FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer

Autor: Yang Wu, Zheqi Li, Abdalla M. Wedn, Allison N. Casey, Daniel Brown, Shalini V. Rao, Soleilmane Omarjee, Jagmohan Hooda, Jason S. Carroll, Jason Gertz, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich

Publikováno v: Molecular Cancer Research. 21:591-604

Estrogen receptor alpha (ER/ESR1) mutations occur in 30% to 40% of endocrine resistant ER-positive (ER+) breast cancer. Forkhead box A1 (FOXA1) is a key pioneer factor mediating ER–chromatin interactions and endocrine response in ER+ breast cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0cff9df5d95de9fa51424b9e24af71c
https://doi.org/10.1158/1541-7786.mcr-22-0516

Supplementary Figures 1-8 from FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer

Autor: Steffi Oesterreich, Adrian V. Lee, Jennifer M. Atkinson, Jason Gertz, Jason S. Carroll, Jagmohan Hooda, Soleilmane Omarjee, Shalini V. Rao, Daniel Brown, Allison N. Casey, Abdalla M. Wedn, Zheqi Li, Yang Wu

S1. FOXA1 redistribution in ESR1 mutant cells causes distinct ER-FOXA1 interaction.S2. FOXA1 gained peaks annotated genes are significantly associated with novel target genes.S3. FOXA1 redistribution in ESR1 mutant cells confers potential RXR binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c12d03baf664d3111b46bf66e4ed650
https://doi.org/10.1158/1541-7786.22593319.v1

The tumour microenvironment shapes the epigenetic landscape of PDAC

Autor: Catarina Pelicano, Joshua Kent, Valar Franklin, Kamal Kishore, Giulia Biffi, Igor Chernukhin, Shalini V. Rao, Jason S. Carroll

Publikováno v: Pancreatology. 23:e9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a1899b483bbff07bf6c815aedb73295
https://doi.org/10.1016/j.pan.2023.04.028

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Autor: Cara Brodie, Danya Cheeseman, Dominique-Laurent Couturier, Sanjeev Kumar, Jason S. Carroll, Naomi Guppy, Kosuke Yusa, Evangelia K. Papachristou, Sankari Nagarajan, Jose-Enrique Gonzalez Prada, Carlos Caldas, Alejandra Bruna, Joseph Sutton, Shanade Dunn, Emily Archer Goode, Silvia-Elena Glont, Rachael Natrajan, Shalini V. Rao, Igor Chernukhin, Rasmus Siersbæk, Kamal Kishore, Chandra Sekhar Reddy Chilamakuri, Alasdair Russell

Publikováno v: Nature Genetics
Nature genetics
Nagarajan, S, Rao, S V, Sutton, J, Cheeseman, D, Dunn, S, Papachristou, E K, Prada, J G, Couturier, D, Kumar, S, Kishore, K, Chilamakuri, C S R, Glont, S, Archer Goode, E, Brodie, C, Guppy, N, Natrajan, R, Bruna, A, Caldas, C, Russell, A, Siersbæk, R, Yusa, K, Chernukhin, I & Carroll, J S 2020, ' ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response ', Nature Genetics, vol. 52, no. 2, pp. 187-197 . https://doi.org/10.1038/s41588-019-0541-5

Using genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screens to understand endocrine drug resistance, we discovered ARID1A and other SWI/SNF complex components as the factors most critically required for response to tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8541d5c793f7939ad7f665331d15a4fc
https://pubmed.ncbi.nlm.nih.gov/32005967

Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Autor: Dominique-Laurent Couturier, Jose-Enrique Gonzalez Prada, Rachael Natrajan, Carlos Caldas, Rasmus Siersbæk, Kamal Kishore, Shalini V. Rao, Igor Chernukhin, Cara Brodie, Jason S. Carroll, Silvia-Elena Glont, Alejandra Bruna, Chandra Sekhar Reddy Chilamakuri, Emily Archer Goode, Evangelia K. Papachristou, Alasdair Russell, Sankari Nagarajan, Danya Cheeseman, Naomi Guppy, Sanjeev Kumar, Kosuke Yusa, Joseph Sutton, Shanade Dunn

Publikováno v: Nature Genetics. 52:354-354

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0133977e4753e716a560b216800ec67d
https://doi.org/10.1038/s41588-020-0582-9