskandan S; Department of Medicine, Imperial College London, London, SW7 2AZ, UK.; NIHR Health Protection Unit in Antimicrobial Resistance and Healthcare Acquired Infection, Imperial College London, London, UK., Noursadeghi M; Division of Infection and Immunity, UCL, London, UK.; National Insitute of Health Research Biomedical Research Centre, UCLH/UCL, London, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2018 Aug 08; Vol. 3, pp. 97. Date of Electronic Publication: 2018 Aug 08 (Print Publication: 2018).